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The influence of sufentanil and/or clonidine on the duration of analgesia after a caudal block for hypospadias repair surgery in children

JC De Mey, J Strobbe, Jan Poelaert UGent, Piet Hoebeke UGent and Eric Mortier UGent (2000) EUROPEAN JOURNAL OF ANAESTHESIOLOGY. 17(6). p.379-382
abstract
The aim of this study was to evaluate whether the addition of clonidine, or sufentanil, or both, to a bupivacaine solution for a caudal block prolonged the period of analgesia after operation in children. Sixty ASA class I or II boys, aged between 8 months and 13 years, admitted for hypospadias repair were enrolled into a prospective randomised study. After induction of general anaesthesia and endotracheal intubation the children were allocated into four groups. Group I received 0.5 mL kg(-1) bupivacaine 0.25% caudally, in addition group II received 1 mu g kg(-1) clonidine, group III 0.5 mu g kg(-1) sufentanil and group IV 0.5 mu g kg(-1) clonidine and 0.25 mu g kg(-1) sufentanil. The concentrations of clonidine and sufentanil in group IV were halved to reduce possible side-effects with higher dosages. Analgesia acid side-effects were assessed 2, 4, 6, 8 and 12 h after operation. No significant differences were found among the four groups for the pain scores at 2, 4, 6, 8 and 12 h. All groups had a similar frequency of vomiting and a comparable appetite and quality of night rest during the first 24 h following the operation. There was no significant difference in the requirement for additional doses of analgesics. The addition of sufentanil, or clonidine, or both, to bupivacaine for caudal administration provides no additional clinical benefit over bupivacaine alone.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
anaesthesia, caudal, epidural, clonidine, analgesics, adrenergic alpha-agonists, adrenergic antagonists, sufentanil, opioid, MIXTURE, MORPHINE, ANESTHESIA, ADRENALINE, FENTANYL, POSTOPERATIVE ANALGESIA, BUPIVACAINE, anaesthetics, local, bupivacaine, specialities, medical, paediatrics
journal title
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Eur. J. Anaesth.
volume
17
issue
6
pages
379 - 382
Web of Science type
Article
Web of Science id
000088167100013
ISSN
0265-0215
DOI
10.1046/j.1365-2346.2000.00690.x
language
English
UGent publication?
yes
classification
A1
id
127164
handle
http://hdl.handle.net/1854/LU-127164
date created
2004-01-14 13:36:00
date last changed
2017-03-09 13:13:07
@article{127164,
  abstract     = {The aim of this study was to evaluate whether the addition of clonidine, or sufentanil, or both, to a bupivacaine solution for a caudal block prolonged the period of analgesia after operation in children. Sixty ASA class I or II boys, aged between 8 months and 13 years, admitted for hypospadias repair were enrolled into a prospective randomised study. After induction of general anaesthesia and endotracheal intubation the children were allocated into four groups. Group I received 0.5 mL kg(-1) bupivacaine 0.25\% caudally, in addition group II received 1 mu g kg(-1) clonidine, group III 0.5 mu g kg(-1) sufentanil and group IV 0.5 mu g kg(-1) clonidine and 0.25 mu g kg(-1) sufentanil. The concentrations of clonidine and sufentanil in group IV were halved to reduce possible side-effects with higher dosages. Analgesia acid side-effects were assessed 2, 4, 6, 8 and 12 h after operation. No significant differences were found among the four groups for the pain scores at 2, 4, 6, 8 and 12 h. All groups had a similar frequency of vomiting and a comparable appetite and quality of night rest during the first 24 h following the operation. There was no significant difference in the requirement for additional doses of analgesics. The addition of sufentanil, or clonidine, or both, to bupivacaine for caudal administration provides no additional clinical benefit over bupivacaine alone.},
  author       = {De Mey, JC and Strobbe, J and Poelaert, Jan and Hoebeke, Piet and Mortier, Eric},
  issn         = {0265-0215},
  journal      = {EUROPEAN JOURNAL OF ANAESTHESIOLOGY},
  keyword      = {anaesthesia,caudal,epidural,clonidine,analgesics,adrenergic alpha-agonists,adrenergic antagonists,sufentanil,opioid,MIXTURE,MORPHINE,ANESTHESIA,ADRENALINE,FENTANYL,POSTOPERATIVE ANALGESIA,BUPIVACAINE,anaesthetics,local,bupivacaine,specialities,medical,paediatrics},
  language     = {eng},
  number       = {6},
  pages        = {379--382},
  title        = {The influence of sufentanil and/or clonidine on the duration of analgesia after a caudal block for hypospadias repair surgery in children},
  url          = {http://dx.doi.org/10.1046/j.1365-2346.2000.00690.x},
  volume       = {17},
  year         = {2000},
}

Chicago
De Mey, JC, J Strobbe, Jan Poelaert, Piet Hoebeke, and Eric Mortier. 2000. “The Influence of Sufentanil And/or Clonidine on the Duration of Analgesia After a Caudal Block for Hypospadias Repair Surgery in Children.” European Journal of Anaesthesiology 17 (6): 379–382.
APA
De Mey, JC, Strobbe, J., Poelaert, J., Hoebeke, P., & Mortier, E. (2000). The influence of sufentanil and/or clonidine on the duration of analgesia after a caudal block for hypospadias repair surgery in children. EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 17(6), 379–382.
Vancouver
1.
De Mey J, Strobbe J, Poelaert J, Hoebeke P, Mortier E. The influence of sufentanil and/or clonidine on the duration of analgesia after a caudal block for hypospadias repair surgery in children. EUROPEAN JOURNAL OF ANAESTHESIOLOGY. 2000;17(6):379–82.
MLA
De Mey, JC, J Strobbe, Jan Poelaert, et al. “The Influence of Sufentanil And/or Clonidine on the Duration of Analgesia After a Caudal Block for Hypospadias Repair Surgery in Children.” EUROPEAN JOURNAL OF ANAESTHESIOLOGY 17.6 (2000): 379–382. Print.