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First evidence of high knockdown resistance frequency in anopheles arabiensis (diptera: Culicidae) from Ethiopia

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Abstract
The status of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia. Among 240 mosquito samples from 15 villages of southwestern Ethiopia that were screened by allele-specific polymerase chain reaction for kdr mutations, the West African kdr mutation (L1014F) was detected in almost all specimens (98.5%), whereas the East African kdr mutation (L1014S) was absent. Moreover, the mortality of An. gambiae s.l. to diagnostic dosages of 4% DDT, 0.75% permethrin, and 0.05% deltamethrin from bioassay results was 1.0%, 18.1%, and 82.2%, respectively. We report here the highest kdr allele frequency ever observed in An. arabiensis and its implications in malaria vector control in Ethiopia are discussed.
Keywords
KDR MUTATION, INSECTICIDE RESISTANCE, SODIUM-CHANNEL GENE, GAMBIAE COMPLEX, PYRETHROID INSECTICIDES, BURKINA-FASO, TREATED NETS, COTE-DIVOIRE, POPULATIONS, MALARIA

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Citation

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Chicago
Gebre, Delenasaw Yewhalaw, Wim Van Bortel, Leen Denis, Marc Coosemans, Luc Duchateau, and Niko Speybroeck. 2010. “First Evidence of High Knockdown Resistance Frequency in Anopheles Arabiensis (diptera: Culicidae) from Ethiopia.” American Journal of Tropical Medicine and Hygiene 83 (1): 122–125.
APA
Gebre, D. Y., Van Bortel, W., Denis, L., Coosemans, M., Duchateau, L., & Speybroeck, N. (2010). First evidence of high knockdown resistance frequency in anopheles arabiensis (diptera: Culicidae) from Ethiopia. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 83(1), 122–125.
Vancouver
1.
Gebre DY, Van Bortel W, Denis L, Coosemans M, Duchateau L, Speybroeck N. First evidence of high knockdown resistance frequency in anopheles arabiensis (diptera: Culicidae) from Ethiopia. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2010;83(1):122–5.
MLA
Gebre, Delenasaw Yewhalaw et al. “First Evidence of High Knockdown Resistance Frequency in Anopheles Arabiensis (diptera: Culicidae) from Ethiopia.” AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 83.1 (2010): 122–125. Print.
@article{1235172,
  abstract     = {The status of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia. Among 240 mosquito samples from 15 villages of southwestern Ethiopia that were screened by allele-specific polymerase chain reaction for kdr mutations, the West African kdr mutation (L1014F) was detected in almost all specimens (98.5%), whereas the East African kdr mutation (L1014S) was absent. Moreover, the mortality of An. gambiae s.l. to diagnostic dosages of 4% DDT, 0.75% permethrin, and 0.05% deltamethrin from bioassay results was 1.0%, 18.1%, and 82.2%, respectively. We report here the highest kdr allele frequency ever observed in An. arabiensis and its implications in malaria vector control in Ethiopia are discussed.},
  author       = {Gebre, Delenasaw Yewhalaw and Van Bortel, Wim and Denis, Leen and Coosemans, Marc and Duchateau, Luc and Speybroeck, Niko},
  issn         = {0002-9637},
  journal      = {AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE},
  keywords     = {KDR MUTATION,INSECTICIDE RESISTANCE,SODIUM-CHANNEL GENE,GAMBIAE COMPLEX,PYRETHROID INSECTICIDES,BURKINA-FASO,TREATED NETS,COTE-DIVOIRE,POPULATIONS,MALARIA},
  language     = {eng},
  number       = {1},
  pages        = {122--125},
  title        = {First evidence of high knockdown resistance frequency in anopheles arabiensis (diptera: Culicidae) from Ethiopia},
  url          = {http://dx.doi.org/10.4269/ajtmh.2010.09-0738},
  volume       = {83},
  year         = {2010},
}

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