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New N-alkylamides from Anacyclus pyrethrum

(2011) PLANTA MEDICA. 77(12). p.1355-1355
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Abstract
The roots of Anacyclus pyrethrum DC (Asteraceae) are frequently used in traditional medicine e.g. as aphrodisiac [1]. Depending on the extraction method and solvent, different yields of N-alkylamide constituents can be found, possibly resulting in alterations in biological effects and toxicity. Therefore, analytical profiling of the bio-active N-alkylamides in these plant preparations is an inevitable quality parameter, with liquid chromatography-electrospray mass spectrometry (HPLC/ESI-MS) as recommended technique for comprehensive analysis of alkylamides in plant extracts [2-4].An N-alkylamide profiling from an ethanolic Anacyclus pyrethrum root extract was performed using a gradient reversed phase HPLC/ESI-MS method on an embedded polar column. MS1 and MS2 fragmentation data were used for identification purposes, while UV was used for quantification. Thirteen N-alkylamides (five N-isobutylamides, three N-methyl isobutylamides, four tyramides and one 2-phenylethylamide) were detected. Five of are novel compounds, which have never been identified in Anacyclus pyrethrum or other plants: Acknowledgements: Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen) (no. 091257) and the All India Council for Technical Education, New Delhi, India. References: 1. Sharma, V., Thakur, M., Chauhan, N., Dixit, V. 2010 Planta Med 76:1214-1214. 2. Sharma, V., Boonen, J., Chauhan, N., Thakur, M. De Spiegeleer, B., Dixit, V. 2011 Phytomedicine, In press. 3. Kartal, M., Kan, Y., Gulpinar, A. R. 2007 Planta Med 73:253. 4. Boonen, J., Baert, B., Burvenich, C., Blondeel, P., De Saeger, S., De Spiegeleer, B. 2010 J Pharmaceut Biomed 53:243-249.

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Citation

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MLA
Boonen, Jente, et al. “New N-Alkylamides from Anacyclus Pyrethrum.” PLANTA MEDICA, vol. 77, no. 12, 2011, pp. 1355–1355.
APA
Boonen, J., Sharma, V., Dixit, V., & De Spiegeleer, B. (2011). New N-alkylamides from Anacyclus pyrethrum. In PLANTA MEDICA (Vol. 77, pp. 1355–1355). Antalya, Turkey.
Chicago author-date
Boonen, Jente, Vikas Sharma, Vinot Dixit, and Bart De Spiegeleer. 2011. “New N-Alkylamides from Anacyclus Pyrethrum.” In PLANTA MEDICA, 77:1355–1355.
Chicago author-date (all authors)
Boonen, Jente, Vikas Sharma, Vinot Dixit, and Bart De Spiegeleer. 2011. “New N-Alkylamides from Anacyclus Pyrethrum.” In PLANTA MEDICA, 77:1355–1355.
Vancouver
1.
Boonen J, Sharma V, Dixit V, De Spiegeleer B. New N-alkylamides from Anacyclus pyrethrum. In: PLANTA MEDICA. 2011. p. 1355–1355.
IEEE
[1]
J. Boonen, V. Sharma, V. Dixit, and B. De Spiegeleer, “New N-alkylamides from Anacyclus pyrethrum,” in PLANTA MEDICA, Antalya, Turkey, 2011, vol. 77, no. 12, pp. 1355–1355.
@inproceedings{1252668,
  abstract     = {The roots of Anacyclus pyrethrum DC (Asteraceae) are frequently used in traditional medicine e.g. as aphrodisiac [1]. Depending on the extraction method and solvent, different yields of N-alkylamide constituents can be found, possibly resulting in alterations in biological effects and toxicity. Therefore, analytical profiling of the bio-active N-alkylamides in these plant preparations is an inevitable quality parameter, with liquid chromatography-electrospray mass spectrometry (HPLC/ESI-MS) as recommended technique for comprehensive analysis of alkylamides in plant extracts [2-4].An N-alkylamide profiling from an ethanolic Anacyclus pyrethrum root extract was performed using a gradient reversed phase HPLC/ESI-MS method on an embedded polar column. MS1 and MS2 fragmentation data were used for identification purposes, while UV was used for quantification. Thirteen N-alkylamides (five N-isobutylamides, three N-methyl isobutylamides, four tyramides and one 2-phenylethylamide) were detected. Five of are novel compounds, which have never been identified in Anacyclus pyrethrum or other plants: Acknowledgements: Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen) (no. 091257) and the All India Council for Technical Education, New Delhi, India. References: 1. Sharma, V., Thakur, M., Chauhan, N., Dixit, V. 2010 Planta Med 76:1214-1214. 2. Sharma, V., Boonen, J., Chauhan, N., Thakur, M. De Spiegeleer, B., Dixit, V. 2011 Phytomedicine, In press.
3. Kartal, M., Kan, Y., Gulpinar, A. R. 2007 Planta Med 73:253. 4. Boonen, J., Baert, B., Burvenich, C., Blondeel, P., De Saeger, S., De Spiegeleer, B. 2010 J Pharmaceut Biomed 53:243-249.},
  author       = {Boonen, Jente and Sharma, Vikas and Dixit, Vinot and De Spiegeleer, Bart},
  booktitle    = {PLANTA MEDICA},
  issn         = {0032-0943},
  language     = {eng},
  location     = {Antalya, Turkey},
  number       = {12},
  pages        = {1355--1355},
  title        = {New N-alkylamides from Anacyclus pyrethrum},
  volume       = {77},
  year         = {2011},
}

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