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Serum α-tocopherol and selenium in Belgian infants and children

Stephanie Van Biervliet UGent, Jean-Pierre Van Biervliet, Dirk Bernard, Marc Matthys, Raf Vercaemst and Vic Blaton (2001) BIOLOGICAL TRACE ELEMENT RESEARCH. 79(2). p.115-120
abstract
Previous studies showed low selenium (Se) concentrations in Belgian children. Serum a-tocopherol, retinol, total cholesterol, high-density lipoprotein and low-density lipoprotein cholesterol, selenium (Se), and thiobarbituric acid-reactive substances were examined. In order to obtain further information on the Se status in Belgian children, Se, cx-tocopherol, retinol, and lipid concentrations were examined and signs of peroxidative Lipid damage were evaluated in a subgroup. The study was performed in 524 children (0-14 yr old) during vaccination campaigns. Three age groups were analyzed: 0-1, 1-4, and 4-14 yr. In 87 of them, where sufficient amounts of serum were available, analysis of thiobarbituric acid-reactive substances was done. Infants have high serum a-tocopherol concentrations: (23.2 mu mol/L [median and interquartile range: 18.6-30.2]) and low Se concentrations (0.37 mol/L [0.27-0.47]). Se concentrations rise significantly during the first 4 yr (p < 0.0001) (Mann-Whitney U-test, tied p-values): 0.70 <mu>mol/L (0.59-0.82); in the 4-14 yr olds, it was 0.75 mu mol/L (0.67-0.86). These values remain low compared to results coming from other parts of the world. a-Tocopherol concentrations decrease significantly after infancy (p < 0.0001). The ratio <alpha>-tocopherol/total cholesterol is higher in infants. This is induced by the high vitamin E content of infant formulas. Signs of serum lipid peroxidation could not be detected by analysis of serum malondialdehyde concentrations. High alpha -tocopherol concentrations, as those observed in infant serum lipids, could be one of the protective mechanisms from the peroxidative lipid damages, sometimes observed in a low-Se status.
Please use this url to cite or link to this publication:
author
organization
alternative title
Serum alpha-tocopherol and selenium in Belgian infants and children
year
type
journalArticle (original)
publication status
published
subject
keyword
PLASMA, ACID, DENSITY-LIPOPROTEIN, VITAMIN-E, retinol, malonyldialdehyde, selenium, cholesterol, alpha-tocopherol, child
journal title
BIOLOGICAL TRACE ELEMENT RESEARCH
Biol. Trace Elem. Res.
volume
79
issue
2
pages
115 - 120
Web of Science type
Article
Web of Science id
000168154900003
JCR category
NUTRITION & DIETETICS
JCR impact factor
0.769 (2001)
JCR rank
32/49 (2001)
JCR quartile
3 (2001)
ISSN
0163-4984
DOI
10.1385/BTER:79:2:115
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
141183
handle
http://hdl.handle.net/1854/LU-141183
date created
2004-01-14 13:37:00
date last changed
2016-12-19 15:38:04
@article{141183,
  abstract     = {Previous studies showed low selenium (Se) concentrations in Belgian children. Serum a-tocopherol, retinol, total cholesterol, high-density lipoprotein and low-density lipoprotein cholesterol, selenium (Se), and thiobarbituric acid-reactive substances were examined. In order to obtain further information on the Se status in Belgian children, Se, cx-tocopherol, retinol, and lipid concentrations were examined and signs of peroxidative Lipid damage were evaluated in a subgroup. 
The study was performed in 524 children (0-14 yr old) during vaccination campaigns. Three age groups were analyzed: 0-1, 1-4, and 4-14 yr. In 87 of them, where sufficient amounts of serum were available, analysis of thiobarbituric acid-reactive substances was done. Infants have high serum a-tocopherol concentrations: (23.2 mu mol/L [median and interquartile range: 18.6-30.2]) and low Se concentrations (0.37 mol/L [0.27-0.47]). Se concentrations rise significantly during the first 4 yr (p {\textlangle} 0.0001) (Mann-Whitney U-test, tied p-values): 0.70 {\textlangle}mu{\textrangle}mol/L (0.59-0.82); in the 4-14 yr olds, it was 0.75 mu mol/L (0.67-0.86). These values remain low compared to results coming from other parts of the world. a-Tocopherol concentrations decrease significantly after infancy (p {\textlangle} 0.0001). The ratio {\textlangle}alpha{\textrangle}-tocopherol/total cholesterol is higher in infants. This is induced by the high vitamin E content of infant formulas. Signs of serum lipid peroxidation could not be detected by analysis of serum malondialdehyde concentrations. 
High alpha -tocopherol concentrations, as those observed in infant serum lipids, could be one of the protective mechanisms from the peroxidative lipid damages, sometimes observed in a low-Se status.},
  author       = {Van Biervliet, Stephanie and Van Biervliet, Jean-Pierre and Bernard, Dirk and Matthys, Marc and Vercaemst, Raf and Blaton, Vic},
  issn         = {0163-4984},
  journal      = {BIOLOGICAL TRACE ELEMENT RESEARCH},
  keyword      = {PLASMA,ACID,DENSITY-LIPOPROTEIN,VITAMIN-E,retinol,malonyldialdehyde,selenium,cholesterol,alpha-tocopherol,child},
  language     = {eng},
  number       = {2},
  pages        = {115--120},
  title        = {Serum \ensuremath{\alpha}-tocopherol and selenium in Belgian infants and children},
  url          = {http://dx.doi.org/10.1385/BTER:79:2:115},
  volume       = {79},
  year         = {2001},
}

Chicago
Van Biervliet, Stephanie, Jean-Pierre Van Biervliet, Dirk Bernard, Marc Matthys, Raf Vercaemst, and Vic Blaton. 2001. “Serum Α-tocopherol and Selenium in Belgian Infants and Children.” Biological Trace Element Research 79 (2): 115–120.
APA
Van Biervliet, Stephanie, Van Biervliet, J.-P., Bernard, D., Matthys, M., Vercaemst, R., & Blaton, V. (2001). Serum α-tocopherol and selenium in Belgian infants and children. BIOLOGICAL TRACE ELEMENT RESEARCH, 79(2), 115–120.
Vancouver
1.
Van Biervliet S, Van Biervliet J-P, Bernard D, Matthys M, Vercaemst R, Blaton V. Serum α-tocopherol and selenium in Belgian infants and children. BIOLOGICAL TRACE ELEMENT RESEARCH. 2001;79(2):115–20.
MLA
Van Biervliet, Stephanie, Jean-Pierre Van Biervliet, Dirk Bernard, et al. “Serum Α-tocopherol and Selenium in Belgian Infants and Children.” BIOLOGICAL TRACE ELEMENT RESEARCH 79.2 (2001): 115–120. Print.