Advanced search

Repetitive analyses of P-glycoprotein in chronic myeloid leukaemia

(2000) ACTA CLINICA BELGICA. 55(4). p.215-221
Author
Organization
Abstract
P-glycoprotein, a pump located in the plasma cell membrane, extrudes several clinically important drugs from the cell, and hence causes multidrug resistance. Reversing clinical drug resistance is possible by using agents that inhibit the activity of P-glycoprotein. We describe the results of sequential flow cytometric determinations of P-glycoprotein expression and activity in two patients suffering from acute lymphoblastic transformation of chronic myeloid leukaemia. Neither P-glycoprotein expression, nor its activity could be detected in the initial sample of the first patient. In the second patient, no P-glycoprotein expression was found at diagnosis. However, after chemotherapy containing P-glycoprotein substrates, a significant expression was found in both patients and the functional flow cytometric test was positive. In order to achieve an accurate selection of patients that might benefit from the clinical use of P-gp inhibitors, repeated analyses are indicated in each patient suffering from acute leukaemia, during the course of the illness.
Keywords
P170 GLYCOPROTEIN, CONSENSUS RECOMMENDATIONS, DRUG-RESISTANCE, EXPRESSION, MALIGNANCIES, TRANSPORTER, TUMORS, GENE, MDR, P-glycoprotein, flow cytometry, chronic myeloid leukaemia, MULTIDRUG-RESISTANCE MDR1, ACUTE LYMPHOBLASTIC-LEUKEMIA

Citation

Please use this url to cite or link to this publication:

Chicago
De Moerloose, Barbara, A Muylaert, F Gemmel, Anne Janssens, Bruce Poppe, Catharina Dhooge, Werner Van Hove, and Jan Philippé. 2000. “Repetitive Analyses of P-glycoprotein in Chronic Myeloid Leukaemia.” Acta Clinica Belgica 55 (4): 215–221.
APA
De Moerloose, B., Muylaert, A., Gemmel, F., Janssens, A., Poppe, B., Dhooge, C., Van Hove, W., et al. (2000). Repetitive analyses of P-glycoprotein in chronic myeloid leukaemia. ACTA CLINICA BELGICA, 55(4), 215–221.
Vancouver
1.
De Moerloose B, Muylaert A, Gemmel F, Janssens A, Poppe B, Dhooge C, et al. Repetitive analyses of P-glycoprotein in chronic myeloid leukaemia. ACTA CLINICA BELGICA. 2000;55(4):215–21.
MLA
De Moerloose, Barbara, A Muylaert, F Gemmel, et al. “Repetitive Analyses of P-glycoprotein in Chronic Myeloid Leukaemia.” ACTA CLINICA BELGICA 55.4 (2000): 215–221. Print.
@article{126228,
  abstract     = {P-glycoprotein, a pump located in the plasma cell membrane, extrudes several clinically important drugs from the cell, and hence causes multidrug resistance. Reversing clinical drug resistance is possible by using agents that inhibit the activity of P-glycoprotein. We describe the results of sequential flow cytometric determinations of P-glycoprotein expression and activity in two patients suffering from acute lymphoblastic transformation of chronic myeloid leukaemia. Neither P-glycoprotein expression, nor its activity could be detected in the initial sample of the first patient. In the second patient, no P-glycoprotein expression was found at diagnosis. However, after chemotherapy containing P-glycoprotein substrates, a significant expression was found in both patients and the functional flow cytometric test was positive. In order to achieve an accurate selection of patients that might benefit from the clinical use of P-gp inhibitors, repeated analyses are indicated in each patient suffering from acute leukaemia, during the course of the illness.},
  author       = {De Moerloose, Barbara and Muylaert, A and Gemmel, F and Janssens, Anne and Poppe, Bruce and Dhooge, Catharina and Van Hove, Werner and Philippé, Jan},
  issn         = {0001-5512},
  journal      = {ACTA CLINICA BELGICA},
  keywords     = {P170 GLYCOPROTEIN,CONSENSUS RECOMMENDATIONS,DRUG-RESISTANCE,EXPRESSION,MALIGNANCIES,TRANSPORTER,TUMORS,GENE,MDR,P-glycoprotein,flow cytometry,chronic myeloid leukaemia,MULTIDRUG-RESISTANCE MDR1,ACUTE LYMPHOBLASTIC-LEUKEMIA},
  language     = {eng},
  number       = {4},
  pages        = {215--221},
  title        = {Repetitive analyses of P-glycoprotein in chronic myeloid leukaemia},
  volume       = {55},
  year         = {2000},
}

Web of Science
Times cited: