Ghent University Academic Bibliography

Advanced

The pathogenesis of EHV1 in horses: novel insights from experimental inoculations and field situations

Annick Gryspeerdt (2011)
abstract
Equine herpesvirus 1 (EHV1) is the most important cause of infectious abortion in horses worldwide and can also lead to severe nervous system disorders with frequent fatal outcome. Infection occurs via respiratory route and after local replication in tissues of the upper respiratory tract, the virus spreads via a cell-associated viremia to target internal organs such as the uterus or the nervous system. Secondary replication of EHV1 in endothelial cells of these organs can result in late term abortion or nervous system disorders. Vaccination with the currently available vaccines cannot prevent clinical symptoms such as abortion or nervous system disorders. Moreover, treatment of these symptoms is only supportive and specific medication is not available. Therefore, an improvement of existing vaccines and/or the development of therapies are necessary. Unfortunately, at the start of this thesis, several important steps in the pathogenesis of this disease were still not fully clarified, making it difficult to find new directions in the strategy to develop better vaccines and to create drugs that inhibit steps of the pathogenesis. In order to achieve this goal, studies in the natural host of EHV1, the horse, under both experimental and field conditions, are of paramount importance to obtain relevant and correct information about the pathogenesis of this disease. Firstly, a thorough knowledge of the complete pathogenesis from primary replication and invasion via cell-associated viremia to the target organs is urgent. Therefore, the first aim of this thesis was to gain a more detailed insight in the invasion of neurologic and non-neurologic strains of EHV1 from the upper respiratory tract to the carrier cells in the blood stream by means of experimental infection studies in horses (Chapter III). The second aim was to examine how individual EHV1-infected cells escape from immune effector mechanisms at the primary site of replication (Chapter IV). Secondly, to develop suitable vaccination and treatment strategies during natural occurring outbreaks of disease, field information about the epidemiology of the virus is needed. The third and last aim was therefore to gain more information about naturally occurring outbreaks in Belgium in terms of risk factors, protective properties of vaccination, the effect of experimental therapies and diagnosis (Chapter V).
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
Equine herpesvirus 1, late expression, early pathogenesis, natural outbreak
pages
170 pages
publisher
Ghent University. Faculty of Veterinary Medicine
place of publication
Merelbeke, Belgium
defense location
Merelbeke : Faculteit Diergeneeskunde (auditorium Hoogbouw)
defense date
2011-05-30 16:30
ISBN
9789058642554
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
1259986
handle
http://hdl.handle.net/1854/LU-1259986
date created
2011-06-10 14:49:36
date last changed
2011-06-14 08:49:01
@phdthesis{1259986,
  abstract     = {Equine herpesvirus 1 (EHV1) is the most important cause of infectious abortion in horses worldwide and can also lead to severe nervous system disorders with frequent fatal outcome. Infection occurs via respiratory route and after local replication in tissues of the upper respiratory tract, the virus spreads via a cell-associated viremia to target internal organs such as the uterus or the nervous system. Secondary replication of EHV1 in endothelial cells of these organs can result in late term abortion or nervous system disorders. Vaccination with the currently available vaccines cannot prevent clinical symptoms such as abortion or nervous system disorders. Moreover, treatment of these symptoms is only supportive and specific medication is not available. Therefore, an improvement of existing vaccines and/or the development of therapies are necessary. Unfortunately, at the start of this thesis, several important steps in the pathogenesis of this disease were still not fully clarified, making it difficult to find new directions in the strategy to develop better vaccines and to create drugs that inhibit steps of the pathogenesis. In order to achieve this goal, studies in the natural host of EHV1, the horse, under both experimental and field conditions, are of paramount importance to obtain relevant and correct information about the pathogenesis of this disease. Firstly, a thorough knowledge of the complete pathogenesis from primary replication and invasion via cell-associated viremia to the target organs is urgent. Therefore, the first aim of this thesis was to gain a more detailed insight in the invasion of neurologic and non-neurologic strains of EHV1 from the upper respiratory tract to the carrier cells in the blood stream by means of experimental infection studies in horses (Chapter III). The second aim was to examine how individual EHV1-infected cells escape from immune effector mechanisms at the primary site of replication (Chapter IV). Secondly, to develop suitable vaccination and treatment strategies during natural occurring outbreaks of disease, field information about the epidemiology of the virus is needed. The third and last aim was therefore to gain more information about naturally occurring outbreaks in Belgium in terms of risk factors, protective properties of vaccination, the effect of experimental therapies and diagnosis (Chapter V).},
  author       = {Gryspeerdt, Annick},
  isbn         = {9789058642554},
  keyword      = {Equine herpesvirus 1,late expression,early pathogenesis,natural outbreak},
  language     = {eng},
  pages        = {170},
  publisher    = {Ghent University. Faculty of Veterinary Medicine},
  school       = {Ghent University},
  title        = {The pathogenesis of EHV1 in horses: novel insights from experimental inoculations and field situations},
  year         = {2011},
}

Chicago
Gryspeerdt, Annick. 2011. “The Pathogenesis of EHV1 in Horses: Novel Insights from Experimental Inoculations and Field Situations”. Merelbeke, Belgium: Ghent University. Faculty of Veterinary Medicine.
APA
Gryspeerdt, A. (2011). The pathogenesis of EHV1 in horses: novel insights from experimental inoculations and field situations. Ghent University. Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vancouver
1.
Gryspeerdt A. The pathogenesis of EHV1 in horses: novel insights from experimental inoculations and field situations. [Merelbeke, Belgium]: Ghent University. Faculty of Veterinary Medicine; 2011.
MLA
Gryspeerdt, Annick. “The Pathogenesis of EHV1 in Horses: Novel Insights from Experimental Inoculations and Field Situations.” 2011 : n. pag. Print.