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The secretory small GTPase Rab27B as a marker for breast cancer progression

An Hendrix UGent, Geert Braems UGent, Marc Bracke UGent, Miguel C Seabra, William A Gahl, Olivier De Wever UGent and Wendy Westbroek (2010) ONCOTARGET. 1(4). p.304-308
abstract
In contemporary oncology practice, an urgent need remains to refine the prognostic assessment of breast cancer. It is still difficult to identify patients with early breast cancer who are likely to benefit from adjuvant chemotherapy. Although invasion of cancer cells is the main prognostic denominator in tumor malignancy, our molecular understanding and diagnosis are often inadequate to cope with this activity. Therefore, deciphering molecular pathways of how tumors invade and metastasize may help in the identification of a useful prognostic marker. We recently discovered that the secretory small GTPase Rab27B, a regulator of vesicle exocytosis, delivers proinvasive signals for increased invasiveness, tumor size, and metastasis of various estrogen receptor (ER)-positive breast cancer cell lines, both in vitro and in vivo. In human breast cancer specimens, the presence of Rab27B protein proved to be associated with a low degree of differentiation and the presence of lymph node metastasis in ER-positive breast cancer.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MELANOCYTES, GRISCELLI-SYNDROME, EXPRESSION, METASTASIS, PROTEINS, GROWTH, CELLS, GENE
journal title
ONCOTARGET
Oncotarget
volume
1
issue
4
pages
304 - 308
Web of Science type
Article
Web of Science id
000293477200010
ISSN
1949-2553
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
1247740
handle
http://hdl.handle.net/1854/LU-1247740
date created
2011-05-30 16:13:49
date last changed
2012-02-29 12:33:56
@article{1247740,
  abstract     = {In contemporary oncology practice, an urgent need remains to refine the prognostic assessment of breast cancer. It is still difficult to identify patients with early breast cancer who are likely to benefit from adjuvant chemotherapy. Although invasion of cancer cells is the main prognostic denominator in tumor malignancy, our molecular understanding and diagnosis are often inadequate to cope with this activity. Therefore, deciphering molecular pathways of how tumors invade and metastasize may help in the identification of a useful prognostic marker. We recently discovered that the secretory small GTPase Rab27B, a regulator of vesicle exocytosis, delivers proinvasive signals for increased invasiveness, tumor size, and metastasis of various estrogen receptor (ER)-positive breast cancer cell lines, both in vitro and in vivo. In human breast cancer specimens, the presence of Rab27B protein proved to be associated with a low degree of differentiation and the presence of lymph node metastasis in ER-positive breast cancer.},
  author       = {Hendrix, An and Braems, Geert and Bracke, Marc and Seabra, Miguel C and Gahl, William A and De Wever, Olivier and Westbroek, Wendy},
  issn         = {1949-2553},
  journal      = {ONCOTARGET},
  keyword      = {MELANOCYTES,GRISCELLI-SYNDROME,EXPRESSION,METASTASIS,PROTEINS,GROWTH,CELLS,GENE},
  language     = {eng},
  number       = {4},
  pages        = {304--308},
  title        = {The secretory small GTPase Rab27B as a marker for breast cancer progression},
  volume       = {1},
  year         = {2010},
}

Chicago
Hendrix, An, Geert Braems, Marc Bracke, Miguel C Seabra, William A Gahl, Olivier De Wever, and Wendy Westbroek. 2010. “The Secretory Small GTPase Rab27B as a Marker for Breast Cancer Progression.” Oncotarget 1 (4): 304–308.
APA
Hendrix, A., Braems, G., Bracke, M., Seabra, M. C., Gahl, W. A., De Wever, O., & Westbroek, W. (2010). The secretory small GTPase Rab27B as a marker for breast cancer progression. ONCOTARGET, 1(4), 304–308.
Vancouver
1.
Hendrix A, Braems G, Bracke M, Seabra MC, Gahl WA, De Wever O, et al. The secretory small GTPase Rab27B as a marker for breast cancer progression. ONCOTARGET. 2010;1(4):304–8.
MLA
Hendrix, An, Geert Braems, Marc Bracke, et al. “The Secretory Small GTPase Rab27B as a Marker for Breast Cancer Progression.” ONCOTARGET 1.4 (2010): 304–308. Print.