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Ecotoxicity and uptake of polymer coated gold nanoparticles

Karen Van Hoecke UGent, Karel De Schamphelaere UGent, Zulqurnain Ali, Feng Zhang, Andreas Elsaesser, Pilar Rivera-Gil, Wolfgang Parak, Guy Smagghe UGent, Vyvyan Howard and Colin Janssen UGent (2013) NANOTOXICOLOGY. 7(1). p.37-47
abstract
Bioconjugated gold nanoparticles (NPs) are a promising tool for pharmaceutical applications. However, the ecotoxicity of these types of NPs has hardly been studied . We investigated the ecotoxicity and uptake of 4-5 nm Au NPs to which two types of polymer coatings were attached. One coating was an amphiphilic polymer only and the other an amphiphilic coating to which 10 kDa polyethylene glycol (PEG) chains were attached. In both 72 h algal growth inhibition tests with the alga Pseudokirchneriella subcapitata and in 24 h resazurin cytotoxicity tests with the rainbow trout gill cell line RTGill-W1 the pegylated Au NPs were found less toxic compared to the amphiphilic coated particles. No uptake or direct interaction between particles and algal cells was observed. However, uptake/adsorption in fish gill cells reached up to >10^6 particles/cell after 1 h and particles were eliminated for ≥ 96 % after 24 h depuration. Both particle types were found within membrane enclosed vesicles in the cytoplasm of RTgill-W1 cells.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
RTGill-W1, nanoparticles, algae, surface chemistry, Environmental toxicology, COLLOIDAL NANOPARTICLES, DAPHNIA-MAGNA, SIZE, TOXICITY, WATER, CYTOTOXICITY, CELLS, NANOMATERIALS, EXPOSURE, EXCHANGE
journal title
NANOTOXICOLOGY
Nanotoxicology
volume
7
issue
1
pages
37 - 47
Web of Science type
Article
Web of Science id
000313278700005
JCR category
TOXICOLOGY
JCR impact factor
7.336 (2013)
JCR rank
2/87 (2013)
JCR quartile
1 (2013)
ISSN
1743-5390
DOI
10.3109/17435390.2011.626566
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1243848
handle
http://hdl.handle.net/1854/LU-1243848
date created
2011-05-26 10:26:32
date last changed
2013-05-22 13:46:18
@article{1243848,
  abstract     = {Bioconjugated gold nanoparticles (NPs) are a promising tool for pharmaceutical applications. However, the ecotoxicity of these types of NPs has hardly been studied . We investigated the ecotoxicity and uptake of 4-5 nm Au NPs to which two types of polymer coatings were attached. One coating was an amphiphilic polymer only and the other an amphiphilic coating to which 10 kDa polyethylene glycol (PEG) chains were attached. In both 72 h algal growth inhibition tests with the alga Pseudokirchneriella subcapitata and in 24 h resazurin cytotoxicity tests with the rainbow trout gill cell line RTGill-W1 the pegylated Au NPs were found less toxic compared to the amphiphilic coated particles. No uptake or direct interaction between particles and algal cells was observed. However, uptake/adsorption in fish gill cells reached up to {\textrangle}10\^{ }6 particles/cell after 1 h and particles were eliminated for \ensuremath{\geq} 96 \% after 24 h depuration. Both particle types were found within membrane enclosed vesicles in the cytoplasm of RTgill-W1 cells.},
  author       = {Van Hoecke, Karen and De Schamphelaere, Karel and Ali, Zulqurnain and Zhang, Feng and Elsaesser, Andreas and Rivera-Gil, Pilar and Parak, Wolfgang and Smagghe, Guy and Howard, Vyvyan and Janssen, Colin},
  issn         = {1743-5390},
  journal      = {NANOTOXICOLOGY},
  keyword      = {RTGill-W1,nanoparticles,algae,surface chemistry,Environmental toxicology,COLLOIDAL NANOPARTICLES,DAPHNIA-MAGNA,SIZE,TOXICITY,WATER,CYTOTOXICITY,CELLS,NANOMATERIALS,EXPOSURE,EXCHANGE},
  language     = {eng},
  number       = {1},
  pages        = {37--47},
  title        = {Ecotoxicity and uptake of polymer coated gold nanoparticles},
  url          = {http://dx.doi.org/10.3109/17435390.2011.626566},
  volume       = {7},
  year         = {2013},
}

Chicago
Van Hoecke, Karen, Karel De Schamphelaere, Zulqurnain Ali, Feng Zhang, Andreas Elsaesser, Pilar Rivera-Gil, Wolfgang Parak, Guy Smagghe, Vyvyan Howard, and Colin Janssen. 2013. “Ecotoxicity and Uptake of Polymer Coated Gold Nanoparticles.” Nanotoxicology 7 (1): 37–47.
APA
Van Hoecke, K., De Schamphelaere, K., Ali, Z., Zhang, F., Elsaesser, A., Rivera-Gil, P., Parak, W., et al. (2013). Ecotoxicity and uptake of polymer coated gold nanoparticles. NANOTOXICOLOGY, 7(1), 37–47.
Vancouver
1.
Van Hoecke K, De Schamphelaere K, Ali Z, Zhang F, Elsaesser A, Rivera-Gil P, et al. Ecotoxicity and uptake of polymer coated gold nanoparticles. NANOTOXICOLOGY. 2013;7(1):37–47.
MLA
Van Hoecke, Karen, Karel De Schamphelaere, Zulqurnain Ali, et al. “Ecotoxicity and Uptake of Polymer Coated Gold Nanoparticles.” NANOTOXICOLOGY 7.1 (2013): 37–47. Print.