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FDG uptake in primary squamous cell carcinoma of the head and neck : the relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis

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Abstract
Aim: This study aimed at assessing the relationship between over-expression of glucose transporters and hexokinases, tumour proliferation and apoptosis corrected for cellularity and partial volume corrected (pvc) FDG SUV values in primary squamous cell carcinoma of the head and neck (pSCCHN). Patients, methods: In 27 consecutive patients suffering from pSCCHN, FDG SUVmax and mean pvc values of the primary tumour were derived from a pre-surgical routine staging FDG PET/CT examination. GLUT-1, GLUT-3, HK-1, HK-3 expression, tumour proliferation (Ki-67 staining) and the number of apoptotic cells (cleaved caspase-3 staining), corrected for tumour cellularity, were subsequently assessed on the corresponding post-surgically obtained biopsies and tumour specimens. FDG SUVmax and mean pvc values of pSCCHN were correlated with the corresponding histological findings. Results: FDG SUVmax and mean pvc values correlated significantly: with GLUT-1 scores r = 0.408 (p = 0.04) and r = 0.439 (p = 0.03) as well as with the number of apoptotic cells r = 0.529 (p = 0.008) and r = 0.484 (p = 0.017). The number of apoptotic cells also correlated to GLUT-3 scores: r = 0.62 (p = 0.001) and GLUT-1 scores r = 0.528 (p = 0.008). Conclusion: FDG SUV pvc proved significantly related to GLUT-1 expression by tumour cells and to the absolute number of apoptotic cells. The latter finding warrants further exploration and confirmation by additional studies.
Keywords
head and neck, apoptosis, squamous cell carcinoma, FDG-PET/CT, GLUT-1, EXPRESSION, METABOLISM, CANCER, IN-VITRO, F-18-FDG PET, RECURRENT HEAD, POSITRON-EMISSION-TOMOGRAPHY, STANDARDIZED UPTAKE VALUE, PARTIAL VOLUME CORRECTION

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Citation

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Chicago
Deron, Philippe, CHRISTEL VANGESTEL, Ingeborg Goethals, ALEXANDRA DE POTTER, Marc Peeters, Hubert Vermeersch, and Christophe Van De Wiele. 2011. “FDG Uptake in Primary Squamous Cell Carcinoma of the Head and Neck : the Relationship Between Overexpression of Glucose Transporters and Hexokinases, Tumour Proliferation and Apoptosis.” Nuklearmedizin-nuclear Medicine 50 (1): 15–21.
APA
Deron, P., VANGESTEL, C., Goethals, I., DE POTTER, A., Peeters, M., Vermeersch, H., & Van De Wiele, C. (2011). FDG uptake in primary squamous cell carcinoma of the head and neck : the relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis. NUKLEARMEDIZIN-NUCLEAR MEDICINE, 50(1), 15–21.
Vancouver
1.
Deron P, VANGESTEL C, Goethals I, DE POTTER A, Peeters M, Vermeersch H, et al. FDG uptake in primary squamous cell carcinoma of the head and neck : the relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis. NUKLEARMEDIZIN-NUCLEAR MEDICINE. 2011;50(1):15–21.
MLA
Deron, Philippe, CHRISTEL VANGESTEL, Ingeborg Goethals, et al. “FDG Uptake in Primary Squamous Cell Carcinoma of the Head and Neck : the Relationship Between Overexpression of Glucose Transporters and Hexokinases, Tumour Proliferation and Apoptosis.” NUKLEARMEDIZIN-NUCLEAR MEDICINE 50.1 (2011): 15–21. Print.
@article{1262596,
  abstract     = {Aim: This study aimed at assessing the relationship between over-expression of glucose transporters and hexokinases, tumour proliferation and apoptosis corrected for cellularity and partial volume corrected (pvc) FDG SUV values in primary squamous cell carcinoma of the head and neck (pSCCHN). Patients, methods: In 27 consecutive patients suffering from pSCCHN, FDG SUVmax and mean pvc values of the primary tumour were derived from a pre-surgical routine staging FDG PET/CT examination. GLUT-1, GLUT-3, HK-1, HK-3 expression, tumour proliferation (Ki-67 staining) and the number of apoptotic cells (cleaved caspase-3 staining), corrected for tumour cellularity, were subsequently assessed on the corresponding post-surgically obtained biopsies and tumour specimens. FDG SUVmax and mean pvc values of pSCCHN were correlated with the corresponding histological findings. Results: FDG SUVmax and mean pvc values correlated significantly: with GLUT-1 scores r = 0.408 (p = 0.04) and r = 0.439 (p = 0.03) as well as with the number of apoptotic cells r = 0.529 (p = 0.008) and r = 0.484 (p = 0.017). The number of apoptotic cells also correlated to GLUT-3 scores: r = 0.62 (p = 0.001) and GLUT-1 scores r = 0.528 (p = 0.008). Conclusion: FDG SUV pvc proved significantly related to GLUT-1 expression by tumour cells and to the absolute number of apoptotic cells. The latter finding warrants further exploration and confirmation by additional studies.},
  author       = {Deron, Philippe and VANGESTEL, CHRISTEL and Goethals, Ingeborg and DE POTTER, ALEXANDRA and Peeters, Marc and Vermeersch, Hubert and Van De Wiele, Christophe},
  issn         = {0029-5566},
  journal      = {NUKLEARMEDIZIN-NUCLEAR MEDICINE},
  keyword      = {head and neck,apoptosis,squamous cell carcinoma,FDG-PET/CT,GLUT-1,EXPRESSION,METABOLISM,CANCER,IN-VITRO,F-18-FDG PET,RECURRENT HEAD,POSITRON-EMISSION-TOMOGRAPHY,STANDARDIZED UPTAKE VALUE,PARTIAL VOLUME CORRECTION},
  language     = {eng},
  number       = {1},
  pages        = {15--21},
  title        = {FDG uptake in primary squamous cell carcinoma of the head and neck : the relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis},
  volume       = {50},
  year         = {2011},
}

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