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Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells

AS Ribeiro, A Albergaria, B Sousa, AL Correia, Marc Bracke UGent, R Seruca, FC Schmitt and J Paredes (2010) ONCOGENE. 29(3). p.392-402
abstract
Cell-cell adhesion is an elementary process in normal epithelial cellular architecture. Several studies have shown the role mediated by cadherins in this process, besides their role in the maintenance of cell polarity, differentiation and cell growth. However, during tumour progression, these molecules are frequently altered. In breast cancer, tumours that overexpress P-cadherin usually present a high histological grade, show decreased cell polarity and are associated with worse patient survival. However, little is known about how this protein dictates the very aggressive behaviour of these tumours. To achieve this goal, we set up two breast cancer cell models, where P-cadherin expression was differently modulated and analysed in terms of cell invasion, motility and migration. We show that P-cadherin overexpression, in breast cancer cells with wild-type E-cadherin, promotes cell invasion, motility and migration. Moreover, we found that the overexpression of P-cadherin induces the secretion of matrix metalloproteases, specifically MMP-1 and MMP-2, which then lead to P-cadherin ectodomain cleavage. Further, we showed that soluble P-cadherin fragment is able to induce in vitro invasion of breast cancer cells. Overall, our results contribute to elucidate the mechanism underlying the invasive behaviour of P-cadherin expressing breast tumours. Oncogene (2010) 29, 392-402; doi:10.1038/onc.2009.338; published online 9 November 2009
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EXPRESSION, GASTRIC-CANCER, ADHESION, LINES, CARCINOMA, MOTILITY, METASTASIS, PHENOTYPE, P-cadherin, migration, invasion, MMPs, sP-cad, EPITHELIAL-MESENCHYMAL TRANSITION, MATRIX METALLOPROTEINASE-1
journal title
ONCOGENE
Oncogene
volume
29
issue
3
pages
392 - 402
Web of Science type
Article
Web of Science id
000273793200008
JCR category
ONCOLOGY
JCR impact factor
7.414 (2010)
JCR rank
15/181 (2010)
JCR quartile
1 (2010)
ISSN
0950-9232
DOI
10.1038/onc.2009.338
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1247521
handle
http://hdl.handle.net/1854/LU-1247521
date created
2011-05-30 15:03:47
date last changed
2011-06-01 15:51:16
@article{1247521,
  abstract     = {Cell-cell adhesion is an elementary process in normal epithelial cellular architecture. Several studies have shown the role mediated by cadherins in this process, besides their role in the maintenance of cell polarity, differentiation and cell growth. However, during tumour progression, these molecules are frequently altered. In breast cancer, tumours that overexpress P-cadherin usually present a high histological grade, show decreased cell polarity and are associated with worse patient survival. However, little is known about how this protein dictates the very aggressive behaviour of these tumours. To achieve this goal, we set up two breast cancer cell models, where P-cadherin expression was differently modulated and analysed in terms of cell invasion, motility and migration. We show that P-cadherin overexpression, in breast cancer cells with wild-type E-cadherin, promotes cell invasion, motility and migration. Moreover, we found that the overexpression of P-cadherin induces the secretion of matrix metalloproteases, specifically MMP-1 and MMP-2, which then lead to P-cadherin ectodomain cleavage. Further, we showed that soluble P-cadherin fragment is able to induce in vitro invasion of breast cancer cells. Overall, our results contribute to elucidate the mechanism underlying the invasive behaviour of P-cadherin expressing breast tumours. Oncogene (2010) 29, 392-402; doi:10.1038/onc.2009.338; published online 9 November 2009},
  author       = {Ribeiro, AS and Albergaria, A and Sousa, B and Correia, AL and Bracke, Marc and Seruca, R and Schmitt, FC and Paredes, J},
  issn         = {0950-9232},
  journal      = {ONCOGENE},
  keyword      = {EXPRESSION,GASTRIC-CANCER,ADHESION,LINES,CARCINOMA,MOTILITY,METASTASIS,PHENOTYPE,P-cadherin,migration,invasion,MMPs,sP-cad,EPITHELIAL-MESENCHYMAL TRANSITION,MATRIX METALLOPROTEINASE-1},
  language     = {eng},
  number       = {3},
  pages        = {392--402},
  title        = {Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells},
  url          = {http://dx.doi.org/10.1038/onc.2009.338},
  volume       = {29},
  year         = {2010},
}

Chicago
Ribeiro, AS, A Albergaria, B Sousa, AL Correia, Marc Bracke, R Seruca, FC Schmitt, and J Paredes. 2010. “Extracellular Cleavage and Shedding of P-cadherin: a Mechanism Underlying the Invasive Behaviour of Breast Cancer Cells.” Oncogene 29 (3): 392–402.
APA
Ribeiro, A., Albergaria, A., Sousa, B., Correia, A., Bracke, M., Seruca, R., Schmitt, F., et al. (2010). Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells. ONCOGENE, 29(3), 392–402.
Vancouver
1.
Ribeiro A, Albergaria A, Sousa B, Correia A, Bracke M, Seruca R, et al. Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells. ONCOGENE. 2010;29(3):392–402.
MLA
Ribeiro, AS, A Albergaria, B Sousa, et al. “Extracellular Cleavage and Shedding of P-cadherin: a Mechanism Underlying the Invasive Behaviour of Breast Cancer Cells.” ONCOGENE 29.3 (2010): 392–402. Print.