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Voice-related quality of life in adults with neurofibromatosis type 1

Marjan Cosyns UGent, Geert Mortier UGent, Sandra Janssens UGent and John Van Borsel UGent (2011) Wetenschapsdag faculteit geneeskunde en gezondheidswetenschappen, Abstracts.
abstract
Aims. Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder with an estimated prevalence of 1 in 3,000 to 4,000. Its hallmark features include multiple café-au-lait spots and neurofibromas. Voice characteristics of NF1 patients have been documented using both subjective and objective evaluations. Objective assessment showed that NF1 patients exhibited poorer voice quality compared to healthy controls characterized by limitations in laryngeal possibilities with respect to frequency and intensity as well as a reduced vital capacity. However, the relative impact of these voice abnormalities upon daily activities has, as far as we know, not been examined yet. Methods. Adults with NF1 were asked to complete the Dutch version of the Voice Handicap Index (VHI). Their results were compared to a healthy control group frequency matched for age, gender, smoking behavior and vocal usage. Additionally, for the patient group, Dysphonia Severity Indices obtained in a previous study (Cosyns et al., 2010) were collected and the level of severity of the NF1 was rated. Results. NF1 patients achieved significantly higher scores on the VHI compared to healthy controls. The overall VHI score for the patient group ranged between 0 and 63 (mean = 25.10, SD = 18.85) and was equal to or higher than 15, which is the cut-off point proposed by Van Gogh et al. (2007), in 68.97% of cases. VHI scores did not differ significantly between male and female NF1 patients nor was it possible to establish a correlation between total VHI score on the one hand and DSI and severity rating on the other. However, we did find a positive correlation between total VHI score and age. Conclusion. These results suggest that NF1 patients experience greater psychosocial consequences of their eventual voice abnormalities compared to healthy controls. Given their impact upon daily activities, voice abnormalities associated with NF1 may considered to be voice problems as such, at least in the majority of patients.
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author
organization
year
type
conference
publication status
unpublished
subject
in
Wetenschapsdag faculteit geneeskunde en gezondheidswetenschappen, Abstracts
conference name
Wetenschapsdag Faculteit Geneeskunde en Gezondheidswetenschappen
conference location
Ghent, Belgium
conference start
2011-04-07
conference end
2011-04-07
language
English
UGent publication?
yes
classification
C3
copyright statement
I have retained and own the full copyright for this publication
id
1232145
handle
http://hdl.handle.net/1854/LU-1232145
date created
2011-05-24 10:11:59
date last changed
2011-06-15 15:24:28
@inproceedings{1232145,
  abstract     = {Aims. Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder with an estimated prevalence of 1 in 3,000 to 4,000. Its hallmark features include multiple caf{\'e}-au-lait spots and neurofibromas. Voice characteristics of NF1 patients have been documented using both subjective and objective evaluations. Objective assessment showed that NF1 patients exhibited poorer voice quality compared to healthy controls characterized by limitations in laryngeal possibilities with respect to frequency and intensity as well as a reduced vital capacity. However, the relative impact of these voice abnormalities upon daily activities has, as far as we know, not been examined yet. Methods. Adults with NF1 were asked to complete the Dutch version of the Voice Handicap Index (VHI). Their results were compared to a healthy control group frequency matched for age, gender, smoking behavior and vocal usage. Additionally, for the patient group, Dysphonia Severity Indices obtained in a previous study (Cosyns et al., 2010) were collected and the level of severity of the NF1 was rated. Results. NF1 patients achieved significantly higher scores on the VHI compared to healthy controls. The overall VHI score for the patient group ranged between 0 and 63 (mean = 25.10, SD = 18.85) and was equal to or higher than 15, which is the cut-off point proposed by Van Gogh et al. (2007), in 68.97\% of cases. VHI scores did not differ significantly between male and female NF1 patients nor was it possible to establish a correlation between total VHI score on the one hand and DSI and severity rating on the other. However, we did find a positive correlation between total VHI score and age. Conclusion. These results suggest that NF1 patients experience greater psychosocial consequences of their eventual voice abnormalities compared to healthy controls. Given their impact upon daily activities, voice abnormalities associated with NF1 may considered to be voice problems as such, at least in the majority of patients.},
  author       = {Cosyns, Marjan and Mortier, Geert and Janssens, Sandra and Van Borsel, John},
  booktitle    = {Wetenschapsdag faculteit geneeskunde en gezondheidswetenschappen, Abstracts},
  language     = {eng},
  location     = {Ghent, Belgium},
  title        = {Voice-related quality of life in adults with neurofibromatosis type 1},
  year         = {2011},
}

Chicago
Cosyns, Marjan, Geert Mortier, Sandra Janssens, and John Van Borsel. 2011. “Voice-related Quality of Life in Adults with Neurofibromatosis Type 1.” In Wetenschapsdag Faculteit Geneeskunde En Gezondheidswetenschappen, Abstracts.
APA
Cosyns, Marjan, Mortier, G., Janssens, S., & Van Borsel, J. (2011). Voice-related quality of life in adults with neurofibromatosis type 1. Wetenschapsdag faculteit geneeskunde en gezondheidswetenschappen, Abstracts. Presented at the Wetenschapsdag Faculteit Geneeskunde en Gezondheidswetenschappen.
Vancouver
1.
Cosyns M, Mortier G, Janssens S, Van Borsel J. Voice-related quality of life in adults with neurofibromatosis type 1. Wetenschapsdag faculteit geneeskunde en gezondheidswetenschappen, Abstracts. 2011.
MLA
Cosyns, Marjan, Geert Mortier, Sandra Janssens, et al. “Voice-related Quality of Life in Adults with Neurofibromatosis Type 1.” Wetenschapsdag Faculteit Geneeskunde En Gezondheidswetenschappen, Abstracts. 2011. Print.