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PET with 18F-labelled choline-based tracers for tumour imaging: a review of the literature

Koen Mertens, Dominique Slaets, Bieke Lambert UGent, Marjan Acou UGent, Filip De Vos UGent and Ingeborg Goethals UGent (2010) EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 37(11). p.2188-2193
abstract
To give an up-to-date overview of the potential clinical utility of F-18-labelled choline derivatives for tumour imaging with positron emission tomography. A PubMed search for F-18-labelled choline analogues was performed. Review articles and reference lists were used to supplement the search findings. F-18-labelled choline analogues have been investigated as oncological PET probes for many types of cancer on the basis of enhanced cell proliferation. To date, studies have focused on the evaluation of prostate cancer. Available studies have provided preliminary results for detecting local and metastatic disease. Experience with F-18-fluorocholine PET in other tumour types, including brain and liver tumours, is still limited. In the brain, excellent discrimination between tumour and normal tissue can be achieved due to the low physiological uptake of F-18-fluorocholine. In the liver, in which there is a moderate to high degree of physiological uptake in normal tissue, malignancy discrimination may be more challenging. PET/CT with F-18-fluorocholine can be used to detect (recurrent) local prostate cancer, but seems to have limited value for T (tumour) and N (nodal) staging. In patients presenting with recurrent biochemical prostate cancer, it is a suitable single-step examination with the ability to exclude distant metastases when local salvage treatment is intended. In the brain, high-grade gliomas, metastases and benign lesions can be distinguished on the basis of F-18-fluorocholine uptake. Moreover, PET imaging is able to differentiate between radiation-induced injury and tumour recurrence. In the liver, F-18-fluorocholine PET/CT seems promising for the detection of hepatocellular carcinoma.
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author
organization
alternative title
PET with F-18-labelled choline-based tracers for tumour imaging : a review of the literature
year
type
journalArticle (review)
publication status
published
subject
keyword
HEPATOCELLULAR-CARCINOMA, FDG-PET, F-18-CHOLINE PET/CT, F-18-FLUOROCHOLINE PET, DIFFERENTIAL-DIAGNOSIS, F-18-FDG PET, C-11-CHOLINE PET, PROSTATE-CANCER, MAGNETIC-RESONANCE-SPECTROSCOPY, POSITRON-EMISSION-TOMOGRAPHY, Choline, PET/CT, F-18, Oncology
journal title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Eur. J. Nucl. Med. Mol. Imaging
volume
37
issue
11
pages
2188 - 2193
Web of Science type
Review
Web of Science id
000282424400020
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
5.036 (2010)
JCR rank
6/111 (2010)
JCR quartile
1 (2010)
ISSN
1619-7070
DOI
10.1007/s00259-010-1496-z
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1242283
handle
http://hdl.handle.net/1854/LU-1242283
date created
2011-05-25 15:17:47
date last changed
2016-12-19 15:44:47
@article{1242283,
  abstract     = {To give an up-to-date overview of the potential clinical utility of F-18-labelled choline derivatives for tumour imaging with positron emission tomography.
A PubMed search for F-18-labelled choline analogues was performed. Review articles and reference lists were used to supplement the search findings.
F-18-labelled choline analogues have been investigated as oncological PET probes for many types of cancer on the basis of enhanced cell proliferation. To date, studies have focused on the evaluation of prostate cancer. Available studies have provided preliminary results for detecting local and metastatic disease. Experience with F-18-fluorocholine PET in other tumour types, including brain and liver tumours, is still limited. In the brain, excellent discrimination between tumour and normal tissue can be achieved due to the low physiological uptake of F-18-fluorocholine. In the liver, in which there is a moderate to high degree of physiological uptake in normal tissue, malignancy discrimination may be more challenging.
PET/CT with F-18-fluorocholine can be used to detect (recurrent) local prostate cancer, but seems to have limited value for T (tumour) and N (nodal) staging. In patients presenting with recurrent biochemical prostate cancer, it is a suitable single-step examination with the ability to exclude distant metastases when local salvage treatment is intended. In the brain, high-grade gliomas, metastases and benign lesions can be distinguished on the basis of F-18-fluorocholine uptake. Moreover, PET imaging is able to differentiate between radiation-induced injury and tumour recurrence. In the liver, F-18-fluorocholine PET/CT seems promising for the detection of hepatocellular carcinoma.},
  author       = {Mertens, Koen and Slaets, Dominique and Lambert, Bieke and Acou, Marjan and De Vos, Filip and Goethals, Ingeborg},
  issn         = {1619-7070},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  keyword      = {HEPATOCELLULAR-CARCINOMA,FDG-PET,F-18-CHOLINE PET/CT,F-18-FLUOROCHOLINE PET,DIFFERENTIAL-DIAGNOSIS,F-18-FDG PET,C-11-CHOLINE PET,PROSTATE-CANCER,MAGNETIC-RESONANCE-SPECTROSCOPY,POSITRON-EMISSION-TOMOGRAPHY,Choline,PET/CT,F-18,Oncology},
  language     = {eng},
  number       = {11},
  pages        = {2188--2193},
  title        = {PET with 18F-labelled choline-based tracers for tumour imaging: a review of the literature},
  url          = {http://dx.doi.org/10.1007/s00259-010-1496-z},
  volume       = {37},
  year         = {2010},
}

Chicago
Mertens, Koen, Dominique Slaets, Bieke Lambert, Marjan Acou, Filip De Vos, and Ingeborg Goethals. 2010. “PET with 18F-labelled Choline-based Tracers for Tumour Imaging: a Review of the Literature.” European Journal of Nuclear Medicine and Molecular Imaging 37 (11): 2188–2193.
APA
Mertens, Koen, Slaets, D., Lambert, B., Acou, M., De Vos, F., & Goethals, I. (2010). PET with 18F-labelled choline-based tracers for tumour imaging: a review of the literature. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 37(11), 2188–2193.
Vancouver
1.
Mertens K, Slaets D, Lambert B, Acou M, De Vos F, Goethals I. PET with 18F-labelled choline-based tracers for tumour imaging: a review of the literature. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37(11):2188–93.
MLA
Mertens, Koen, Dominique Slaets, Bieke Lambert, et al. “PET with 18F-labelled Choline-based Tracers for Tumour Imaging: a Review of the Literature.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 37.11 (2010): 2188–2193. Print.