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Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis

Lieven De Veylder UGent, Tom Beeckman UGent, Gerrit Beemster UGent, Luc Krols, Franky Terras, Isabelle Landrieu, Els Van Der Schueren, Sara Maes UGent, Mirande Naudts UGent and Dirk Inzé UGent (2001) PLANT CELL. 13(7). p.1653-1667
abstract
Cyclin-dependent kinase inhibitors, such as the mammalian p27(Kip1) protein, regulate correct cell cycle progression and the integration of developmental signals with the core cell cycle machinery. These inhibitors have been described in plants, but their function remains unresolved. We have isolated seven genes from Arabidopsis that encode proteins with distant sequence homology with p27(Kip1), designated Kip-related proteins (KRPs). The KRPs were characterized by their domain organization and transcript profiles, With the exception of KRP5, all presented the same cyclin-dependent kinase binding specificity. When overproduced, KRP2 dramatically inhibited cell cycle progression in leaf primordia cells without affecting the temporal pattern of cell division and differentiation. Mature transgenic leaves were serrated and consisted of enlarged cells. Although the ploidy levels in young leaves were unaffected, endoreduplication was suppressed in older leaves. We conclude that KRP2 exerts a plant growth inhibitory activity by reducing cell proliferation in leaves, but, in contrast to its mammalian counterparts, it may not control the timing of cell cycle exit and differentiation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EXPRESSION, P27(KIP1), PLANTS, PROTEIN, THALIANA, ROOT-GROWTH, CDK INHIBITORS, MEDIATED TRANSFORMATION, CELL-CYCLE, FISSION YEAST
journal title
PLANT CELL
Plant Cell
volume
13
issue
7
pages
1653 - 1667
Web of Science type
Article
Web of Science id
000170061400013
JCR category
PLANT SCIENCES
JCR impact factor
11.081 (2001)
JCR rank
2/134 (2001)
JCR quartile
1 (2001)
ISSN
1040-4651
DOI
10.1105/tpc.13.7.1653
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
138629
handle
http://hdl.handle.net/1854/LU-138629
date created
2004-01-14 13:37:00
date last changed
2016-12-19 15:37:50
@article{138629,
  abstract     = {Cyclin-dependent kinase inhibitors, such as the mammalian p27(Kip1) protein, regulate correct cell cycle progression and the integration of developmental signals with the core cell cycle machinery. These inhibitors have been described in plants, but their function remains unresolved. We have isolated seven genes from Arabidopsis that encode proteins with distant sequence homology with p27(Kip1), designated Kip-related proteins (KRPs). The KRPs were characterized by their domain organization and transcript profiles, With the exception of KRP5, all presented the same cyclin-dependent kinase binding specificity. When overproduced, KRP2 dramatically inhibited cell cycle progression in leaf primordia cells without affecting the temporal pattern of cell division and differentiation. Mature transgenic leaves were serrated and consisted of enlarged cells. Although the ploidy levels in young leaves were unaffected, endoreduplication was suppressed in older leaves. We conclude that KRP2 exerts a plant growth inhibitory activity by reducing cell proliferation in leaves, but, in contrast to its mammalian counterparts, it may not control the timing of cell cycle exit and differentiation.},
  author       = {De Veylder, Lieven and Beeckman, Tom and Beemster, Gerrit and Krols, Luc and Terras, Franky and Landrieu, Isabelle and Van Der Schueren, Els and Maes, Sara and Naudts, Mirande and Inz{\'e}, Dirk},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {EXPRESSION,P27(KIP1),PLANTS,PROTEIN,THALIANA,ROOT-GROWTH,CDK INHIBITORS,MEDIATED TRANSFORMATION,CELL-CYCLE,FISSION YEAST},
  language     = {eng},
  number       = {7},
  pages        = {1653--1667},
  title        = {Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis},
  url          = {http://dx.doi.org/10.1105/tpc.13.7.1653},
  volume       = {13},
  year         = {2001},
}

Chicago
De Veylder, Lieven, Tom Beeckman, Gerrit Beemster, Luc Krols, Franky Terras, Isabelle Landrieu, ELS VAN DER SCHUEREN, Sara Maes, Mirande Naudts, and Dirk Inzé. 2001. “Functional Analysis of Cyclin-dependent Kinase Inhibitors of Arabidopsis.” Plant Cell 13 (7): 1653–1667.
APA
De Veylder, L., Beeckman, T., Beemster, G., Krols, L., Terras, F., Landrieu, I., VAN DER SCHUEREN, E., et al. (2001). Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis. PLANT CELL, 13(7), 1653–1667.
Vancouver
1.
De Veylder L, Beeckman T, Beemster G, Krols L, Terras F, Landrieu I, et al. Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis. PLANT CELL. 2001;13(7):1653–67.
MLA
De Veylder, Lieven, Tom Beeckman, Gerrit Beemster, et al. “Functional Analysis of Cyclin-dependent Kinase Inhibitors of Arabidopsis.” PLANT CELL 13.7 (2001): 1653–1667. Print.