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Clinical and immunological determinants of severe/refractory asthma (SRA): association with Staphylococcal superantigen-specific IgE antibodies

ML Kowalski, M Cieslak, Claudina Perez Novo UGent, JS Makowska and Claus Bachert UGent (2011) ALLERGY. 66(1). p.32-38
abstract
Demographic and immunological determinants of severe refractory asthma (SRA) are not well characterized. Because Staphylococcus aureus enterotoxins with superantigenic activity have been associated with upper and lower airway inflammation, we aimed to evaluate the association of sensitization to Staphylococcal enterotoxins with asthma severity and various asthma phenotypes. Methods: The study included 109 patients with SRA diagnosed according to the American Thoracic Society Workshop 2000, and 101 patients with nonsevere asthma, followed for at least 12 months. Specific IgE to Staphylococcus enterotoxins and total IgE and eosinophil cationic protein concentrations were measured in serum with immunoassays. Findings: A significant risk for severe asthma was associated with female gender [Odds Ratio (OR) = 2.04], history of wheezing in childhood (OR = 2.47), presence of hypersensitivity to aspirin (OR = 1.96) and with body mass index (OR = 3.08). The mean level of enterotoxin-specific IgE was 3-fold higher in patients with severe asthma when compared to patients with nonsevere asthma (P = 0.01). Serum-specific IgE to enterotoxins was significantly associated with low respiratory function parameters (FEV1, FEV1/FVC and MEF 25/75) and increased airway reversibility in response to albuterol. The presence of specific IgE to enterotoxin carried a significant risk for patients to have serum total IgE level above 100 kU/l (OR = 7.84). Interpretation: Specific immunological response to enterotoxins is associated with clinical and immunological parameters of asthma severity, suggesting a role for Staphylococcal enterotoxins in the asthma pathogenesis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
TO-TREAT ASTHMA, ASPIRIN-INTOLERANT ASTHMA, Staphylococcal enterotoxins, severe asthma, refractory asthma, IgE, aspirin sensitivity, OMALIZUMAB, PREVALENCE, SERUM, RESEARCH-PROGRAM, IMMUNOGLOBULIN-E, ALLERGIC RHINITIS, AUREUS ENTEROTOXINS, NASAL POLYPS
journal title
ALLERGY
Allergy
volume
66
issue
1
pages
32 - 38
Web of Science type
Article
Web of Science id
000284960900004
JCR category
ALLERGY
JCR impact factor
6.271 (2011)
JCR rank
2/23 (2011)
JCR quartile
1 (2011)
ISSN
0105-4538
DOI
10.1111/j.1398-9995.2010.02379.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1242825
handle
http://hdl.handle.net/1854/LU-1242825
date created
2011-05-25 16:37:48
date last changed
2011-06-01 14:18:01
@article{1242825,
  abstract     = {Demographic and immunological determinants of severe refractory asthma (SRA) are not well characterized. Because Staphylococcus aureus enterotoxins with superantigenic activity have been associated with upper and lower airway inflammation, we aimed to evaluate the association of sensitization to Staphylococcal enterotoxins with asthma severity and various asthma phenotypes. Methods: The study included 109 patients with SRA diagnosed according to the American Thoracic Society Workshop 2000, and 101 patients with nonsevere asthma, followed for at least 12 months. Specific IgE to Staphylococcus enterotoxins and total IgE and eosinophil cationic protein concentrations were measured in serum with immunoassays. Findings: A significant risk for severe asthma was associated with female gender [Odds Ratio (OR) = 2.04], history of wheezing in childhood (OR = 2.47), presence of hypersensitivity to aspirin (OR = 1.96) and with body mass index (OR = 3.08). The mean level of enterotoxin-specific IgE was 3-fold higher in patients with severe asthma when compared to patients with nonsevere asthma (P = 0.01). Serum-specific IgE to enterotoxins was significantly associated with low respiratory function parameters (FEV1, FEV1/FVC and MEF 25/75) and increased airway reversibility in response to albuterol. The presence of specific IgE to enterotoxin carried a significant risk for patients to have serum total IgE level above 100 kU/l (OR = 7.84). Interpretation: Specific immunological response to enterotoxins is associated with clinical and immunological parameters of asthma severity, suggesting a role for Staphylococcal enterotoxins in the asthma pathogenesis.},
  author       = {Kowalski, ML and Cieslak, M and Perez Novo, Claudina and Makowska, JS and Bachert, Claus},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keyword      = {TO-TREAT ASTHMA,ASPIRIN-INTOLERANT ASTHMA,Staphylococcal enterotoxins,severe asthma,refractory asthma,IgE,aspirin sensitivity,OMALIZUMAB,PREVALENCE,SERUM,RESEARCH-PROGRAM,IMMUNOGLOBULIN-E,ALLERGIC RHINITIS,AUREUS ENTEROTOXINS,NASAL POLYPS},
  language     = {eng},
  number       = {1},
  pages        = {32--38},
  title        = {Clinical and immunological determinants of severe/refractory asthma (SRA): association with Staphylococcal superantigen-specific IgE antibodies},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2010.02379.x},
  volume       = {66},
  year         = {2011},
}

Chicago
Kowalski, ML, M Cieslak, Claudina Perez Novo, JS Makowska, and Claus Bachert. 2011. “Clinical and Immunological Determinants of Severe/refractory Asthma (SRA): Association with Staphylococcal Superantigen-specific IgE Antibodies.” Allergy 66 (1): 32–38.
APA
Kowalski, M., Cieslak, M., Perez Novo, C., Makowska, J., & Bachert, C. (2011). Clinical and immunological determinants of severe/refractory asthma (SRA): association with Staphylococcal superantigen-specific IgE antibodies. ALLERGY, 66(1), 32–38.
Vancouver
1.
Kowalski M, Cieslak M, Perez Novo C, Makowska J, Bachert C. Clinical and immunological determinants of severe/refractory asthma (SRA): association with Staphylococcal superantigen-specific IgE antibodies. ALLERGY. 2011;66(1):32–8.
MLA
Kowalski, ML, M Cieslak, Claudina Perez Novo, et al. “Clinical and Immunological Determinants of Severe/refractory Asthma (SRA): Association with Staphylococcal Superantigen-specific IgE Antibodies.” ALLERGY 66.1 (2011): 32–38. Print.