Ghent University Academic Bibliography

Advanced

Programmed and magnet-induced vagus nerve stimulation for refractory epilepsy

Paul Boon UGent, Kristl Vonck UGent, Phyllis Van Walleghem, Michel D'Havé, LUTGARD GOOSSENS UGent, Tom Vandekerckhove UGent, Jacques Caemaert UGent and Jacques De Reuck UGent (2001) JOURNAL OF CLINICAL NEUROPHYSIOLOGY. 18(5). p.402-407
abstract
Vagus nerve stimulation (VNS) is an effective alternative treatment for patients with refractory epilepsy. The generator produces intermittent stimulation trains and does not require patient intervention. Using currently available technology, continuous stimulation is incompatible with a reasonable battery life. Because earlier studies have demonstrated the persistence of a stimulation effect after discontinuation of the stimulation train, we intended to evaluate the clinical efficacy of VNS in both the programmed intermittent stimulation mode and the magnet stimulation mode. Patients, companions, and caregivers were instructed on how to administer additional stimulation trains when an aura or a seizure onset occurred. We assumed that patients or caregivers could recognize habitual seizures and were able to evaluate sudden interruption of these seizures. During a mean follow-up of 35 months, 46% of patients became responders, with a reduction in seizure frequency of more than 50%. Twenty-nine percent of patients stopped having convulsive seizures. In two thirds of patients who were able to self-administer or receive additional magnet stimulation, seizures could be interrupted consistently or occasionally. More than half of the patients who reported a positive effect of magnet stimulation became responders. Only three patients were able to use the magnet themselves. In most cases, support from caregivers was necessary. This study is the first to document the efficacy of magnet-induced VNS in a larger patient population during long-term follow-up. The magnet is a useful tool that provides patients who are treated with VNS and mainly caregivers of such patients with an additional means of controlling seizures. To further confirm the self-reported results from our patients, additional studies comparing programmed stimulation and magnet-induced stimulation during monitoring conditions are needed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
epilepsy, magnet-induced stimulation, vagus nerve stimulation, EFFICACY, SAFETY, TRIAL, PARTIAL SEIZURES
journal title
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
J. Clin. Neurophysiol.
volume
18
issue
5
pages
402 - 407
Web of Science type
Review
Web of Science id
000172564400003
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.538 (2001)
JCR rank
26/135 (2001)
JCR quartile
1 (2001)
ISSN
0736-0258
DOI
10.1097/00004691-200109000-00003
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
142000
handle
http://hdl.handle.net/1854/LU-142000
date created
2004-01-14 13:37:00
date last changed
2012-05-22 14:00:33
@article{142000,
  abstract     = {Vagus nerve stimulation (VNS) is an effective alternative treatment for patients with refractory epilepsy. The generator produces intermittent stimulation trains and does not require patient intervention. Using currently available technology, continuous stimulation is incompatible with a reasonable battery life. Because earlier studies have demonstrated the persistence of a stimulation effect after discontinuation of the stimulation train, we intended to evaluate the clinical efficacy of VNS in both the programmed intermittent stimulation mode and the magnet stimulation mode. Patients, companions, and caregivers were instructed on how to administer additional stimulation trains when an aura or a seizure onset occurred. We assumed that patients or caregivers could recognize habitual seizures and were able to evaluate sudden interruption of these seizures. During a mean follow-up of 35 months, 46\% of patients became responders, with a reduction in seizure frequency of more than 50\%. Twenty-nine percent of patients stopped having convulsive seizures. In two thirds of patients who were able to self-administer or receive additional magnet stimulation, seizures could be interrupted consistently or occasionally. More than half of the patients who reported a positive effect of magnet stimulation became responders. Only three patients were able to use the magnet themselves. In most cases, support from caregivers was necessary. This study is the first to document the efficacy of magnet-induced VNS in a larger patient population during long-term follow-up. The magnet is a useful tool that provides patients who are treated with VNS and mainly caregivers of such patients with an additional means of controlling seizures. To further confirm the self-reported results from our patients, additional studies comparing programmed stimulation and magnet-induced stimulation during monitoring conditions are needed.},
  author       = {Boon, Paul and Vonck, Kristl and Van Walleghem, Phyllis and D'Hav{\'e}, Michel and GOOSSENS, LUTGARD and Vandekerckhove, Tom and Caemaert, Jacques and De Reuck, Jacques},
  issn         = {0736-0258},
  journal      = {JOURNAL OF CLINICAL NEUROPHYSIOLOGY},
  keyword      = {epilepsy,magnet-induced stimulation,vagus nerve stimulation,EFFICACY,SAFETY,TRIAL,PARTIAL SEIZURES},
  language     = {eng},
  number       = {5},
  pages        = {402--407},
  title        = {Programmed and magnet-induced vagus nerve stimulation for refractory epilepsy},
  url          = {http://dx.doi.org/10.1097/00004691-200109000-00003},
  volume       = {18},
  year         = {2001},
}

Chicago
Boon, Paul, Kristl Vonck, Phyllis Van Walleghem, Michel D’Havé, LUTGARD GOOSSENS, Tom Vandekerckhove, Jacques Caemaert, and Jacques De Reuck. 2001. “Programmed and Magnet-induced Vagus Nerve Stimulation for Refractory Epilepsy.” Journal of Clinical Neurophysiology 18 (5): 402–407.
APA
Boon, P., Vonck, K., Van Walleghem, P., D’Havé, M., GOOSSENS, L., Vandekerckhove, T., Caemaert, J., et al. (2001). Programmed and magnet-induced vagus nerve stimulation for refractory epilepsy. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 18(5), 402–407.
Vancouver
1.
Boon P, Vonck K, Van Walleghem P, D’Havé M, GOOSSENS L, Vandekerckhove T, et al. Programmed and magnet-induced vagus nerve stimulation for refractory epilepsy. JOURNAL OF CLINICAL NEUROPHYSIOLOGY. 2001;18(5):402–7.
MLA
Boon, Paul, Kristl Vonck, Phyllis Van Walleghem, et al. “Programmed and Magnet-induced Vagus Nerve Stimulation for Refractory Epilepsy.” JOURNAL OF CLINICAL NEUROPHYSIOLOGY 18.5 (2001): 402–407. Print.