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Assessment of neovascular permeability in a pancreatic tumor model using dynamic contrast-enhanced (DCE) MRI with contrast agents of different molecular weights

LOUKE DELRUE UGent, VEERLE CASNEUF UGent, Nancy Van Damme UGent, PETER BLANCKAERT UGent, Marc Peeters UGent, Wim Ceelen UGent and Philippe Duyck UGent (2011) MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 24(4). p.225-232
abstract
Object: We evaluated the relationship of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-derived pharmacokinetic parameters and contrast agents with different molecular weights (MW) in a pancreatic tumor mouse model. Materials and methods: Panc02 tumors were induced in mice at the hind leg. DCE-MRI was performed using Gadolinium (Gd)-based contrast agents with different MW: Gd-DOTA (0.5 kDa), P846 (3.5 kDa), and P792 (6.47 kDa). Quantitative vascular parameters (AUC, K trans, V e, and V p) were calculated according to a modified Tofts two-compartment model. Values for all contrast groups were compared for tumor and control (muscle) tissues. Results: Values for K trans and V e were significantly higher in tumor tissue than in muscle tissue. When comparing contrast agents, lowest absolute K trans values were observed using P792. The relative increase in K trans in tumor tissue compared with normal tissue was highest after the use of P792. In both tumor and normal tissues, K trans decreased with increasing molecular weight of the contrast agent used. Conclusion: It was demonstrated that values for the different DCE-MRI vascular (permeability) parameters are highly dependent on the contrast agent used. Due to their potential to better differentiate tumor from muscle tissue, higher molecular weight contrast agents show promise when evaluating tumors using DCE-MRI.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Gd-DOTA, MRI contrast, DCE-MRI, P846, P792, RODENT PROSTATE TUMORS, KINETIC-PARAMETERS, CANCER, ANGIOGENESIS, RADIOTHERAPY, MICROCIRCULATION, DISTINGUISHES, CARCINOMA, TRACER, MEDIA
journal title
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Magn. Reson. Mat. Phys. Biol. Med.
volume
24
issue
4
pages
225 - 232
Web of Science type
Article
Web of Science id
000295178100004
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.883 (2011)
JCR rank
52/116 (2011)
JCR quartile
2 (2011)
ISSN
0968-5243
DOI
10.1007/s10334-011-0256-9
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1245869
handle
http://hdl.handle.net/1854/LU-1245869
date created
2011-05-27 14:47:42
date last changed
2012-04-25 13:18:31
@article{1245869,
  abstract     = {Object: We evaluated the relationship of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-derived pharmacokinetic parameters and contrast agents with different molecular weights (MW) in a pancreatic tumor mouse model.
Materials and methods: Panc02 tumors were induced in mice at the hind leg. DCE-MRI was performed using Gadolinium (Gd)-based contrast agents with different MW: Gd-DOTA (0.5 kDa), P846 (3.5 kDa), and P792 (6.47 kDa). Quantitative vascular parameters (AUC, K trans, V e, and V p) were calculated according to a modified Tofts two-compartment model. Values for all contrast groups were compared for tumor and control (muscle) tissues.
Results: Values for K trans and V e were significantly higher in tumor tissue than in muscle tissue. When comparing contrast agents, lowest absolute K trans values were observed using P792. The relative increase in K trans in tumor tissue compared with normal tissue was highest after the use of P792. In both tumor and normal tissues, K trans decreased with increasing molecular weight of the contrast agent used.
Conclusion: It was demonstrated that values for the different DCE-MRI vascular (permeability) parameters are highly dependent on the contrast agent used. Due to their potential to better differentiate tumor from muscle tissue, higher molecular weight contrast agents show promise when evaluating tumors using DCE-MRI.},
  author       = {DELRUE, LOUKE and CASNEUF, VEERLE and Van Damme, Nancy and BLANCKAERT, PETER and Peeters, Marc and Ceelen, Wim and Duyck, Philippe},
  issn         = {0968-5243},
  journal      = {MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE},
  keyword      = {Gd-DOTA,MRI contrast,DCE-MRI,P846,P792,RODENT PROSTATE TUMORS,KINETIC-PARAMETERS,CANCER,ANGIOGENESIS,RADIOTHERAPY,MICROCIRCULATION,DISTINGUISHES,CARCINOMA,TRACER,MEDIA},
  language     = {eng},
  number       = {4},
  pages        = {225--232},
  title        = {Assessment of neovascular permeability in a pancreatic tumor model using dynamic contrast-enhanced (DCE) MRI with contrast agents of different molecular weights},
  url          = {http://dx.doi.org/10.1007/s10334-011-0256-9},
  volume       = {24},
  year         = {2011},
}

Chicago
Delrue, Louke, VEERLE CASNEUF, Nancy Van Damme, PETER BLANCKAERT, Marc Peeters, Wim Ceelen, and Philippe Duyck. 2011. “Assessment of Neovascular Permeability in a Pancreatic Tumor Model Using Dynamic Contrast-enhanced (DCE) MRI with Contrast Agents of Different Molecular Weights.” Magnetic Resonance Materials in Physics Biology and Medicine 24 (4): 225–232.
APA
Delrue, L., CASNEUF, V., Van Damme, N., BLANCKAERT, P., Peeters, M., Ceelen, W., & Duyck, P. (2011). Assessment of neovascular permeability in a pancreatic tumor model using dynamic contrast-enhanced (DCE) MRI with contrast agents of different molecular weights. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 24(4), 225–232.
Vancouver
1.
Delrue L, CASNEUF V, Van Damme N, BLANCKAERT P, Peeters M, Ceelen W, et al. Assessment of neovascular permeability in a pancreatic tumor model using dynamic contrast-enhanced (DCE) MRI with contrast agents of different molecular weights. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 2011;24(4):225–32.
MLA
Delrue, Louke, VEERLE CASNEUF, Nancy Van Damme, et al. “Assessment of Neovascular Permeability in a Pancreatic Tumor Model Using Dynamic Contrast-enhanced (DCE) MRI with Contrast Agents of Different Molecular Weights.” MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 24.4 (2011): 225–232. Print.