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Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain

(2010) ANNALS OF NUCLEAR MEDICINE. 24(6). p.501-505
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Abstract
The aim of this study was to investigate whether normoglycemic glucose concentrations interfere with cerebral F-18 FDG uptake. The analysis was based on 2 sets of paired PET scans in 94 patients who were in complete metabolic remission after the successful completion of treatment for lymphoma. For these 188 PET scans, 2 subgroups were defined according to the plasma glucose level at the time of scanning. Group 1 contained the PET images that were associated with the lower of both normoglycemic plasma glucose levels, whereas group 2 contained the PET images that were associated with the higher of both plasma glucose levels. SUVs (standard uptake values) in the cerebellum between both groups were compared using paired sample T test. Subsequently, SUVs were normalized to a standard glucose concentration and normalized SUVs were again compared. Further, we calculated the coefficient of variation of SUVs in group 1 and 2 both before and after the normalization step. Mean plasma glucose level was 86 mg/dL (SD of 9 mg/dL) in group 1 and 97 mg/dL (SD of 10 mg/dL) in group 2. Mean SUV was 3.8 (SD of 1.1) for group 1 and 3.5 (SD of 1.1) for group 2. Mean SUV in group 1 was slightly but statistically significantly higher than the mean SUV in group 2 (p < 0.01). Mean normalized SUV was 3.6 (SD of 1.1) in group 1 and 3.7 (SD of 1.3) in group 2. A paired comparison between normalized SUVs in both groups indicated that there was no statistically significant difference (p < 0.31). The coefficient of variation for the SUVs in group 1 and 2 before normalization was 29 and 30%, respectively. The coefficient of variation for the normalized SUVs in group 1 and 2 was 30 and 34%, respectively. Our results indicated that plasma glucose levels that are within the normoglycemic range have a small but systematic effect on F-18 FDG uptake in the brain (following an inverse relationship). Normalizing plasma glucose levels to a standard glucose concentration successfully reduced the intra-subject variability of SUV measures. Inter-subject variability, however, remained high suggesting that other factors have an influence as well.
Keywords
STANDARDIZED UPTAKE VALUES, SUV, CEREBRAL-BLOOD-FLOW, METABOLIC MEASUREMENTS, PET, HYPERGLYCEMIA, VARIABILITY, Brain metabolism, Normoglycemia, QUANTIFICATION, INSULIN, ANXIETY, TUMORS

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MLA
Claeys, Jonas, et al. “Normoglycemic Plasma Glucose Levels Affect F-18 FDG Uptake in the Brain.” ANNALS OF NUCLEAR MEDICINE, vol. 24, no. 6, 2010, pp. 501–05, doi:10.1007/s12149-010-0359-9.
APA
Claeys, J., Mertens, K., D’Asseler, Y., & Goethals, I. (2010). Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain. ANNALS OF NUCLEAR MEDICINE, 24(6), 501–505. https://doi.org/10.1007/s12149-010-0359-9
Chicago author-date
Claeys, Jonas, Koen Mertens, Yves D’Asseler, and Ingeborg Goethals. 2010. “Normoglycemic Plasma Glucose Levels Affect F-18 FDG Uptake in the Brain.” ANNALS OF NUCLEAR MEDICINE 24 (6): 501–5. https://doi.org/10.1007/s12149-010-0359-9.
Chicago author-date (all authors)
Claeys, Jonas, Koen Mertens, Yves D’Asseler, and Ingeborg Goethals. 2010. “Normoglycemic Plasma Glucose Levels Affect F-18 FDG Uptake in the Brain.” ANNALS OF NUCLEAR MEDICINE 24 (6): 501–505. doi:10.1007/s12149-010-0359-9.
Vancouver
1.
Claeys J, Mertens K, D’Asseler Y, Goethals I. Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain. ANNALS OF NUCLEAR MEDICINE. 2010;24(6):501–5.
IEEE
[1]
J. Claeys, K. Mertens, Y. D’Asseler, and I. Goethals, “Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain,” ANNALS OF NUCLEAR MEDICINE, vol. 24, no. 6, pp. 501–505, 2010.
@article{1262576,
  abstract     = {{The aim of this study was to investigate whether normoglycemic glucose concentrations interfere with cerebral F-18 FDG uptake.
The analysis was based on 2 sets of paired PET scans in 94 patients who were in complete metabolic remission after the successful completion of treatment for lymphoma. For these 188 PET scans, 2 subgroups were defined according to the plasma glucose level at the time of scanning. Group 1 contained the PET images that were associated with the lower of both normoglycemic plasma glucose levels, whereas group 2 contained the PET images that were associated with the higher of both plasma glucose levels. SUVs (standard uptake values) in the cerebellum between both groups were compared using paired sample T test. Subsequently, SUVs were normalized to a standard glucose concentration and normalized SUVs were again compared. Further, we calculated the coefficient of variation of SUVs in group 1 and 2 both before and after the normalization step.
Mean plasma glucose level was 86 mg/dL (SD of 9 mg/dL) in group 1 and 97 mg/dL (SD of 10 mg/dL) in group 2. Mean SUV was 3.8 (SD of 1.1) for group 1 and 3.5 (SD of 1.1) for group 2. Mean SUV in group 1 was slightly but statistically significantly higher than the mean SUV in group 2 (p < 0.01). Mean normalized SUV was 3.6 (SD of 1.1) in group 1 and 3.7 (SD of 1.3) in group 2. A paired comparison between normalized SUVs in both groups indicated that there was no statistically significant difference (p < 0.31). The coefficient of variation for the SUVs in group 1 and 2 before normalization was 29 and 30%, respectively. The coefficient of variation for the normalized SUVs in group 1 and 2 was 30 and 34%, respectively.
Our results indicated that plasma glucose levels that are within the normoglycemic range have a small but systematic effect on F-18 FDG uptake in the brain (following an inverse relationship). Normalizing plasma glucose levels to a standard glucose concentration successfully reduced the intra-subject variability of SUV measures. Inter-subject variability, however, remained high suggesting that other factors have an influence as well.}},
  author       = {{Claeys, Jonas and Mertens, Koen and D'Asseler, Yves and Goethals, Ingeborg}},
  issn         = {{0914-7187}},
  journal      = {{ANNALS OF NUCLEAR MEDICINE}},
  keywords     = {{STANDARDIZED UPTAKE VALUES,SUV,CEREBRAL-BLOOD-FLOW,METABOLIC MEASUREMENTS,PET,HYPERGLYCEMIA,VARIABILITY,Brain metabolism,Normoglycemia,QUANTIFICATION,INSULIN,ANXIETY,TUMORS}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{501--505}},
  title        = {{Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain}},
  url          = {{http://dx.doi.org/10.1007/s12149-010-0359-9}},
  volume       = {{24}},
  year         = {{2010}},
}

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