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Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis)

Tim Bouts, Polly Taylor, Karla Berry, Andrew Routh and Frank Gasthuys UGent (2011) VETERINARY ANAESTHESIA AND ANALGESIA. 38(2). p.106-112
abstract
Objective To investigate physiological and sedative/ immobilization effects of medetomidine or dexmedetomidine combined with ketamine in free-ranging Chinese water deer (CWD). Study design Prospective clinical trial. Animals 10 free-ranging adult Chinese water deer (11.0 +/- 2.6 kg). Methods Animals were darted intramuscularly with 0.08 +/- 0.004 mg kg(-1) medetomidine and 3.2 +/- 0.2 mg kg(-1) ketamine (MK) or 0.04 +/- 0.01 mg kg(-1) dexmedetomidine and 2.9 +/- 0.1 mg kg(-1) ketamine (DMK) If the animal was still laterally recumbent after 60 minutes of immobilization, atipamezole was administered intravenously (MK: 0.4 +/- 0.02 mg kg(-1), DMK: 0.2 +/- 0.03 mg kg(-1)). Heart rate (HR) respiratory rate (f(R)) and temperature were recorded at 5-minute intervals. Arterial blood was taken 15 and 45 minutes after initial injection. Statistical analysis was performed using Student's t-test or ANOVA. p < 0.05 was considered significant. Results Animals became recumbent rapidly in both groups. Most had involuntary ear twitches, but there was no response to external stimuli. There were no statistical differences in mean HR (MK: 75 +/- 14 beats minute(-1); DMK: 85 +/- 21 beats minute(-1)), f(R) (MK: 51 +/- 35 breaths minute(-1); DMK; 36 +/- 9 breaths minute(-1)), temperature (MK: 38.1 +/- 0.7 degrees C; DMK: 38.4 +/- 0.5 degrees C), blood gas values (MK: PaO2 63 +/- 6 mmHg, PaCO2 49.6 +/- 2.6 mmHg, HCO3- 30.8 +/- 4.5 mmol L-1; DMK: PaO2 77 +/- 35 mmHg, PaCO2 45.9 +/- 11.5 mmHg, HCO3- 31.0 +/- 4.5 mmol L-1) and biochemical values between groups but temperature decreased in both groups. All animals needed antagonism of immobilization after 60 minutes. Recovery was quick and uneventful. There were no adverse effects after recovery. Conclusion and clinical relevance Both anaesthetic protocols provided satisfactory immobilisation. There was no clear preference for either protocol and both appear suitable for CWD.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
dexmedetomidine, deer, ketamine, medetomidine, atipamezole
journal title
VETERINARY ANAESTHESIA AND ANALGESIA
Vet. Anaesth. Analg.
volume
38
issue
2
pages
106 - 112
Web of Science type
Article
Web of Science id
000287152300005
JCR category
VETERINARY SCIENCES
JCR impact factor
0.944 (2011)
JCR rank
58/141 (2011)
JCR quartile
2 (2011)
ISSN
1467-2987
DOI
10.1111/j.1467-2995.2010.00591.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1267422
handle
http://hdl.handle.net/1854/LU-1267422
date created
2011-06-17 14:40:51
date last changed
2011-06-17 16:09:12
@article{1267422,
  abstract     = {Objective To investigate physiological and sedative/ immobilization effects of medetomidine or dexmedetomidine combined with ketamine in free-ranging Chinese water deer (CWD).
Study design Prospective clinical trial.
Animals 10 free-ranging adult Chinese water deer (11.0 +/- 2.6 kg).
Methods Animals were darted intramuscularly with 0.08 +/- 0.004 mg kg(-1) medetomidine and 3.2 +/- 0.2 mg kg(-1) ketamine (MK) or 0.04 +/- 0.01 mg kg(-1) dexmedetomidine and 2.9 +/- 0.1 mg kg(-1) ketamine (DMK) If the animal was still laterally recumbent after 60 minutes of immobilization, atipamezole was administered intravenously (MK: 0.4 +/- 0.02 mg kg(-1), DMK: 0.2 +/- 0.03 mg kg(-1)). Heart rate (HR) respiratory rate (f(R)) and temperature were recorded at 5-minute intervals. Arterial blood was taken 15 and 45 minutes after initial injection. Statistical analysis was performed using Student's t-test or ANOVA. p {\textlangle} 0.05 was considered significant.
Results Animals became recumbent rapidly in both groups. Most had involuntary ear twitches, but there was no response to external stimuli. There were no statistical differences in mean HR (MK: 75 +/- 14 beats minute(-1); DMK: 85 +/- 21 beats minute(-1)), f(R) (MK: 51 +/- 35 breaths minute(-1); DMK; 36 +/- 9 breaths minute(-1)), temperature (MK: 38.1 +/- 0.7 degrees C; DMK: 38.4 +/- 0.5 degrees C), blood gas values (MK: PaO2 63 +/- 6 mmHg, PaCO2 49.6 +/- 2.6 mmHg, HCO3- 30.8 +/- 4.5 mmol L-1; DMK: PaO2 77 +/- 35 mmHg, PaCO2 45.9 +/- 11.5 mmHg, HCO3- 31.0 +/- 4.5 mmol L-1) and biochemical values between groups but temperature decreased in both groups. All animals needed antagonism of immobilization after 60 minutes. Recovery was quick and uneventful. There were no adverse effects after recovery.
Conclusion and clinical relevance Both anaesthetic protocols provided satisfactory immobilisation. There was no clear preference for either protocol and both appear suitable for CWD.},
  author       = {Bouts, Tim and Taylor, Polly and Berry, Karla and Routh, Andrew and Gasthuys, Frank},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keyword      = {dexmedetomidine,deer,ketamine,medetomidine,atipamezole},
  language     = {eng},
  number       = {2},
  pages        = {106--112},
  title        = {Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis)},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2010.00591.x},
  volume       = {38},
  year         = {2011},
}

Chicago
Bouts, Tim, Polly Taylor, Karla Berry, Andrew Routh, and Frank Gasthuys. 2011. “Evaluation of Medetomidine-ketamine and Dexmedetomidine-ketamine in Chinese Water Deer (Hydropotes Inermis).” Veterinary Anaesthesia and Analgesia 38 (2): 106–112.
APA
Bouts, T., Taylor, P., Berry, K., Routh, A., & Gasthuys, F. (2011). Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis). VETERINARY ANAESTHESIA AND ANALGESIA, 38(2), 106–112.
Vancouver
1.
Bouts T, Taylor P, Berry K, Routh A, Gasthuys F. Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis). VETERINARY ANAESTHESIA AND ANALGESIA. 2011;38(2):106–12.
MLA
Bouts, Tim, Polly Taylor, Karla Berry, et al. “Evaluation of Medetomidine-ketamine and Dexmedetomidine-ketamine in Chinese Water Deer (Hydropotes Inermis).” VETERINARY ANAESTHESIA AND ANALGESIA 38.2 (2011): 106–112. Print.