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CKS1At overexpression in Arabidopsis thaliana inhibits growth by reducing meristem size and inhibiting cell-cycle progression

Lieven De Veylder (UGent) , Gerrit Beemster (UGent) , Tom Beeckman (UGent) and Dirk Inzé (UGent)
(2001) PLANT JOURNAL. 25(6). p.617-626
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Abstract
The SUC1/CKS1 proteins associate with cyclin-dependent kinases (CDKs) and play an essential role in the regulation of the cell cycle. Recently, an Arabidopsis thaliana SUC1/CKS1 homologous gene, designated CKS1At, has been cloned. Here, overexpression of CKS1At in Arabidopsis is shown to reduce leaf size and root growth rates. Reduced root growth resulted primarily from an increase of the cell-cycle duration and a shortening of the meristem. Endoreduplication was unaffected. The increased cell-cycle duration was associated with an equal extension of both the G1 and G2 phases. This inhibition was due to the binding of CDK subunits with CDKs. The reduced growth rates in response to altered cell-cycle gene expression demonstrates a direct dependence of plant growth rates on cell-cycle regulation.
Keywords
CDK, Arabidopsis thaliana, cell cycle, CKS1At, kinematic analysis, root growth, XENOPUS SUC1/CKS PROTEIN, CRYSTAL-STRUCTURE, FISSION YEAST, ROOT-GROWTH, SCHIZOSACCHAROMYCES-POMBE, LEAF ELONGATION, KINASE COMPLEX, DIVISION, GENE, CDC2

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Chicago
De Veylder, Lieven, Gerrit Beemster, Tom Beeckman, and Dirk Inzé. 2001. “CKS1At Overexpression in Arabidopsis Thaliana Inhibits Growth by Reducing Meristem Size and Inhibiting Cell-cycle Progression.” Plant Journal 25 (6): 617–626.
APA
De Veylder, L., Beemster, G., Beeckman, T., & Inzé, D. (2001). CKS1At overexpression in Arabidopsis thaliana inhibits growth by reducing meristem size and inhibiting cell-cycle progression. PLANT JOURNAL, 25(6), 617–626.
Vancouver
1.
De Veylder L, Beemster G, Beeckman T, Inzé D. CKS1At overexpression in Arabidopsis thaliana inhibits growth by reducing meristem size and inhibiting cell-cycle progression. PLANT JOURNAL. 2001;25(6):617–26.
MLA
De Veylder, Lieven, Gerrit Beemster, Tom Beeckman, et al. “CKS1At Overexpression in Arabidopsis Thaliana Inhibits Growth by Reducing Meristem Size and Inhibiting Cell-cycle Progression.” PLANT JOURNAL 25.6 (2001): 617–626. Print.
@article{138633,
  abstract     = {The SUC1/CKS1 proteins associate with cyclin-dependent kinases (CDKs) and play an essential role in the regulation of the cell cycle. Recently, an Arabidopsis thaliana SUC1/CKS1 homologous gene, designated CKS1At, has been cloned. Here, overexpression of CKS1At in Arabidopsis is shown to reduce leaf size and root growth rates. Reduced root growth resulted primarily from an increase of the cell-cycle duration and a shortening of the meristem. Endoreduplication was unaffected. The increased cell-cycle duration was associated with an equal extension of both the G1 and G2 phases. This inhibition was due to the binding of CDK subunits with CDKs. The reduced growth rates in response to altered cell-cycle gene expression demonstrates a direct dependence of plant growth rates on cell-cycle regulation.},
  author       = {De Veylder, Lieven and Beemster, Gerrit and Beeckman, Tom and Inzé, Dirk},
  issn         = {0960-7412},
  journal      = {PLANT JOURNAL},
  keywords     = {CDK,Arabidopsis thaliana,cell cycle,CKS1At,kinematic analysis,root growth,XENOPUS SUC1/CKS PROTEIN,CRYSTAL-STRUCTURE,FISSION YEAST,ROOT-GROWTH,SCHIZOSACCHAROMYCES-POMBE,LEAF ELONGATION,KINASE COMPLEX,DIVISION,GENE,CDC2},
  language     = {eng},
  number       = {6},
  pages        = {617--626},
  title        = {CKS1At overexpression in Arabidopsis thaliana inhibits growth by reducing meristem size and inhibiting cell-cycle progression},
  url          = {http://dx.doi.org/10.1046/j.1365-313x.2001.00996.x},
  volume       = {25},
  year         = {2001},
}

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