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Treatment of acute Escherichia coli mastitis in cows with enrofloxacin: effect on clinical signs and chemiluminescence of circulating neutrophils.

Dagmar Hoeben, Erica Monfardini, Christian Burvenich UGent and J Hamann (2000) JOURNAL OF DAIRY RESEARCH. 67(4). p.485-502
abstract
We have studied the effect of treatment with enrofloxacin on local and general clinical signs and chemiluminescence of circulating polymorphonuclear leucocytes during experimentally induced Escherichia coli mastitis in cows immediately after parturition. Twelve cows were infected with 10(4) cfu Esch. coli P4:O32 into both left quarters. Six cows received an intravenous injection of 5 mg enrofloxacin/kg at 10 h after infection and a second enrofloxacin treatment administered subcutaneously at 30 h post infection. The other six cows were controls that received no treatment. General clinical signs (fever, tachycardia, loss of appetite, reduced rumen motility and depression) were similar in both groups. Local clinical signs, such as swelling, pain and firmness of the inflamed mammary quarters, were less severe in the treated cows. We saw no difference in the appearance of the milk: fleck and watery or purulent milk were observed in both groups. The beneficial effects of treatment with enrofloxacin were mainly on milk production and composition. The decline in milk production and the changes in milk concentrations of lactose, Na+ and bovine serum albumin were less pronounced in the treated cows. Treatment with enrofloxacin accelerated the clearance of bacteria from the infected quarters, but had no effect on the chemiluminescence response of isolated polymorphonuclear leucocytes. The changes in the number of circulating leucocytes and the appearance of immature neutrophils in the circulation of the treated cows indicated possible beneficial effects on migration of neutrophils into the inflamed glands. Higher milk somatic cell counts in the treated cows supported this hypothesis. The results of this study indicated that treating cows that have been experimentally infected with Esch. coli mastitis after parturition with enrofloxacin reduced the severity of the disease, especially the decline in milk production and the changes in milk composition.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DAIRY-COWS, BLOOD POLYMORPHONUCLEAR LEUKOCYTES, RESPIRATORY BURST, PERIOD
journal title
JOURNAL OF DAIRY RESEARCH
J. Dairy Res.
volume
67
issue
4
pages
485-502 pages
Web of Science type
Article
Web of Science id
000165977100003
ISSN
0022-0299
language
English
UGent publication?
yes
classification
A1
additional info
FT N/A
id
131476
handle
http://hdl.handle.net/1854/LU-131476
date created
2004-01-14 13:36:00
date last changed
2016-12-19 15:38:03
@article{131476,
  abstract     = {We have studied the effect of treatment with enrofloxacin on local and general clinical signs and chemiluminescence of circulating polymorphonuclear leucocytes during experimentally induced Escherichia coli mastitis in cows immediately after parturition. Twelve cows were infected with 10(4) cfu Esch. coli P4:O32 into both left quarters. Six cows received an intravenous injection of 5 mg enrofloxacin/kg at 10 h after infection and a second enrofloxacin treatment administered subcutaneously at 30 h post infection. The other six cows were controls that received no treatment. General clinical signs (fever, tachycardia, loss of appetite, reduced rumen motility and depression) were similar in both groups. Local clinical signs, such as swelling, pain and firmness of the inflamed mammary quarters, were less severe in the treated cows. We saw no difference in the appearance of the milk: fleck and watery or purulent milk were observed in both groups. The beneficial effects of treatment with enrofloxacin were mainly on milk production and composition. The decline in milk production and the changes in milk concentrations of lactose, Na+ and bovine serum albumin were less pronounced in the treated cows. Treatment with enrofloxacin accelerated the clearance of bacteria from the infected quarters, but had no effect on the chemiluminescence response of isolated polymorphonuclear leucocytes. The changes in the number of circulating leucocytes and the appearance of immature neutrophils in the circulation of the treated cows indicated possible beneficial effects on migration of neutrophils into the inflamed glands. Higher milk somatic cell counts in the treated cows supported this hypothesis. The results of this study indicated that treating cows that have been experimentally infected with Esch. coli mastitis after parturition with enrofloxacin reduced the severity of the disease, especially the decline in milk production and the changes in milk composition.},
  author       = {Hoeben, Dagmar and Monfardini, Erica and Burvenich, Christian and Hamann, J},
  issn         = {0022-0299},
  journal      = {JOURNAL OF DAIRY RESEARCH},
  keyword      = {DAIRY-COWS,BLOOD POLYMORPHONUCLEAR LEUKOCYTES,RESPIRATORY BURST,PERIOD},
  language     = {eng},
  number       = {4},
  pages        = {485--502},
  title        = {Treatment of acute Escherichia coli mastitis in cows with enrofloxacin: effect on clinical signs and chemiluminescence of circulating neutrophils.},
  volume       = {67},
  year         = {2000},
}

Chicago
Hoeben, Dagmar, Erica Monfardini, Christian Burvenich, and J Hamann. 2000. “Treatment of Acute Escherichia Coli Mastitis in Cows with Enrofloxacin: Effect on Clinical Signs and Chemiluminescence of Circulating Neutrophils.” Journal of Dairy Research 67 (4): 485–502.
APA
Hoeben, Dagmar, Monfardini, E., Burvenich, C., & Hamann, J. (2000). Treatment of acute Escherichia coli mastitis in cows with enrofloxacin: effect on clinical signs and chemiluminescence of circulating neutrophils. JOURNAL OF DAIRY RESEARCH, 67(4), 485–502.
Vancouver
1.
Hoeben D, Monfardini E, Burvenich C, Hamann J. Treatment of acute Escherichia coli mastitis in cows with enrofloxacin: effect on clinical signs and chemiluminescence of circulating neutrophils. JOURNAL OF DAIRY RESEARCH. 2000;67(4):485–502.
MLA
Hoeben, Dagmar, Erica Monfardini, Christian Burvenich, et al. “Treatment of Acute Escherichia Coli Mastitis in Cows with Enrofloxacin: Effect on Clinical Signs and Chemiluminescence of Circulating Neutrophils.” JOURNAL OF DAIRY RESEARCH 67.4 (2000): 485–502. Print.