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Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A

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Abstract
Rationale: IL-22 has both proinflammatory and antiinflammatory properties. Its role in allergic lung inflammation has not been explored. Objectives: To investigate the expression and roles of IL-22 in the onset and resolution of experimental allergic asthma and its cross-talk with IL-17A. Methods: IL-22 expression was assessed in patient samples and in the lung of mice immunized and challenged with ovalbumin. IL-22 functions in allergic airway inflammation were evaluated using mice deficient in IL-22 or anti-IL-22 neutralizing antibodies. Moreover, the effects of recombinant IL-22 and IL-17A neutralizing antibodies were investigated. Measurements and Main Results: Increased pulmonary IL-22 expression is found in the serum of patients with asthma and mice immunized and challenged with ovalbumin. Allergic lung inflammation is IL-22 dependent because eosinophil recruitment, Th2 cytokine including IL-13 and IL-33, chemokine production, airway hyperreactivity, and mucus production are drastically reduced in mice deficient in IL-22 or by IL-22 antibody neutralization during immunization of wild-type mice. By contrast, IL-22 neutralization during antigen challenge enhanced allergic lung inflammation with increased Th2 cytokines. Consistent with this, recombinant IL-22 given with allergen challenge protects mice from lung inflammation. Finally, IL-22 may regulate the expression and proinflammatory properties of IL-17A in allergic lung inflammation. Conclusions: IL-22 is required for the onset of allergic asthma, but functions as a negative regulator of established allergic inflammation. Our study reveals that IL-22 contributes to the proinflammatory properties of IL-17A in experimental allergic asthma.
Keywords
INNATE IMMUNITY, T-CELLS, TH17 CELLS, INTERLEUKIN (IL)-22, NEGATIVE REGULATOR, DENDRITIC CELLS, HOST-DEFENSE, MOUSE MODEL, IFN-GAMMA, EXPRESSION, allergy, lung inflammation, Th2 response, IL-22, IL-17A

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MLA
Besnard, Anne-Gaelle, Robert Sabat , Laure Dumoutier, et al. “Dual Role of IL-22 in Allergic Airway Inflammation and Its Cross-talk with IL-17A.” AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 183.9 (2011): 1153–1163. Print.
APA
Besnard, A.-G., Sabat , R., Dumoutier, L., Renauld, J.-C., Willart, M., Lambrecht, B., Teixeira, M. M., et al. (2011). Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183(9), 1153–1163.
Chicago author-date
Besnard, Anne-Gaelle, Robert Sabat , Laure Dumoutier, Jean-Christophe Renauld, Monique Willart, Bart Lambrecht, Mauro M Teixeira, et al. 2011. “Dual Role of IL-22 in Allergic Airway Inflammation and Its Cross-talk with IL-17A.” American Journal of Respiratory and Critical Care Medicine 183 (9): 1153–1163.
Chicago author-date (all authors)
Besnard, Anne-Gaelle, Robert Sabat , Laure Dumoutier, Jean-Christophe Renauld, Monique Willart, Bart Lambrecht, Mauro M Teixeira, Sabine Charron, Lizette Fick, Francois Erard, Katarzyna Warszawska, Kerstin Wolk, Valerie Quesniaux, Bernhard Ryffel, and Dieudonnee Togbe. 2011. “Dual Role of IL-22 in Allergic Airway Inflammation and Its Cross-talk with IL-17A.” American Journal of Respiratory and Critical Care Medicine 183 (9): 1153–1163.
Vancouver
1.
Besnard A-G, Sabat R, Dumoutier L, Renauld J-C, Willart M, Lambrecht B, et al. Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183(9):1153–63.
IEEE
[1]
A.-G. Besnard et al., “Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A,” AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 183, no. 9, pp. 1153–1163, 2011.
@article{1234726,
  abstract     = {Rationale: IL-22 has both proinflammatory and antiinflammatory properties. Its role in allergic lung inflammation has not been explored. Objectives: To investigate the expression and roles of IL-22 in the onset and resolution of experimental allergic asthma and its cross-talk with IL-17A. Methods: IL-22 expression was assessed in patient samples and in the lung of mice immunized and challenged with ovalbumin. IL-22 functions in allergic airway inflammation were evaluated using mice deficient in IL-22 or anti-IL-22 neutralizing antibodies. Moreover, the effects of recombinant IL-22 and IL-17A neutralizing antibodies were investigated. Measurements and Main Results: Increased pulmonary IL-22 expression is found in the serum of patients with asthma and mice immunized and challenged with ovalbumin. Allergic lung inflammation is IL-22 dependent because eosinophil recruitment, Th2 cytokine including IL-13 and IL-33, chemokine production, airway hyperreactivity, and mucus production are drastically reduced in mice deficient in IL-22 or by IL-22 antibody neutralization during immunization of wild-type mice. By contrast, IL-22 neutralization during antigen challenge enhanced allergic lung inflammation with increased Th2 cytokines. Consistent with this, recombinant IL-22 given with allergen challenge protects mice from lung inflammation. Finally, IL-22 may regulate the expression and proinflammatory properties of IL-17A in allergic lung inflammation. Conclusions: IL-22 is required for the onset of allergic asthma, but functions as a negative regulator of established allergic inflammation. Our study reveals that IL-22 contributes to the proinflammatory properties of IL-17A in experimental allergic asthma.},
  author       = {Besnard, Anne-Gaelle and Sabat , Robert and Dumoutier, Laure and Renauld, Jean-Christophe and Willart, Monique and Lambrecht, Bart and Teixeira, Mauro M and Charron, Sabine and Fick, Lizette and Erard, Francois and Warszawska, Katarzyna and Wolk, Kerstin and Quesniaux, Valerie and Ryffel, Bernhard and Togbe, Dieudonnee},
  issn         = {1073-449X},
  journal      = {AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE},
  keywords     = {INNATE IMMUNITY,T-CELLS,TH17 CELLS,INTERLEUKIN (IL)-22,NEGATIVE REGULATOR,DENDRITIC CELLS,HOST-DEFENSE,MOUSE MODEL,IFN-GAMMA,EXPRESSION,allergy,lung inflammation,Th2 response,IL-22,IL-17A},
  language     = {eng},
  number       = {9},
  pages        = {1153--1163},
  title        = {Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A},
  url          = {http://dx.doi.org/10.1164/rccm.201008-1383OC},
  volume       = {183},
  year         = {2011},
}

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