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Differences in HDL-cholesterol: apoA-I plus apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients

SS Soedamah-Muthu, HM Colhoun, MR Taskinen, B Idzior-Walus, JH Fuller and Raoul Rottiers (2000) DIABETOLOGIA. 43(11). p.1353-1359
abstract
Aims/hypothesis. To examine whether the HDL-cholesterol:apoA-I + apoA-II ratio and the epsilon2 allele are related to albuminuria at baseline and whether they are risk factors for progression of albuminuria in a cohort study of patients with Type I (insulin-dependent) diabetes mellitus. Methods. At baseline, the study cohort comprised 617 patients, aged 15-60 years, from seven European diabetic centres of the EURODIAB study. Albumin excretion rate, measured in a central laboratory, was categorised as normoalbuminuria at 20 mug/min or less, microalbuminuria between 20 and 200 mug/min or macroalbuminuria at 200 mug/min or over. Of the 250 patients who were normoalbuminuric at baseline and had follow-up albuminuria measurements, 34 patients were defined as early progressors. Results. At baseline, the mean HDL-cholesterol:apoA-I + apoA-II ratio was lower in macroalbuminuric patients (0.79, 95% CI:0.74-0.83) compared with normoalbuminuric (0.88, 95% CI:0.87-0.90) patients (p = 0.0002, adjusted for age and sex). At follow-up, 34 patients who progressed from normoalbuminuria to microalbuminuria or macroalbuminuria also had a slightly lower baseline ratio (0.85, 95% CI:0.80-0.89) than those 216 who remained normoalbuminuric (0.89, 95% CI:0.87-0.92) (adjusted p = 0.08). Neither of these relations were independent of LDL-cholesterol or fasting triglyceride. There was no association of the epsilon2 allele with albuminuria either at baseline (OR = 1.4, 95% CI:0.7-2.8) or with progression of albuminuria (OR = 0.4, 95% CI:0.1-3.5). Conclusion/interpretation. There is an inverse relation of HDL-cholesterol:apoA-I + apoA-II ratio with albuminuria at baseline. This lower ratio in microalbuminuric or macroalbuminuric patients could contribute to the increased risk of cardiovascular disease associated with nephropathy. There is weak evidence that HDL-composition is a risk factor for progression of albuminuria and no association of the epsilon2 allele with diabetic nephropathy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
A-I, IDDM PATIENTS, DENSITY LIPOPROTEIN CHOLESTEROL, APOLIPOPROTEIN-E POLYMORPHISM, ESTER TRANSFER, RISK-FACTORS, EPSILON-2 ALLELE, URINARY ALBUMIN, SERUM-LIPIDS, NEPHROPATHY, HDL-cholesterol, apolipoprotein E phenotype, epsilon 2 allele, apolipoproteins, albuminuria, Type I diabetes, apolipoprotein A-I, apolipoprotein A-II, diabetic nephropathy, progression
journal title
DIABETOLOGIA
Diabetologia
volume
43
issue
11
pages
1353 - 1359
Web of Science type
Article
Web of Science id
000165416600003
ISSN
0012-186X
DOI
10.1007/s001250051538
language
English
UGent publication?
