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The att locus of Rhodococcus fascians strain D188 is essential for full virulence on tobacco through the production of an autoregulatory compound

Tania Maes UGent, Danny Vereecke UGent, Tita Ritsema, Karen Cornelis, Hang Ngo Thi Thu, Marc Van Montagu UGent, Marcella Holsters UGent and Koen Goethals UGent (2001) MOLECULAR MICROBIOLOGY. 42(1). p.13-28
abstract
The ability of Rhodococcus fascians strain D188 to provoke leafy gall formation on a variety of plant species is correlated with the linear plasmid pFiD188, on which different pathogenicity loci were identified. The att locus affects the severity of symptom development on tobacco, whereas the fas locus is essential for virulence. To gain insight into the function of the att locus, sequence and expression analyses were performed. The att locus contains nine open reading frames homologous to arginine and beta -lactam biosynthetic genes. aft gene expression is transcriptionally induced by leafy gall extracts, but not by extracts of uninfected plants, and depends on the attR gene that encodes a LysR-type transcriptional regulator. The att locus proves to be essential for the formation of inducing factors (IFs) that are present in gall extracts. Because the induction of the las locus also requires the presence of IFs in gall extracts, the att locus is proposed to play an important role in regulating the expression of the virulence loci of R. fascians.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ESCHERICHIA-COLI, TRANSCRIPTIONAL REGULATORS, BETA-LACTAM, LUXR-LUXI FAMILY, CLAVULANIC ACID BIOSYNTHESIS, GRAM-POSITIVE BACTERIA, STREPTOMYCES-CLAVULIGERUS, NUCLEOTIDE-SEQUENCE, LEAFY GALL, GENE
journal title
MOLECULAR MICROBIOLOGY
Mol. Microbiol.
volume
42
issue
1
pages
13 - 28
Web of Science type
Article
Web of Science id
000171585500003
JCR category
MICROBIOLOGY
JCR impact factor
6.398 (2001)
JCR rank
7/81 (2001)
JCR quartile
1 (2001)
ISSN
0950-382X
DOI
10.1046/j.1365-2958.2001.02615.x
language
English
UGent publication?
yes
classification
A1
additional info
The first two authors contributed equally to this work.
copyright statement
I have transferred the copyright for this publication to the publisher
id
138681
handle
http://hdl.handle.net/1854/LU-138681
date created
2004-01-14 13:37:00
date last changed
2014-04-07 13:34:43
@article{138681,
  abstract     = {The ability of Rhodococcus fascians strain D188 to provoke leafy gall formation on a variety of plant species is correlated with the linear plasmid pFiD188, on which different pathogenicity loci were identified. The att locus affects the severity of symptom development on tobacco, whereas the fas locus is essential for virulence. To gain insight into the function of the att locus, sequence and expression analyses were performed. The att locus contains nine open reading frames homologous to arginine and beta -lactam biosynthetic genes. aft gene expression is transcriptionally induced by leafy gall extracts, but not by extracts of uninfected plants, and depends on the attR gene that encodes a LysR-type transcriptional regulator. The att locus proves to be essential for the formation of inducing factors (IFs) that are present in gall extracts. Because the induction of the las locus also requires the presence of IFs in gall extracts, the att locus is proposed to play an important role in regulating the expression of the virulence loci of R. fascians.},
  author       = {Maes, Tania and Vereecke, Danny and Ritsema, Tita and Cornelis, Karen and Thu, Hang Ngo Thi and Van Montagu, Marc and Holsters, Marcella and Goethals, Koen},
  issn         = {0950-382X},
  journal      = {MOLECULAR MICROBIOLOGY},
  keyword      = {ESCHERICHIA-COLI,TRANSCRIPTIONAL REGULATORS,BETA-LACTAM,LUXR-LUXI FAMILY,CLAVULANIC ACID BIOSYNTHESIS,GRAM-POSITIVE BACTERIA,STREPTOMYCES-CLAVULIGERUS,NUCLEOTIDE-SEQUENCE,LEAFY GALL,GENE},
  language     = {eng},
  number       = {1},
  pages        = {13--28},
  title        = {The att locus of Rhodococcus fascians strain D188 is essential for full virulence on tobacco through the production of an autoregulatory compound},
  url          = {http://dx.doi.org/10.1046/j.1365-2958.2001.02615.x},
  volume       = {42},
  year         = {2001},
}

Chicago
Maes, Tania, Danny Vereecke, Tita Ritsema, Karen Cornelis, Hang Ngo Thi Thu, Marc Van Montagu, Marcella Holsters, and Koen Goethals. 2001. “The Att Locus of Rhodococcus Fascians Strain D188 Is Essential for Full Virulence on Tobacco Through the Production of an Autoregulatory Compound.” Molecular Microbiology 42 (1): 13–28.
APA
Maes, Tania, Vereecke, D., Ritsema, T., Cornelis, K., Thu, H. N. T., Van Montagu, M., Holsters, M., et al. (2001). The att locus of Rhodococcus fascians strain D188 is essential for full virulence on tobacco through the production of an autoregulatory compound. MOLECULAR MICROBIOLOGY, 42(1), 13–28.
Vancouver
1.
Maes T, Vereecke D, Ritsema T, Cornelis K, Thu HNT, Van Montagu M, et al. The att locus of Rhodococcus fascians strain D188 is essential for full virulence on tobacco through the production of an autoregulatory compound. MOLECULAR MICROBIOLOGY. 2001;42(1):13–28.
MLA
Maes, Tania, Danny Vereecke, Tita Ritsema, et al. “The Att Locus of Rhodococcus Fascians Strain D188 Is Essential for Full Virulence on Tobacco Through the Production of an Autoregulatory Compound.” MOLECULAR MICROBIOLOGY 42.1 (2001): 13–28. Print.