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Cardiovascular effects of epidural administration of methadone, ropivacaine 0.75% and their combination in isoflurane anaesthetized dogs

Tim Bosmans (UGent) , Stijn Schauvliege (UGent) , Frank Gasthuys (UGent) , Luc Duchateau (UGent) , Miguel Gozalo Marcilla (UGent) , Caroline Gadeyne (UGent) and Ingeborgh Polis (UGent)
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Abstract
Objective To compare the cardiovascular effects of four epidural treatments in isoflurane anaesthetised dogs. Study design Prospective, randomized. experimental study. Animals Six female, neutered Beagle dogs (13.3 +/- 1.0 kg), aged 3.6 +/- 0.1 years. Methods Anaesthesia was induced with propofol (8.3 +/- 1.1 mg kg(-1)) and maintained with isoflurane in a mixture of oxygen and air [inspiratory fraction of oxygen (FiO(2)) = 40%], using intermittent positive pressure ventilation. Using a cross-over model, NaCl 0.9% (P); methadone 1% 0.1 mg kg(-1) (M); ropivacaine 0.75% 1.65 mg kg(-1) (R) or methadone 1% 0.1 mg kg(-1) + ropivacaine 0.75% 1.65 mg kg(-1) (RM) in equal volumes (0.23 mL kg(-1)) using NaCl 0.9%, was administered epidurally at the level of the lumbosacral space. Treatment P was administered to five dogs only. Cardiovascular and respiratory variables, blood gases, and oesophageal temperature were recorded at T-15 and for 60 minutes after epidural injection (T0). Results Mean overall heart rate (HR in beats minute(-1)) was significantly lower after treatment M (119 +/- 16) (p = 0.0019), R (110 +/- 18) (p < 0.0001) and RM (109 +/- 13) (p < 0.0001), compared to treatment P (135 +/- 21). Additionally, a significant difference in HR between treatments RM and M was found (p = 0.04). After both ropivacaine treatments, systemic arterial pressures (sAP) were significantly lower compared to other treatments. No significant overall differences between treatments were present for central venous pressure, cardiac output, stroke volume, systemic vascular resistance, oxygen delivery and arterial oxygen content (CaO2). Heart rate and sAP significantly increased after treatment P and M compared to baseline (T-15). With all treatments significant reductions from baseline were observed in oesophageal temperature, packed cell volume and CaO2. A transient unilateral Horner's syndrome occurred in one dog after treatment R. Conclusions and clinical relevance Clinically important low sAPs were observed after the ropivacaine epidural treatments in isoflurane anaesthetised dogs. Systemic arterial pressures were clinically acceptable when using epidural methadone.
Keywords
CORRECT PLACEMENT, POSTOPERATIVE ANALGESIA, HORNERS-SYNDROME, methadone, ropivacaine, TIME-RELATED RESPONSES, LATERALLY RECUMBENT, extradural, epidural, dog, cardiovascular, PRESSURE WAVES, ANESTHESIA, BUPIVACAINE, HALOTHANE, PROPOFOL

