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Distribution of substitution rates and location of insertion sites in the tertiary structure of ribosomal RNA

Jan Wuyts UGent, Yves Van de Peer UGent and Rupert De Wachter (2001) NUCLEIC ACIDS RESEARCH. 29(24). p.5017-5028
abstract
The relative substitution rate of each nucleotide site in bacterial small subunit rRNA, large subunit rRNA and 5S rRNA was calculated from sequence alignments for each molecule. Two-dimensional and three-dimensional variability maps of the rRNAs were obtained by plotting the substitution rates on secondary structure models and on the tertiary structure of the rRNAs available from X-ray diffraction results. This showed that the substitution rates are generally low near the centre of the ribosome, where the nucleotides essential for its function are situated, and that they increase towards the surface. An inventory was made of insertions characteristic of the Archaea, Bacteria and Eucarya domains, and for additional insertions present in specific eukaryotic taxa. All these insertions occur at the ribosome surface. The taxon-specific insertions seem to arise randomly in the eukaryotic evolutionary tree, without any phylogenetic relatedness between the taxa possessing them.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DATABASE, EVOLUTION, RECONSTRUCTION, MITOCHONDRIA, SEQUENCES, PHYLOGENY, GIARDIA-LAMBLIA, SECONDARY STRUCTURE, SUBUNIT RNA, ANGSTROM RESOLUTION
journal title
NUCLEIC ACIDS RESEARCH
Nucleic Acids Res.
volume
29
issue
24
pages
5017 - 5028
Web of Science type
Article
Web of Science id
000172871800015
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
6.373 (2001)
JCR rank
36/304 (2001)
JCR quartile
1 (2001)
ISSN
0305-1048
DOI
10.1093/nar/29.24.5017
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
138845
handle
http://hdl.handle.net/1854/LU-138845
date created
2004-01-14 13:37:00
date last changed
2017-05-05 11:18:59
@article{138845,
  abstract     = {The relative substitution rate of each nucleotide site in bacterial small subunit rRNA, large subunit rRNA and 5S rRNA was calculated from sequence alignments for each molecule. Two-dimensional and three-dimensional variability maps of the rRNAs were obtained by plotting the substitution rates on secondary structure models and on the tertiary structure of the rRNAs available from X-ray diffraction results. This showed that the substitution rates are generally low near the centre of the ribosome, where the nucleotides essential for its function are situated, and that they increase towards the surface. An inventory was made of insertions characteristic of the Archaea, Bacteria and Eucarya domains, and for additional insertions present in specific eukaryotic taxa. All these insertions occur at the ribosome surface. The taxon-specific insertions seem to arise randomly in the eukaryotic evolutionary tree, without any phylogenetic relatedness between the taxa possessing them.},
  author       = {Wuyts, Jan and Van de Peer, Yves and De Wachter, Rupert},
  issn         = {0305-1048},
  journal      = {NUCLEIC ACIDS RESEARCH},
  keyword      = {DATABASE,EVOLUTION,RECONSTRUCTION,MITOCHONDRIA,SEQUENCES,PHYLOGENY,GIARDIA-LAMBLIA,SECONDARY STRUCTURE,SUBUNIT RNA,ANGSTROM RESOLUTION},
  language     = {eng},
  number       = {24},
  pages        = {5017--5028},
  title        = {Distribution of substitution rates and location of insertion sites in the tertiary structure of ribosomal RNA},
  url          = {http://dx.doi.org/10.1093/nar/29.24.5017},
  volume       = {29},
  year         = {2001},
}

Chicago
Wuyts, Jan, Yves Van de Peer, and Rupert De Wachter. 2001. “Distribution of Substitution Rates and Location of Insertion Sites in the Tertiary Structure of Ribosomal RNA.” Nucleic Acids Research 29 (24): 5017–5028.
APA
Wuyts, Jan, Van de Peer, Y., & De Wachter, R. (2001). Distribution of substitution rates and location of insertion sites in the tertiary structure of ribosomal RNA. NUCLEIC ACIDS RESEARCH, 29(24), 5017–5028.
Vancouver
1.
Wuyts J, Van de Peer Y, De Wachter R. Distribution of substitution rates and location of insertion sites in the tertiary structure of ribosomal RNA. NUCLEIC ACIDS RESEARCH. 2001;29(24):5017–28.
MLA
Wuyts, Jan, Yves Van de Peer, and Rupert De Wachter. “Distribution of Substitution Rates and Location of Insertion Sites in the Tertiary Structure of Ribosomal RNA.” NUCLEIC ACIDS RESEARCH 29.24 (2001): 5017–5028. Print.