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Discriminating cancer from noncancer tissue in the prostate by 3-dimensional proton magnetic resonance spectroscopic imaging a prospective multicenter validation study

(2011) INVESTIGATIVE RADIOLOGY. 46(1). p.25-33
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Abstract
Objectives: A prospective multicenter validation of the ability of H-1 magnetic resonance spectroscopic imaging (MRSI) to distinguish cancer from noncancer tissues throughout the prostate with histopathology of the resected organ as the standard of reference. Materials and Methods: Institutional review board approval was obtained for all centers and all participating patients and volunteers provided written informed consent. Ninety-nine patients and 10 age-matched volunteers from 8 participating centers underwent magnetic resonance imaging and 3-dimensional MRSI with an endorectal coil at 1.5 T. Selected MRSI voxels were assigned to the peripheral zone (PZ), the central gland (CG), the periurethral area, and cancer tissue. Signal ratios of choline + creatine to citrate (CC/C) in spectra of these voxels were automatically calculated. Receiver operating characteristic curves were constructed to assess the accuracy by which this ratio can discriminate cancer from noncancer tissue. Results: A total of 70% of voxels in noncancer tissue and 90% of voxels in cancer tissue passed the quality check of the automatically fitted spectra. The median CC/C was significantly different between any noncancer and cancer tissue (P < 0.0001), but not between the different contributing centers. CC/C increased with cancer focus size (P = 0.0008) and certainty of voxel mapping to histopathologic cancer site (P < 0.0001). The area under the receiver operating characteristic curve for discriminating voxels of cancer tissue from noncancer tissue was 0.88 (confidence interval: 0.84-0.92) in the PZ and 0.76 (confidence interval: 0.71-0.81) in the CG. Conclusions: In patients with prostate cancer, recruited from different institutions, 3-dimensional MRSI is demonstrated to be a robust and quantitative technique, producing significantly different CC/C values for cancer compared with noncancer tissue for both the CG and the PZ.
Keywords
TUMOR, MRSI, ENDORECTAL MR, LOCALIZATION, RADIATION-THERAPY, RADICAL PROSTATECTOMY, PERIPHERAL ZONE, PREDICTION, ACCURACY, EXPERIENCE, validation, prostate cancer, spectroscopic imaging

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Citation

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Chicago
Scheenen, Tom WJ, Jurgen Fütterer, Elisabeth Weiland, Paul van Hecke, Marc Lemort, Christian Zechmann, Heinz-Peter Schlemmer, et al. 2011. “Discriminating Cancer from Noncancer Tissue in the Prostate by 3-dimensional Proton Magnetic Resonance Spectroscopic Imaging a Prospective Multicenter Validation Study.” Investigative Radiology 46 (1): 25–33.
APA
Scheenen, T. W., Fütterer, J., Weiland, E., van Hecke, P., Lemort, M., Zechmann, C., Schlemmer, H.-P., et al. (2011). Discriminating cancer from noncancer tissue in the prostate by 3-dimensional proton magnetic resonance spectroscopic imaging a prospective multicenter validation study. INVESTIGATIVE RADIOLOGY, 46(1), 25–33. Presented at the 17th Annual meeting of the International Society of Magnetic Resonance in Medicine.
Vancouver
1.
Scheenen TW, Fütterer J, Weiland E, van Hecke P, Lemort M, Zechmann C, et al. Discriminating cancer from noncancer tissue in the prostate by 3-dimensional proton magnetic resonance spectroscopic imaging a prospective multicenter validation study. INVESTIGATIVE RADIOLOGY. 2011;46(1):25–33.
MLA
Scheenen, Tom WJ, Jurgen Fütterer, Elisabeth Weiland, et al. “Discriminating Cancer from Noncancer Tissue in the Prostate by 3-dimensional Proton Magnetic Resonance Spectroscopic Imaging a Prospective Multicenter Validation Study.” INVESTIGATIVE RADIOLOGY 46.1 (2011): 25–33. Print.
@article{1242126,
  abstract     = {Objectives: A prospective multicenter validation of the ability of H-1 magnetic resonance spectroscopic imaging (MRSI) to distinguish cancer from noncancer tissues throughout the prostate with histopathology of the resected organ as the standard of reference. Materials and Methods: Institutional review board approval was obtained for all centers and all participating patients and volunteers provided written informed consent. Ninety-nine patients and 10 age-matched volunteers from 8 participating centers underwent magnetic resonance imaging and 3-dimensional MRSI with an endorectal coil at 1.5 T. Selected MRSI voxels were assigned to the peripheral zone (PZ), the central gland (CG), the periurethral area, and cancer tissue. Signal ratios of choline + creatine to citrate (CC/C) in spectra of these voxels were automatically calculated. Receiver operating characteristic curves were constructed to assess the accuracy by which this ratio can discriminate cancer from noncancer tissue. Results: A total of 70\% of voxels in noncancer tissue and 90\% of voxels in cancer tissue passed the quality check of the automatically fitted spectra. The median CC/C was significantly different between any noncancer and cancer tissue (P {\textlangle} 0.0001), but not between the different contributing centers. CC/C increased with cancer focus size (P = 0.0008) and certainty of voxel mapping to histopathologic cancer site (P {\textlangle} 0.0001). The area under the receiver operating characteristic curve for discriminating voxels of cancer tissue from noncancer tissue was 0.88 (confidence interval: 0.84-0.92) in the PZ and 0.76 (confidence interval: 0.71-0.81) in the CG. Conclusions: In patients with prostate cancer, recruited from different institutions, 3-dimensional MRSI is demonstrated to be a robust and quantitative technique, producing significantly different CC/C values for cancer compared with noncancer tissue for both the CG and the PZ.},
  author       = {Scheenen, Tom WJ and F{\"u}tterer, Jurgen and Weiland, Elisabeth and van Hecke, Paul and Lemort, Marc and Zechmann, Christian and Schlemmer, Heinz-Peter and Broome, Dale and Villeirs, Geert and Lu, Jianping and Barentsz, Jelle and Roell, Stefan and Heerschap, Arend},
  issn         = {0020-9996},
  journal      = {INVESTIGATIVE RADIOLOGY},
  keyword      = {TUMOR,MRSI,ENDORECTAL MR,LOCALIZATION,RADIATION-THERAPY,RADICAL PROSTATECTOMY,PERIPHERAL ZONE,PREDICTION,ACCURACY,EXPERIENCE,validation,prostate cancer,spectroscopic imaging},
  language     = {eng},
  location     = {Honolulu, HI, USA},
  number       = {1},
  pages        = {25--33},
  title        = {Discriminating cancer from noncancer tissue in the prostate by 3-dimensional proton magnetic resonance spectroscopic imaging a prospective multicenter validation study},
  url          = {http://dx.doi.org/10.1097/RLI.0b013e3181f54081},
  volume       = {46},
  year         = {2011},
}

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