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The ROOT MERISTEMLESS1/CADMIUM SENSITIVE2 gene defines a glutathione-dependent pathway involved in initiation and maintenance of cell division during postembryonic root development

Teva Vernoux, Robert C Wilson, Kevin A Seeley, Jean-Philippe Reichheld UGent, Sandra Muroy, Spencer Brown, Spencer C Maughan, Christopher S Cobbett, Marc Van Montagu UGent, Dirk Inzé UGent, et al. (2000) PLANT CELL. 12(1). p.97-109
abstract
Activation of cell division in the root apical meristem after germination is essential for postembryonic root development. Arabidopsis plants homozygous for a mutation in the ROOT MERISTEMLESS1 (RML1) gene are unable to establish an active postembryonic meristem in the root apex, This mutation abolishes cell division in the root but not in the shoot. We report the molecular cloning of the RML1 gene, which encodes the first enzyme of glutathione (GSH) biosynthesis, gamma-glutamylcysteine synthetase, and which is allelic to CADMIUM SENSITIVE2. The phenotype of the rml1 mutant, which was also evident in the roots of wild-type Arabidopsis and tobacco treated with an inhibitor of GSH biosynthesis, could be relieved by applying GSH to rml1 seedlings. By using a synchronized tobacco cell suspension culture, we showed that the G(1)-to-S phase transition requires an adequate level of GSH, These observations suggest the existence of a GSH-dependent developmental pathway essential for initiation and maintenance of cell division during postembryonic root development.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ACTIVATION, MODULATION, DEFICIENT, EXPRESSION, ORGANIZATION, MERISTEM, BINDING-ACTIVITY, PLANT DEVELOPMENT, GAMMA-GLUTAMYLCYSTEINE SYNTHETASE, ARABIDOPSIS-THALIANA
journal title
PLANT CELL
Plant Cell
volume
12
issue
1
pages
97 - 109
Web of Science type
Article
Web of Science id
000085061300007
ISSN
1040-4651
DOI
10.1105/tpc.12.1.97
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally to the work
copyright statement
I have transferred the copyright for this publication to the publisher
id
125044
handle
http://hdl.handle.net/1854/LU-125044
date created
2004-01-14 13:36:00
date last changed
2016-12-19 15:37:49
@article{125044,
  abstract     = {Activation of cell division in the root apical meristem after germination is essential for postembryonic root development. Arabidopsis plants homozygous for a mutation in the ROOT MERISTEMLESS1 (RML1) gene are unable to establish an active postembryonic meristem in the root apex, This mutation abolishes cell division in the root but not in the shoot. We report the molecular cloning of the RML1 gene, which encodes the first enzyme of glutathione (GSH) biosynthesis, gamma-glutamylcysteine synthetase, and which is allelic to CADMIUM SENSITIVE2. The phenotype of the rml1 mutant, which was also evident in the roots of wild-type Arabidopsis and tobacco treated with an inhibitor of GSH biosynthesis, could be relieved by applying GSH to rml1 seedlings. By using a synchronized tobacco cell suspension culture, we showed that the G(1)-to-S phase transition requires an adequate level of GSH, These observations suggest the existence of a GSH-dependent developmental pathway essential for initiation and maintenance of cell division during postembryonic root development.},
  author       = {Vernoux, Teva and Wilson, Robert C and Seeley, Kevin A and Reichheld, Jean-Philippe and Muroy, Sandra and Brown, Spencer and Maughan, Spencer C and Cobbett, Christopher S and Van Montagu, Marc and Inz{\'e}, Dirk and May, Mike and Sung, Zinmay R},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {ACTIVATION,MODULATION,DEFICIENT,EXPRESSION,ORGANIZATION,MERISTEM,BINDING-ACTIVITY,PLANT DEVELOPMENT,GAMMA-GLUTAMYLCYSTEINE SYNTHETASE,ARABIDOPSIS-THALIANA},
  language     = {eng},
  number       = {1},
  pages        = {97--109},
  title        = {The ROOT MERISTEMLESS1/CADMIUM SENSITIVE2 gene defines a glutathione-dependent pathway involved in initiation and maintenance of cell division during postembryonic root development},
  url          = {http://dx.doi.org/10.1105/tpc.12.1.97},
  volume       = {12},
  year         = {2000},
}

Chicago
Vernoux, Teva, Robert C Wilson, Kevin A Seeley, Jean-Philippe Reichheld, Sandra Muroy, Spencer Brown, Spencer C Maughan, et al. 2000. “The ROOT MERISTEMLESS1/CADMIUM SENSITIVE2 Gene Defines a Glutathione-dependent Pathway Involved in Initiation and Maintenance of Cell Division During Postembryonic Root Development.” Plant Cell 12 (1): 97–109.
APA
Vernoux, T., Wilson, R. C., Seeley, K. A., Reichheld, J.-P., Muroy, S., Brown, S., Maughan, S. C., et al. (2000). The ROOT MERISTEMLESS1/CADMIUM SENSITIVE2 gene defines a glutathione-dependent pathway involved in initiation and maintenance of cell division during postembryonic root development. PLANT CELL, 12(1), 97–109.
Vancouver
1.
Vernoux T, Wilson RC, Seeley KA, Reichheld J-P, Muroy S, Brown S, et al. The ROOT MERISTEMLESS1/CADMIUM SENSITIVE2 gene defines a glutathione-dependent pathway involved in initiation and maintenance of cell division during postembryonic root development. PLANT CELL. 2000;12(1):97–109.
MLA
Vernoux, Teva, Robert C Wilson, Kevin A Seeley, et al. “The ROOT MERISTEMLESS1/CADMIUM SENSITIVE2 Gene Defines a Glutathione-dependent Pathway Involved in Initiation and Maintenance of Cell Division During Postembryonic Root Development.” PLANT CELL 12.1 (2000): 97–109. Print.