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Regulation of vascular tone by adipocytes

Nele Maenhaut UGent and Johan Van de Voorde UGent (2011) BMC MEDICINE. 9(25).
abstract
Recent studies have shown that adipose tissue is an active endocrine and paracrine organ secreting several mediators called adipokines. Adipokines include hormones, inflammatory cytokines and other proteins. In obesity, adipose tissue becomes dysfunctional, resulting in an overproduction of proinflammatory adipokines and a lower production of anti-inflammatory adipokines. The pathological accumulation of dysfunctional adipose tissue that characterizes obesity is a major risk factor for many other diseases, including type 2 diabetes, cardiovascular disease and hypertension. Multiple physiological roles have been assigned to adipokines, including the regulation of vascular tone. For example, the unidentified adipocyte-derived relaxing factor (ADRF) released from adipose tissue has been shown to relax arteries. Besides ADRF, other adipokines such as adiponectin, omentin and visfatin are vasorelaxants. On the other hand, angiotensin II and resistin are vasoconstrictors released by adipocytes. Reactive oxygen species, leptin, tumour necrosis factor a, interleukin-6 and apelin share both vasorelaxing and constricting properties. Dysregulated synthesis of the vasoactive and proinflammatory adipokines may underlie the compromised vascular reactivity in obesity and obesity-related disorders.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
PERIVASCULAR ADIPOSE-TISSUE, CARDIOVASCULAR-DISEASE, TUMOR-NECROSIS-FACTOR, ENDOTHELIAL NITRIC-OXIDE, BLOOD-PRESSURE REGULATION, SMOOTH-MUSCLE-CELLS, HYDROGEN-PEROXIDE, ANGIOTENSIN-II, INSULIN-RESISTANCE, TNF-ALPHA
journal title
BMC MEDICINE
BMC Med.
volume
9
issue
25
pages
12 pages
Web of Science type
Review
Web of Science id
000290566900001
JCR category
MEDICINE, GENERAL & INTERNAL
JCR impact factor
6.035 (2011)
JCR rank
9/153 (2011)
JCR quartile
1 (2011)
ISSN
1741-7015
DOI
10.1186/1741-7015-9-25
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1245143
handle
http://hdl.handle.net/1854/LU-1245143
date created
2011-05-27 10:12:34
date last changed
2016-12-19 15:44:47
@article{1245143,
  abstract     = {Recent studies have shown that adipose tissue is an active endocrine and paracrine organ secreting several mediators called adipokines. Adipokines include hormones, inflammatory cytokines and other proteins. In obesity, adipose tissue becomes dysfunctional, resulting in an overproduction of proinflammatory adipokines and a lower production of anti-inflammatory adipokines. The pathological accumulation of dysfunctional adipose tissue that characterizes obesity is a major risk factor for many other diseases, including type 2 diabetes, cardiovascular disease and hypertension. Multiple physiological roles have been assigned to adipokines, including the regulation of vascular tone. For example, the unidentified adipocyte-derived relaxing factor (ADRF) released from adipose tissue has been shown to relax arteries. Besides ADRF, other adipokines such as adiponectin, omentin and visfatin are vasorelaxants. On the other hand, angiotensin II and resistin are vasoconstrictors released by adipocytes. Reactive oxygen species, leptin, tumour necrosis factor a, interleukin-6 and apelin share both vasorelaxing and constricting properties. Dysregulated synthesis of the vasoactive and proinflammatory adipokines may underlie the compromised vascular reactivity in obesity and obesity-related disorders.},
  author       = {Maenhaut, Nele and Van de Voorde, Johan},
  issn         = {1741-7015},
  journal      = {BMC MEDICINE},
  keyword      = {PERIVASCULAR ADIPOSE-TISSUE,CARDIOVASCULAR-DISEASE,TUMOR-NECROSIS-FACTOR,ENDOTHELIAL NITRIC-OXIDE,BLOOD-PRESSURE REGULATION,SMOOTH-MUSCLE-CELLS,HYDROGEN-PEROXIDE,ANGIOTENSIN-II,INSULIN-RESISTANCE,TNF-ALPHA},
  language     = {eng},
  number       = {25},
  pages        = {12},
  title        = {Regulation of vascular tone by adipocytes},
  url          = {http://dx.doi.org/10.1186/1741-7015-9-25},
  volume       = {9},
  year         = {2011},
}

Chicago
Maenhaut, Nele, and Johan Van de Voorde. 2011. “Regulation of Vascular Tone by Adipocytes.” Bmc Medicine 9 (25).
APA
Maenhaut, N., & Van de Voorde, J. (2011). Regulation of vascular tone by adipocytes. BMC MEDICINE, 9(25).
Vancouver
1.
Maenhaut N, Van de Voorde J. Regulation of vascular tone by adipocytes. BMC MEDICINE. 2011;9(25).
MLA
Maenhaut, Nele, and Johan Van de Voorde. “Regulation of Vascular Tone by Adipocytes.” BMC MEDICINE 9.25 (2011): n. pag. Print.