yes
classification
A1
id
126674
handle
http://hdl.handle.net/1854/LU-126674
date created
2004-01-14 13:36:00
date last changed
2016-12-19 15:37:49
@article{126674,
  abstract     = {Aims/hypothesis. To examine whether the HDL-cholesterol:apoA-I + apoA-II ratio and the epsilon2 allele are related to albuminuria at baseline and whether they are risk factors for progression of albuminuria in a cohort study of patients with Type I (insulin-dependent) diabetes mellitus. Methods. At baseline, the study cohort comprised 617 patients, aged 15-60 years, from seven European diabetic centres of the EURODIAB study. Albumin excretion rate, measured in a central laboratory, was categorised as normoalbuminuria at 20 mug/min or less, microalbuminuria between 20 and 200 mug/min or macroalbuminuria at 200 mug/min or over. Of the 250 patients who were normoalbuminuric at baseline and had follow-up albuminuria measurements, 34 patients were defined as early progressors. Results. At baseline, the mean HDL-cholesterol:apoA-I + apoA-II ratio was lower in macroalbuminuric patients (0.79, 95\% CI:0.74-0.83) compared with normoalbuminuric (0.88, 95\% CI:0.87-0.90) patients (p = 0.0002, adjusted for age and sex). At follow-up, 34 patients who progressed from normoalbuminuria to microalbuminuria or macroalbuminuria also had a slightly lower baseline ratio (0.85, 95\% CI:0.80-0.89) than those 216 who remained normoalbuminuric (0.89, 95\% CI:0.87-0.92) (adjusted p = 0.08). Neither of these relations were independent of LDL-cholesterol or fasting triglyceride. There was no association of the epsilon2 allele with albuminuria either at baseline (OR = 1.4, 95\% CI:0.7-2.8) or with progression of albuminuria (OR = 0.4, 95\% CI:0.1-3.5). Conclusion/interpretation. There is an inverse relation of HDL-cholesterol:apoA-I + apoA-II ratio with albuminuria at baseline. This lower ratio in microalbuminuric or macroalbuminuric patients could contribute to the increased risk of cardiovascular disease associated with nephropathy. There is weak evidence that HDL-composition is a risk factor for progression of albuminuria and no association of the epsilon2 allele with diabetic nephropathy.},
  author       = {Soedamah-Muthu, SS and Colhoun, HM and Taskinen, MR and Idzior-Walus, B and Fuller, JH and Rottiers, Raoul},
  issn         = {0012-186X},
  journal      = {DIABETOLOGIA},
  keyword      = {A-I,IDDM PATIENTS,DENSITY LIPOPROTEIN CHOLESTEROL,APOLIPOPROTEIN-E POLYMORPHISM,ESTER TRANSFER,RISK-FACTORS,EPSILON-2 ALLELE,URINARY ALBUMIN,SERUM-LIPIDS,NEPHROPATHY,HDL-cholesterol,apolipoprotein E phenotype,epsilon 2 allele,apolipoproteins,albuminuria,Type I diabetes,apolipoprotein A-I,apolipoprotein A-II,diabetic nephropathy,progression},
  language     = {eng},
  number       = {11},
  pages        = {1353--1359},
  title        = {Differences in HDL-cholesterol: apoA-I plus apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients},
  url          = {http://dx.doi.org/10.1007/s001250051538},
  volume       = {43},
  year         = {2000},
}

Chicago
Soedamah-Muthu, SS, HM Colhoun, MR Taskinen, B Idzior-Walus, JH Fuller, and Raoul Rottiers. 2000. “Differences in HDL-cholesterol: apoA-I Plus apoA-II Ratio and apoE Phenotype with Albuminuric Status in Type I Diabetic Patients.” Diabetologia 43 (11): 1353–1359.
APA
Soedamah-Muthu, S., Colhoun, H., Taskinen, M., Idzior-Walus, B., Fuller, J., & Rottiers, R. (2000). Differences in HDL-cholesterol: apoA-I plus apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients. DIABETOLOGIA, 43(11), 1353–1359.
Vancouver
1.
Soedamah-Muthu S, Colhoun H, Taskinen M, Idzior-Walus B, Fuller J, Rottiers R. Differences in HDL-cholesterol: apoA-I plus apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients. DIABETOLOGIA. 2000;43(11):1353–9.
MLA
Soedamah-Muthu, SS, HM Colhoun, MR Taskinen, et al. “Differences in HDL-cholesterol: apoA-I Plus apoA-II Ratio and apoE Phenotype with Albuminuric Status in Type I Diabetic Patients.” DIABETOLOGIA 43.11 (2000): 1353–1359. Print.