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FDG uptake in primary squamous cell carcinoma of the head and neck: the relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis

Philippe Deron UGent, CHRISTEL VANGESTEL UGent, Ingeborg Goethals UGent, ALEXANDRA DE POTTER UGent, Marc Peeters UGent, Hubert Vermeersch UGent and Christophe Van De Wiele UGent (2011) NUKLEARMEDIZIN-NUCLEAR MEDICINE. 50(1). p.15-21
abstract
Aim: This study aimed at assessing the relationship between over-expression of glucose transporters and hexokinases, tumour proliferation and apoptosis corrected for cellularity and partial volume corrected (pvc) FDG SUV values in primary squamous cell carcinoma of the head and neck (pSCCHN). Patients, methods: In 27 consecutive patients suffering from pSCCHN, FDG SUVmax and mean pvc values of the primary tumour were derived from a pre-surgical routine staging FDG PET/CT examination. GLUT-1, GLUT-3, HK-1, HK-3 expression, tumour proliferation (Ki-67 staining) and the number of apoptotic cells (cleaved caspase-3 staining), corrected for tumour cellularity, were subsequently assessed on the corresponding post-surgically obtained biopsies and tumour specimens. FDG SUVmax and mean pvc values of pSCCHN were correlated with the corresponding histological findings. Results: FDG SUVmax and mean pvc values correlated significantly: with GLUT-1 scores r = 0.408 (p = 0.04) and r = 0.439 (p = 0.03) as well as with the number of apoptotic cells r = 0.529 (p = 0.008) and r = 0.484 (p = 0.017). The number of apoptotic cells also correlated to GLUT-3 scores: r = 0.62 (p = 0.001) and GLUT-1 scores r = 0.528 (p = 0.008). Conclusion: FDG SUV pvc proved significantly related to GLUT-1 expression by tumour cells and to the absolute number of apoptotic cells. The latter finding warrants further exploration and confirmation by additional studies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
head and neck, apoptosis, squamous cell carcinoma, FDG-PET/CT, GLUT-1, EXPRESSION, METABOLISM, CANCER, IN-VITRO, F-18-FDG PET, RECURRENT HEAD, POSITRON-EMISSION-TOMOGRAPHY, STANDARDIZED UPTAKE VALUE, PARTIAL VOLUME CORRECTION
journal title
NUKLEARMEDIZIN-NUCLEAR MEDICINE
Nuklearmedizin
volume
50
issue
1
pages
15 - 21
Web of Science type
Article
Web of Science id
000288624800006
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.28 (2011)
JCR rank
80/116 (2011)
JCR quartile
3 (2011)
ISSN
0029-5566
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1262596
handle
http://hdl.handle.net/1854/LU-1262596
date created
2011-06-15 09:21:21
date last changed
2011-06-21 09:01:32
@article{1262596,
  abstract     = {Aim: This study aimed at assessing the relationship between over-expression of glucose transporters and hexokinases, tumour proliferation and apoptosis corrected for cellularity and partial volume corrected (pvc) FDG SUV values in primary squamous cell carcinoma of the head and neck (pSCCHN). Patients, methods: In 27 consecutive patients suffering from pSCCHN, FDG SUVmax and mean pvc values of the primary tumour were derived from a pre-surgical routine staging FDG PET/CT examination. GLUT-1, GLUT-3, HK-1, HK-3 expression, tumour proliferation (Ki-67 staining) and the number of apoptotic cells (cleaved caspase-3 staining), corrected for tumour cellularity, were subsequently assessed on the corresponding post-surgically obtained biopsies and tumour specimens. FDG SUVmax and mean pvc values of pSCCHN were correlated with the corresponding histological findings. Results: FDG SUVmax and mean pvc values correlated significantly: with GLUT-1 scores r = 0.408 (p = 0.04) and r = 0.439 (p = 0.03) as well as with the number of apoptotic cells r = 0.529 (p = 0.008) and r = 0.484 (p = 0.017). The number of apoptotic cells also correlated to GLUT-3 scores: r = 0.62 (p = 0.001) and GLUT-1 scores r = 0.528 (p = 0.008). Conclusion: FDG SUV pvc proved significantly related to GLUT-1 expression by tumour cells and to the absolute number of apoptotic cells. The latter finding warrants further exploration and confirmation by additional studies.},
  author       = {Deron, Philippe and VANGESTEL, CHRISTEL and Goethals, Ingeborg and DE POTTER, ALEXANDRA and Peeters, Marc and Vermeersch, Hubert and Van De Wiele, Christophe},
  issn         = {0029-5566},
  journal      = {NUKLEARMEDIZIN-NUCLEAR MEDICINE},
  keyword      = {head and neck,apoptosis,squamous cell carcinoma,FDG-PET/CT,GLUT-1,EXPRESSION,METABOLISM,CANCER,IN-VITRO,F-18-FDG PET,RECURRENT HEAD,POSITRON-EMISSION-TOMOGRAPHY,STANDARDIZED UPTAKE VALUE,PARTIAL VOLUME CORRECTION},
  language     = {eng},
  number       = {1},
  pages        = {15--21},
  title        = {FDG uptake in primary squamous cell carcinoma of the head and neck: the relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis},
  volume       = {50},
  year         = {2011},
}

Chicago
DERON, PHILIPPE, CHRISTEL VANGESTEL, Ingeborg Goethals, ALEXANDRA DE POTTER, Marc Peeters, Hubert Vermeersch, and Christophe Van De Wiele. 2011. “FDG Uptake in Primary Squamous Cell Carcinoma of the Head and Neck: The Relationship Between Overexpression of Glucose Transporters and Hexokinases, Tumour Proliferation and Apoptosis.” Nuklearmedizin-nuclear Medicine 50 (1): 15–21.
APA
DERON, P., VANGESTEL, C., Goethals, I., DE POTTER, A., Peeters, M., Vermeersch, H., & Van De Wiele, C. (2011). FDG uptake in primary squamous cell carcinoma of the head and neck: the relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis. NUKLEARMEDIZIN-NUCLEAR MEDICINE, 50(1), 15–21.
Vancouver
1.
DERON P, VANGESTEL C, Goethals I, DE POTTER A, Peeters M, Vermeersch H, et al. FDG uptake in primary squamous cell carcinoma of the head and neck: the relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis. NUKLEARMEDIZIN-NUCLEAR MEDICINE. 2011;50(1):15–21.
MLA
DERON, PHILIPPE, CHRISTEL VANGESTEL, Ingeborg Goethals, et al. “FDG Uptake in Primary Squamous Cell Carcinoma of the Head and Neck: The Relationship Between Overexpression of Glucose Transporters and Hexokinases, Tumour Proliferation and Apoptosis.” NUKLEARMEDIZIN-NUCLEAR MEDICINE 50.1 (2011): 15–21. Print.