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Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects

(2010) NANOMEDICINE. 5(8). p.1261-1275
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Abstract
The in vitro labeling of stem or therapeutic cells with engineered nanoparticles with the aim of transplanting these cells into live animals and, for example, noninvasively monitoring their migration, is a hot topic in nanomedicine research. It is of crucial importance that cell-nanoparticle interactions are studied in depth in order to exclude any negative effects of the cell labeling procedure. To date, many disparate results can be found in the literature regarding nanoparticle toxicity due to the great versatility of different parameters investigated. In the present work, an overview is presented of different types of nanomaterials, focusing mostly on iron oxide nanoparticles, developed for biomedical research. The difficulties in assessing nanoparticle-mediated toxicity are discussed, an overview of some of the problems encountered using commercial (dextran-coated) iron oxide nanoparticles is presented, several key parameters are highlighted and novel methods suggested emphasizing the importance of intracellular nanoparticle degradation and linking toxicity data to functional (i.e., cell-associated) nanoparticle levels, which could help to advance any progress in this highly important research topic.
Keywords
nanoparticle, iron oxide, magnetoliposome, cell labeling, cytotoxicity, biomedical materials, MAGNETOLIPOSOMES, CYTOTOXICITY, QUANTUM DOTS, INTRACELLULAR UPTAKE, TARGETED DRUG-DELIVERY, MR CONTRAST AGENTS, MAGNETIC NANOPARTICLES, CELLULAR UPTAKE, MESENCHYMAL STEM-CELLS, WALLED CARBON NANOTUBES

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Citation

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Chicago
Soenen, Stefaan, and Marcel De Cuyper. 2010. “Assessing Iron Oxide Nanoparticle Toxicity in Vitro: Current Status and Future Prospects.” Nanomedicine 5 (8): 1261–1275.
APA
Soenen, S., & De Cuyper, M. (2010). Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects. NANOMEDICINE, 5(8), 1261–1275.
Vancouver
1.
Soenen S, De Cuyper M. Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects. NANOMEDICINE. 2010;5(8):1261–75.
MLA
Soenen, Stefaan, and Marcel De Cuyper. “Assessing Iron Oxide Nanoparticle Toxicity in Vitro: Current Status and Future Prospects.” NANOMEDICINE 5.8 (2010): 1261–1275. Print.
@article{1231660,
  abstract     = {The in vitro labeling of stem or therapeutic cells with engineered nanoparticles with the aim of transplanting these cells into live animals and, for example, noninvasively monitoring their migration, is a hot topic in nanomedicine research. It is of crucial importance that cell-nanoparticle interactions are studied in depth in order to exclude any negative effects of the cell labeling procedure. To date, many disparate results can be found in the literature regarding nanoparticle toxicity due to the great versatility of different parameters investigated. In the present work, an overview is presented of different types of nanomaterials, focusing mostly on iron oxide nanoparticles, developed for biomedical research. The difficulties in assessing nanoparticle-mediated toxicity are discussed, an overview of some of the problems encountered using commercial (dextran-coated) iron oxide nanoparticles is presented, several key parameters are highlighted and novel methods suggested emphasizing the importance of intracellular nanoparticle degradation and linking toxicity data to functional (i.e., cell-associated) nanoparticle levels, which could help to advance any progress in this highly important research topic.},
  author       = {Soenen, Stefaan and De Cuyper, Marcel},
  issn         = {1743-5889},
  journal      = {NANOMEDICINE},
  keyword      = {nanoparticle,iron oxide,magnetoliposome,cell labeling,cytotoxicity,biomedical materials,MAGNETOLIPOSOMES,CYTOTOXICITY,QUANTUM DOTS,INTRACELLULAR UPTAKE,TARGETED DRUG-DELIVERY,MR CONTRAST AGENTS,MAGNETIC NANOPARTICLES,CELLULAR UPTAKE,MESENCHYMAL STEM-CELLS,WALLED CARBON NANOTUBES},
  language     = {eng},
  number       = {8},
  pages        = {1261--1275},
  title        = {Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects},
  url          = {http://dx.doi.org/10.2217/NNM.10.106},
  volume       = {5},
  year         = {2010},
}

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