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The mechanism of action of vagus nerve stimulation for refractory epilepsy: the current status

Kristl Vonck UGent, Koen Van Laere, Stefanie Dedeurwaerdere, Jacques Caemaert UGent, Jacques De Reuck UGent and Paul Boon UGent (2001) JOURNAL OF CLINICAL NEUROPHYSIOLOGY. 18(5). p.394-401
abstract
Vagus nerve stimulation (VNS) is a neurophysiologic treatment for patients with medically or surgically refractory epilepsy. Since the first human implant in 1989, more than 10,000 patients have been treated with VNS. The precise mechanism of action remains to be elucidated. Animal experiments with VNS were initially performed to demonstrate efficacy and safety preceding the clinical trials in human patients. Mechanism of action research involving animal experiments can provide essential clues. Animal experiments are often labor-intensive even in the hands of experienced researchers, however, and the results remain only a reflection of the complicated pathophysiologic systems of the human brain. Mechanism of action research in human patients treated with VNS is particularly challenging because of safety concerns, the large number of patients required, and the heterogenous nature of various small patient series. This study provides an overview of the progress that has been made in the past 10 years through neurophysiologic, neuroanatomic, neurochemical, and cerebral blood flow studies in animals and patients treated with VNS. Further elucidation of the mechanism of action of VNS may increase its clinical efficacy. It may also provide inspiration for the development of new therapeutic modalities for refractory epilepsy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
mechanism of action, vagus nerve stimulation, refractory epilepsy, BLOOD-FLOW, VAGAL-STIMULATION, SEIZURES, HUMANS, THERAPY, BRAIN, INHIBITION
journal title
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
J. Clin. Neurophysiol.
volume
18
issue
5
pages
394 - 401
Web of Science type
Review
Web of Science id
000172564400002
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.538 (2001)
JCR rank
26/135 (2001)
JCR quartile
1 (2001)
ISSN
0736-0258
DOI
10.1097/00004691-200109000-00002
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
142089
handle
http://hdl.handle.net/1854/LU-142089
date created
2004-01-14 13:37:00
date last changed
2012-05-22 13:37:32
@article{142089,
  abstract     = {Vagus nerve stimulation (VNS) is a neurophysiologic treatment for patients with medically or surgically refractory epilepsy. Since the first human implant in 1989, more than 10,000 patients have been treated with VNS. The precise mechanism of action remains to be elucidated. Animal experiments with VNS were initially performed to demonstrate efficacy and safety preceding the clinical trials in human patients. Mechanism of action research involving animal experiments can provide essential clues. Animal experiments are often labor-intensive even in the hands of experienced researchers, however, and the results remain only a reflection of the complicated pathophysiologic systems of the human brain. Mechanism of action research in human patients treated with VNS is particularly challenging because of safety concerns, the large number of patients required, and the heterogenous nature of various small patient series. This study provides an overview of the progress that has been made in the past 10 years through neurophysiologic, neuroanatomic, neurochemical, and cerebral blood flow studies in animals and patients treated with VNS. Further elucidation of the mechanism of action of VNS may increase its clinical efficacy. It may also provide inspiration for the development of new therapeutic modalities for refractory epilepsy.},
  author       = {Vonck, Kristl and Van Laere, Koen and Dedeurwaerdere, Stefanie and Caemaert, Jacques and De Reuck, Jacques and Boon, Paul},
  issn         = {0736-0258},
  journal      = {JOURNAL OF CLINICAL NEUROPHYSIOLOGY},
  keyword      = {mechanism of action,vagus nerve stimulation,refractory epilepsy,BLOOD-FLOW,VAGAL-STIMULATION,SEIZURES,HUMANS,THERAPY,BRAIN,INHIBITION},
  language     = {eng},
  number       = {5},
  pages        = {394--401},
  title        = {The mechanism of action of vagus nerve stimulation for refractory epilepsy: the current status},
  url          = {http://dx.doi.org/10.1097/00004691-200109000-00002},
  volume       = {18},
  year         = {2001},
}

Chicago
Vonck, Kristl, Koen Van Laere, Stefanie Dedeurwaerdere, Jacques Caemaert, Jacques De Reuck, and Paul Boon. 2001. “The Mechanism of Action of Vagus Nerve Stimulation for Refractory Epilepsy: The Current Status.” Journal of Clinical Neurophysiology 18 (5): 394–401.
APA
Vonck, K., Van Laere, K., Dedeurwaerdere, S., Caemaert, J., De Reuck, J., & Boon, P. (2001). The mechanism of action of vagus nerve stimulation for refractory epilepsy: the current status. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 18(5), 394–401.
Vancouver
1.
Vonck K, Van Laere K, Dedeurwaerdere S, Caemaert J, De Reuck J, Boon P. The mechanism of action of vagus nerve stimulation for refractory epilepsy: the current status. JOURNAL OF CLINICAL NEUROPHYSIOLOGY. 2001;18(5):394–401.
MLA
Vonck, Kristl, Koen Van Laere, Stefanie Dedeurwaerdere, et al. “The Mechanism of Action of Vagus Nerve Stimulation for Refractory Epilepsy: The Current Status.” JOURNAL OF CLINICAL NEUROPHYSIOLOGY 18.5 (2001): 394–401. Print.