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Ethnic differences in arterial wave reflections and normative equations for augmentation index

Julio Chirinos Medina UGent, Jan Kips UGent, Mary J Roman, Josefina Medina-Lezama, Yan Li, Angela J Woodiwiss, Gavin R Norton, Yasmin Yasmin, Lucas Van Bortel, Ji-Guang Wang, et al. (2011) HYPERTENSION. 57(6). p.1108-U153
abstract
Data regarding ethnic differences in wave reflections, which markedly affect the central pressure profile, are very limited. Furthermore, because age, heart rate, and body height are strong determinants of augmentation index, relating single measurements to normative data (in which augmentation index values correspond with average population values of its determinants) is challenging. We studied subject-level data from 10 550 adults enrolled in large population-based studies. In a healthy reference sample (n = 3497), we assessed ethnic differences in augmentation index (ratio of second/first systolic peaks) and generated equations for adjusted z scores, allowing for a standardized comparison between individual augmentation index measurements and the normative population mean from subjects of the same age, sex, ethnic population, body height, and heart rate. After adjustment for age, body height, heart rate, and mean arterial pressure, African blacks (women: 154%; men: 138%) and Andean Hispanics (women: 152%; men: 133%) demonstrated higher central (aortic) augmentation index values than British whites (women: 140%; men: 128%), whereas American Indians (women: 133%; men: 122%) demonstrated lower augmentation index (all P < 0.0001), without significant differences between Chinese and British whites. Similar results were found for radial augmentation index. Nonlinear ethnic/sex-specific equations for z scores were successfully generated to adjust individual augmentation index values for age, body height, and heart rate. Marked ethnic differences in augmentation index exist, which may contribute to ethnic differences in hypertensive organ damage. Our study provides normative data that can be used to complement the interpretation of individual hemodynamic assessments among men and women of various ethnic populations, after removing the effect of various physiological determinants. (Hypertension. 2011;57:1108-1116.). Online Data Supplement
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MEN, HEMODYNAMICS, STIFFNESS, POPULATION, VASCULAR-DISEASE, PULSE-WAVE, BLOOD-PRESSURE, LEFT-VENTRICULAR HYPERTROPHY, REFERENCE VALUES, CARDIOVASCULAR-DISEASE, wave reflections, augmentation index, ethnicity
journal title
HYPERTENSION
Hypertension
volume
57
issue
6
pages
1108 - U153
Web of Science type
Article
Web of Science id
000290710800023
JCR category
PERIPHERAL VASCULAR DISEASE
JCR impact factor
6.207 (2011)
JCR rank
4/67 (2011)
JCR quartile
1 (2011)
ISSN
0194-911X
DOI
10.1161/HYPERTENSIONAHA.110.166348
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1314195
handle
http://hdl.handle.net/1854/LU-1314195
date created
2011-06-22 12:18:29
date last changed
2016-12-19 15:44:49
@article{1314195,
  abstract     = {Data regarding ethnic differences in wave reflections, which markedly affect the central pressure profile, are very limited. Furthermore, because age, heart rate, and body height are strong determinants of augmentation index, relating single measurements to normative data (in which augmentation index values correspond with average population values of its determinants) is challenging. We studied subject-level data from 10 550 adults enrolled in large population-based studies. In a healthy reference sample (n = 3497), we assessed ethnic differences in augmentation index (ratio of second/first systolic peaks) and generated equations for adjusted z scores, allowing for a standardized comparison between individual augmentation index measurements and the normative population mean from subjects of the same age, sex, ethnic population, body height, and heart rate. After adjustment for age, body height, heart rate, and mean arterial pressure, African blacks (women: 154\%; men: 138\%) and Andean Hispanics (women: 152\%; men: 133\%) demonstrated higher central (aortic) augmentation index values than British whites (women: 140\%; men: 128\%), whereas American Indians (women: 133\%; men: 122\%) demonstrated lower augmentation index (all P {\textlangle} 0.0001), without significant differences between Chinese and British whites. Similar results were found for radial augmentation index. Nonlinear ethnic/sex-specific equations for z scores were successfully generated to adjust individual augmentation index values for age, body height, and heart rate. Marked ethnic differences in augmentation index exist, which may contribute to ethnic differences in hypertensive organ damage. Our study provides normative data that can be used to complement the interpretation of individual hemodynamic assessments among men and women of various ethnic populations, after removing the effect of various physiological determinants. (Hypertension. 2011;57:1108-1116.). Online Data Supplement},
  author       = {Chirinos Medina, Julio and Kips, Jan and Roman, Mary J and Medina-Lezama, Josefina and Li, Yan and Woodiwiss, Angela J and Norton, Gavin R and Yasmin, Yasmin and Van Bortel, Lucas and Wang, Ji-Guang and Cockcroft, John R and Devereux, Richard B and Wilkinson, Ian B and Segers, Patrick and McEniery, Carmel M},
  issn         = {0194-911X},
  journal      = {HYPERTENSION},
  keyword      = {MEN,HEMODYNAMICS,STIFFNESS,POPULATION,VASCULAR-DISEASE,PULSE-WAVE,BLOOD-PRESSURE,LEFT-VENTRICULAR HYPERTROPHY,REFERENCE VALUES,CARDIOVASCULAR-DISEASE,wave reflections,augmentation index,ethnicity},
  language     = {eng},
  number       = {6},
  pages        = {1108--U153},
  title        = {Ethnic differences in arterial wave reflections and normative equations for augmentation index},
  url          = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.166348},
  volume       = {57},
  year         = {2011},
}

Chicago
Chirinos Medina, Julio, Jan Kips, Mary J Roman, Josefina Medina-Lezama, Yan Li, Angela J Woodiwiss, Gavin R Norton, et al. 2011. “Ethnic Differences in Arterial Wave Reflections and Normative Equations for Augmentation Index.” Hypertension 57 (6): 1108–U153.
APA
Chirinos Medina, J., Kips, J., Roman, M. J., Medina-Lezama, J., Li, Y., Woodiwiss, A. J., Norton, G. R., et al. (2011). Ethnic differences in arterial wave reflections and normative equations for augmentation index. HYPERTENSION, 57(6), 1108–U153.
Vancouver
1.
Chirinos Medina J, Kips J, Roman MJ, Medina-Lezama J, Li Y, Woodiwiss AJ, et al. Ethnic differences in arterial wave reflections and normative equations for augmentation index. HYPERTENSION. 2011;57(6):1108–U153.
MLA
Chirinos Medina, Julio, Jan Kips, Mary J Roman, et al. “Ethnic Differences in Arterial Wave Reflections and Normative Equations for Augmentation Index.” HYPERTENSION 57.6 (2011): 1108–U153. Print.