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Correlation between maternal and infant HIV infection and low birth weight: a study in Mombasa, Kenya

F. Mwanyumba, Patricia Claeys, P. Gaillard, Chris Verhofstede UGent, V. Chohan, Kishor Mandaliya, J. Ndinya-Achola, J. Bwayo and Marleen Temmerman UGent (2001) JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 21(1). p.27-31
abstract
This article aimed to examine the association between maternal and infant HIV infection and low birth weight (LBW <2500 grams). Datafrom 8563 singleton liveborns in Mombasa, Kenya, were analysed. Maternal HIV infection was found in 14·1% of the women and 9·6% of neonates had a birth weight of <2500 grams. In multivariate analysis, maternal HIV infection was independently associated with LBW (RR=1·46, 95% CI=1·20-1·79, P =0·0002). Maternal age, primiparity, sex of the baby, religion, syphilis infection, anaemia and previous history of stillbirth were also independently associated with LBW (RR: 1·32, 2·19, 1·44, 1·56, 1·61, 1·31 and 1·69, respectively). The rate of intra-uterine HIV transmission was 5·1% and 20·1% of the exposed infants were infected during the intrapartum period. Intrapartum infected infants had a relative risk of LBW of 1·95 (95% CI=1·18-2·87, P <0·01) compared to uninfected children, whereas the birth weight of infants infected in utero was not different from uninfected infants (RR=1·18, 95% CI=0·56-2·60, P=0·630). HIV infected mothers are more likely to have small babies, even after controlling for possible confounding factors. Low birth weight babies were more at risk for peripartum HIV transmission, but further research is needed to study mechanisms of transmission in relation to birth weight.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
J. Obstet. Gynaecol.
volume
21
issue
1
pages
27-31 pages
ISSN
0144-3615
DOI
10.1080/01443610020022078
language
English
UGent publication?
yes
classification
A2
id
141501
handle
http://hdl.handle.net/1854/LU-141501
date created
2004-01-14 13:37:00
date last changed
2016-12-19 15:38:06
@article{141501,
  abstract     = {This article aimed to examine the association between maternal and infant HIV infection and low birth weight (LBW {\textlangle}2500 grams). Datafrom 8563 singleton liveborns in Mombasa, Kenya, were analysed. Maternal HIV infection was found in 14{\textperiodcentered}1\% of the women and 9{\textperiodcentered}6\% of neonates had a birth weight of {\textlangle}2500 grams. In multivariate analysis, maternal HIV infection was independently associated with LBW (RR=1{\textperiodcentered}46, 95\% CI=1{\textperiodcentered}20-1{\textperiodcentered}79, P =0{\textperiodcentered}0002). Maternal age, primiparity, sex of the baby, religion, syphilis infection, anaemia and previous history of stillbirth were also independently associated with LBW (RR: 1{\textperiodcentered}32, 2{\textperiodcentered}19, 1{\textperiodcentered}44, 1{\textperiodcentered}56, 1{\textperiodcentered}61, 1{\textperiodcentered}31 and 1{\textperiodcentered}69, respectively). The rate of intra-uterine HIV transmission was 5{\textperiodcentered}1\% and 20{\textperiodcentered}1\% of the exposed infants were infected during the intrapartum period. Intrapartum infected infants had a relative risk of LBW of 1{\textperiodcentered}95 (95\% CI=1{\textperiodcentered}18-2{\textperiodcentered}87, P {\textlangle}0{\textperiodcentered}01) compared to uninfected children, whereas the birth weight of infants infected in utero was not different from uninfected infants (RR=1{\textperiodcentered}18, 95\% CI=0{\textperiodcentered}56-2{\textperiodcentered}60, P=0{\textperiodcentered}630). HIV infected mothers are more likely to have small babies, even after controlling for possible confounding factors. Low birth weight babies were more at risk for peripartum HIV transmission, but further research is needed to study mechanisms of transmission in relation to birth weight.},
  author       = {Mwanyumba, F. and Claeys, Patricia and Gaillard, P. and Verhofstede, Chris and Chohan, V. and Mandaliya, Kishor and Ndinya-Achola, J. and Bwayo, J. and Temmerman, Marleen},
  issn         = {0144-3615},
  journal      = {JOURNAL OF OBSTETRICS AND GYNAECOLOGY},
  language     = {eng},
  number       = {1},
  pages        = {27--31},
  title        = {Correlation between maternal and infant HIV infection and low birth weight: a study in Mombasa, Kenya},
  url          = {http://dx.doi.org/10.1080/01443610020022078},
  volume       = {21},
  year         = {2001},
}

Chicago
Mwanyumba, F., Patricia Claeys, P. Gaillard, Chris Verhofstede, V. Chohan, Kishor Mandaliya, J. Ndinya-Achola, J. Bwayo, and Marleen Temmerman. 2001. “Correlation Between Maternal and Infant HIV Infection and Low Birth Weight: a Study in Mombasa, Kenya.” Journal of Obstetrics and Gynaecology 21 (1): 27–31.
APA
Mwanyumba, F., Claeys, P., Gaillard, P., Verhofstede, C., Chohan, V., Mandaliya, K., Ndinya-Achola, J., et al. (2001). Correlation between maternal and infant HIV infection and low birth weight: a study in Mombasa, Kenya. JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 21(1), 27–31.
Vancouver
1.
Mwanyumba F, Claeys P, Gaillard P, Verhofstede C, Chohan V, Mandaliya K, et al. Correlation between maternal and infant HIV infection and low birth weight: a study in Mombasa, Kenya. JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 2001;21(1):27–31.
MLA
Mwanyumba, F., Patricia Claeys, P. Gaillard, et al. “Correlation Between Maternal and Infant HIV Infection and Low Birth Weight: a Study in Mombasa, Kenya.” JOURNAL OF OBSTETRICS AND GYNAECOLOGY 21.1 (2001): 27–31. Print.