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Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain

Jonas Claeys, Koen Mertens, Yves D'Asseler and Ingeborg Goethals UGent (2010) ANNALS OF NUCLEAR MEDICINE. 24(6). p.501-505
abstract
The aim of this study was to investigate whether normoglycemic glucose concentrations interfere with cerebral F-18 FDG uptake. The analysis was based on 2 sets of paired PET scans in 94 patients who were in complete metabolic remission after the successful completion of treatment for lymphoma. For these 188 PET scans, 2 subgroups were defined according to the plasma glucose level at the time of scanning. Group 1 contained the PET images that were associated with the lower of both normoglycemic plasma glucose levels, whereas group 2 contained the PET images that were associated with the higher of both plasma glucose levels. SUVs (standard uptake values) in the cerebellum between both groups were compared using paired sample T test. Subsequently, SUVs were normalized to a standard glucose concentration and normalized SUVs were again compared. Further, we calculated the coefficient of variation of SUVs in group 1 and 2 both before and after the normalization step. Mean plasma glucose level was 86 mg/dL (SD of 9 mg/dL) in group 1 and 97 mg/dL (SD of 10 mg/dL) in group 2. Mean SUV was 3.8 (SD of 1.1) for group 1 and 3.5 (SD of 1.1) for group 2. Mean SUV in group 1 was slightly but statistically significantly higher than the mean SUV in group 2 (p < 0.01). Mean normalized SUV was 3.6 (SD of 1.1) in group 1 and 3.7 (SD of 1.3) in group 2. A paired comparison between normalized SUVs in both groups indicated that there was no statistically significant difference (p < 0.31). The coefficient of variation for the SUVs in group 1 and 2 before normalization was 29 and 30%, respectively. The coefficient of variation for the normalized SUVs in group 1 and 2 was 30 and 34%, respectively. Our results indicated that plasma glucose levels that are within the normoglycemic range have a small but systematic effect on F-18 FDG uptake in the brain (following an inverse relationship). Normalizing plasma glucose levels to a standard glucose concentration successfully reduced the intra-subject variability of SUV measures. Inter-subject variability, however, remained high suggesting that other factors have an influence as well.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
STANDARDIZED UPTAKE VALUES, SUV, CEREBRAL-BLOOD-FLOW, METABOLIC MEASUREMENTS, PET, HYPERGLYCEMIA, VARIABILITY, Brain metabolism, Normoglycemia, QUANTIFICATION, INSULIN, ANXIETY, TUMORS
journal title
ANNALS OF NUCLEAR MEDICINE
Ann. Nucl. Med.
volume
24
issue
6
pages
501 - 505
Web of Science type
Article
Web of Science id
000280064800011
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.386 (2010)
JCR rank
71/111 (2010)
JCR quartile
3 (2010)
ISSN
0914-7187
DOI
10.1007/s12149-010-0359-9
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1262576
handle
http://hdl.handle.net/1854/LU-1262576
date created
2011-06-15 09:14:44
date last changed
2016-12-19 15:42:15
@article{1262576,
  abstract     = {The aim of this study was to investigate whether normoglycemic glucose concentrations interfere with cerebral F-18 FDG uptake.
The analysis was based on 2 sets of paired PET scans in 94 patients who were in complete metabolic remission after the successful completion of treatment for lymphoma. For these 188 PET scans, 2 subgroups were defined according to the plasma glucose level at the time of scanning. Group 1 contained the PET images that were associated with the lower of both normoglycemic plasma glucose levels, whereas group 2 contained the PET images that were associated with the higher of both plasma glucose levels. SUVs (standard uptake values) in the cerebellum between both groups were compared using paired sample T test. Subsequently, SUVs were normalized to a standard glucose concentration and normalized SUVs were again compared. Further, we calculated the coefficient of variation of SUVs in group 1 and 2 both before and after the normalization step.
Mean plasma glucose level was 86 mg/dL (SD of 9 mg/dL) in group 1 and 97 mg/dL (SD of 10 mg/dL) in group 2. Mean SUV was 3.8 (SD of 1.1) for group 1 and 3.5 (SD of 1.1) for group 2. Mean SUV in group 1 was slightly but statistically significantly higher than the mean SUV in group 2 (p {\textlangle} 0.01). Mean normalized SUV was 3.6 (SD of 1.1) in group 1 and 3.7 (SD of 1.3) in group 2. A paired comparison between normalized SUVs in both groups indicated that there was no statistically significant difference (p {\textlangle} 0.31). The coefficient of variation for the SUVs in group 1 and 2 before normalization was 29 and 30\%, respectively. The coefficient of variation for the normalized SUVs in group 1 and 2 was 30 and 34\%, respectively.
Our results indicated that plasma glucose levels that are within the normoglycemic range have a small but systematic effect on F-18 FDG uptake in the brain (following an inverse relationship). Normalizing plasma glucose levels to a standard glucose concentration successfully reduced the intra-subject variability of SUV measures. Inter-subject variability, however, remained high suggesting that other factors have an influence as well.},
  author       = {Claeys, Jonas and Mertens, Koen and D'Asseler, Yves and Goethals, Ingeborg},
  issn         = {0914-7187},
  journal      = {ANNALS OF NUCLEAR MEDICINE},
  keyword      = {STANDARDIZED UPTAKE VALUES,SUV,CEREBRAL-BLOOD-FLOW,METABOLIC MEASUREMENTS,PET,HYPERGLYCEMIA,VARIABILITY,Brain metabolism,Normoglycemia,QUANTIFICATION,INSULIN,ANXIETY,TUMORS},
  language     = {eng},
  number       = {6},
  pages        = {501--505},
  title        = {Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain},
  url          = {http://dx.doi.org/10.1007/s12149-010-0359-9},
  volume       = {24},
  year         = {2010},
}

Chicago
Claeys, Jonas, Koen Mertens, YVES D’ASSELER, and Ingeborg Goethals. 2010. “Normoglycemic Plasma Glucose Levels Affect F-18 FDG Uptake in the Brain.” Annals of Nuclear Medicine 24 (6): 501–505.
APA
Claeys, Jonas, Mertens, K., D’ASSELER, Y., & Goethals, I. (2010). Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain. ANNALS OF NUCLEAR MEDICINE, 24(6), 501–505.
Vancouver
1.
Claeys J, Mertens K, D’ASSELER Y, Goethals I. Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain. ANNALS OF NUCLEAR MEDICINE. 2010;24(6):501–5.
MLA
Claeys, Jonas, Koen Mertens, YVES D’ASSELER, et al. “Normoglycemic Plasma Glucose Levels Affect F-18 FDG Uptake in the Brain.” ANNALS OF NUCLEAR MEDICINE 24.6 (2010): 501–505. Print.