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p63, a story of mice and men

Hans Vanbokhoven, Gerry Melino, Eleonora Candi and Wim Declercq UGent (2011) JOURNAL OF INVESTIGATIVE DERMATOLOGY. 131(6). p.1196-1207
abstract
The transcription factor p63 is essential for the formation of the epidermis and other stratifying epithelia. This is clearly demonstrated by the severe abnormality of p63-deficient mice and by the development of certain types of ectodermal dysplasias in humans as a result of p63 mutations. Investigation of the in vivo functions of p63 is complicated by the occurrence of 10 different splicing isoforms and by its interaction with the other family members, p53 and p73. In vitro and in vivo models have been used to unravel the functions of p63 and its different isoforms, but the results or their interpretation are often contradictory. This review focuses on what mammalian in vivo models and patient studies have taught us in the last 10 years.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HODGKIN ECTODERMAL DYSPLASIA, HAND/SPLIT-FOOT MALFORMATION, PROTECTS MOUSE OOCYTES, HAY-WELLS-SYNDROME, RAPP-HODGKIN, CLEFT-LIP, STEM-CELLS, IKK-ALPHA, EPIDERMAL DEVELOPMENT, LIMB DEVELOPMENT
journal title
JOURNAL OF INVESTIGATIVE DERMATOLOGY
J. Invest. Dermatol.
volume
131
issue
6
pages
1196 - 1207
Web of Science type
Article
Web of Science id
000290616700008
JCR category
DERMATOLOGY
JCR impact factor
6.314 (2011)
JCR rank
1/58 (2011)
JCR quartile
1 (2011)
ISSN
0022-202X
DOI
10.1038/jid.2011.84
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1247105
handle
http://hdl.handle.net/1854/LU-1247105
date created
2011-05-30 13:12:52
date last changed
2012-06-26 14:32:19
@article{1247105,
  abstract     = {The transcription factor p63 is essential for the formation of the epidermis and other stratifying epithelia. This is clearly demonstrated by the severe abnormality of p63-deficient mice and by the development of certain types of ectodermal dysplasias in humans as a result of p63 mutations. Investigation of the in vivo functions of p63 is complicated by the occurrence of 10 different splicing isoforms and by its interaction with the other family members, p53 and p73. In vitro and in vivo models have been used to unravel the functions of p63 and its different isoforms, but the results or their interpretation are often contradictory. This review focuses on what mammalian in vivo models and patient studies have taught us in the last 10 years.},
  author       = {Vanbokhoven, Hans and Melino, Gerry and Candi, Eleonora and Declercq, Wim},
  issn         = {0022-202X},
  journal      = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
  keyword      = {HODGKIN ECTODERMAL DYSPLASIA,HAND/SPLIT-FOOT MALFORMATION,PROTECTS MOUSE OOCYTES,HAY-WELLS-SYNDROME,RAPP-HODGKIN,CLEFT-LIP,STEM-CELLS,IKK-ALPHA,EPIDERMAL DEVELOPMENT,LIMB DEVELOPMENT},
  language     = {eng},
  number       = {6},
  pages        = {1196--1207},
  title        = {p63, a story of mice and men},
  url          = {http://dx.doi.org/10.1038/jid.2011.84},
  volume       = {131},
  year         = {2011},
}

Chicago
Vanbokhoven, Hans, Gerry Melino, Eleonora Candi, and Wim Declercq. 2011. “P63, a Story of Mice and Men.” Journal of Investigative Dermatology 131 (6): 1196–1207.
APA
Vanbokhoven, H., Melino, G., Candi, E., & Declercq, W. (2011). p63, a story of mice and men. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(6), 1196–1207.
Vancouver
1.
Vanbokhoven H, Melino G, Candi E, Declercq W. p63, a story of mice and men. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(6):1196–207.
MLA
Vanbokhoven, Hans, Gerry Melino, Eleonora Candi, et al. “P63, a Story of Mice and Men.” JOURNAL OF INVESTIGATIVE DERMATOLOGY 131.6 (2011): 1196–1207. Print.