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MLA
Bosmans, Tim, Stijn Schauvliege, Frank Gasthuys, et al. “Cardiovascular Effects of Epidural Administration of Methadone, Ropivacaine 0.75% and Their Combination in Isoflurane Anaesthetized Dogs.” VETERINARY ANAESTHESIA AND ANALGESIA 38.2 (2011): 146–157. Print.
APA
Bosmans, T., Schauvliege, S., Gasthuys, F., Duchateau, L., Gozalo Marcilla, M., Gadeyne, C., & Polis, I. (2011). Cardiovascular effects of epidural administration of methadone, ropivacaine 0.75% and their combination in isoflurane anaesthetized dogs. VETERINARY ANAESTHESIA AND ANALGESIA, 38(2), 146–157.
Chicago author-date
Bosmans, Tim, Stijn Schauvliege, Frank Gasthuys, Luc Duchateau, Miguel Gozalo Marcilla, Caroline Gadeyne, and Ingeborgh Polis. 2011. “Cardiovascular Effects of Epidural Administration of Methadone, Ropivacaine 0.75% and Their Combination in Isoflurane Anaesthetized Dogs.” Veterinary Anaesthesia and Analgesia 38 (2): 146–157.
Chicago author-date (all authors)
Bosmans, Tim, Stijn Schauvliege, Frank Gasthuys, Luc Duchateau, Miguel Gozalo Marcilla, Caroline Gadeyne, and Ingeborgh Polis. 2011. “Cardiovascular Effects of Epidural Administration of Methadone, Ropivacaine 0.75% and Their Combination in Isoflurane Anaesthetized Dogs.” Veterinary Anaesthesia and Analgesia 38 (2): 146–157.
Vancouver
1.
Bosmans T, Schauvliege S, Gasthuys F, Duchateau L, Gozalo Marcilla M, Gadeyne C, et al. Cardiovascular effects of epidural administration of methadone, ropivacaine 0.75% and their combination in isoflurane anaesthetized dogs. VETERINARY ANAESTHESIA AND ANALGESIA. 2011;38(2):146–57.
IEEE
[1]
T. Bosmans et al., “Cardiovascular effects of epidural administration of methadone, ropivacaine 0.75% and their combination in isoflurane anaesthetized dogs,” VETERINARY ANAESTHESIA AND ANALGESIA, vol. 38, no. 2, pp. 146–157, 2011.
@article{1235056,
  abstract     = {Objective To compare the cardiovascular effects of four epidural treatments in isoflurane anaesthetised dogs.
Study design Prospective, randomized. experimental study.
Animals Six female, neutered Beagle dogs (13.3 +/- 1.0 kg), aged 3.6 +/- 0.1 years.
Methods Anaesthesia was induced with propofol (8.3 +/- 1.1 mg kg(-1)) and maintained with isoflurane in a mixture of oxygen and air [inspiratory fraction of oxygen (FiO(2)) = 40%], using intermittent positive pressure ventilation. Using a cross-over model, NaCl 0.9% (P); methadone 1% 0.1 mg kg(-1) (M); ropivacaine 0.75% 1.65 mg kg(-1) (R) or methadone 1% 0.1 mg kg(-1) + ropivacaine 0.75% 1.65 mg kg(-1) (RM) in equal volumes (0.23 mL kg(-1)) using NaCl 0.9%, was administered epidurally at the level of the lumbosacral space. Treatment P was administered to five dogs only. Cardiovascular and respiratory variables, blood gases, and oesophageal temperature were recorded at T-15 and for 60 minutes after epidural injection (T0).
Results Mean overall heart rate (HR in beats minute(-1)) was significantly lower after treatment M (119 +/- 16) (p = 0.0019), R (110 +/- 18) (p < 0.0001) and RM (109 +/- 13) (p < 0.0001), compared to treatment P (135 +/- 21). Additionally, a significant difference in HR between treatments RM and M was found (p = 0.04). After both ropivacaine treatments, systemic arterial pressures (sAP) were significantly lower compared to other treatments. No significant overall differences between treatments were present for central venous pressure, cardiac output, stroke volume, systemic vascular resistance, oxygen delivery and arterial oxygen content (CaO2). Heart rate and sAP significantly increased after treatment P and M compared to baseline (T-15). With all treatments significant reductions from baseline were observed in oesophageal temperature, packed cell volume and CaO2. A transient unilateral Horner's syndrome occurred in one dog after treatment R.
Conclusions and clinical relevance Clinically important low sAPs were observed after the ropivacaine epidural treatments in isoflurane anaesthetised dogs. Systemic arterial pressures were clinically acceptable when using epidural methadone.},
  author       = {Bosmans, Tim and Schauvliege, Stijn and Gasthuys, Frank and Duchateau, Luc and Gozalo Marcilla, Miguel and Gadeyne, Caroline and Polis, Ingeborgh},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keywords     = {CORRECT PLACEMENT,POSTOPERATIVE ANALGESIA,HORNERS-SYNDROME,methadone,ropivacaine,TIME-RELATED RESPONSES,LATERALLY RECUMBENT,extradural,epidural,dog,cardiovascular,PRESSURE WAVES,ANESTHESIA,BUPIVACAINE,HALOTHANE,PROPOFOL},
  language     = {eng},
  number       = {2},
  pages        = {146--157},
  title        = {Cardiovascular effects of epidural administration of methadone, ropivacaine 0.75% and their combination in isoflurane anaesthetized dogs},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2011.00595.x},
  volume       = {38},
  year         = {2011},
}

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