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Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality

Stefaan Soenen UGent, Uwe Himmelreich, Nele Nuytten UGent, Thomas Pisanic, Aldo Ferrari and Marcel De Cuyper (2010) SMALL. 6(19). p.2136-2145
abstract
Iron oxide nanoparticles (NPs) are frequently employed in biomedical research as magnetic resonance (MR) contrast agents where high intracellular levels are required to clearly depict signal alterations. To date, the toxicity and applicability of these particles have not been completely unraveled. Here, we show that endosomal localization of different iron oxide particles results in their degradation and in reduced MR contrast, the rate of which is governed mainly by the stability of the coating. The release of ferric iron generates reactive species, which greatly affect cell functionality. Lipid-coated NPs display the highest stability and furthermore exhibit intracellular clustering, which significantly enhances their MR properties and intracellular persistence. These findings are of considerable importance because, depending on the nature of the coating, particles can be rapidly degraded, thus completely annihilating their MR contrast to levels not detectable when compared to controls and greatly impeding cell functionality, thereby hindering their application in functional in vivo studies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CONTRAST AGENT, VIVO, STEM-CELLS, IN-VITRO, SUPERPARAMAGNETIC IRON-OXIDE, TRANSFERRIN RECEPTOR, MAGNETOLIPOSOMES, EXPRESSION, PARTICLES, TRACKING
journal title
SMALL
Small
volume
6
issue
19
pages
2136 - 2145
Web of Science type
Article
Web of Science id
000283274100011
JCR category
MATERIALS SCIENCE, MULTIDISCIPLINARY
JCR impact factor
7.333 (2010)
JCR rank
11/219 (2010)
JCR quartile
1 (2010)
ISSN
1613-6810
DOI
10.1002/smll.201000763
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1231640
handle
http://hdl.handle.net/1854/LU-1231640
date created
2011-05-24 09:27:11
date last changed
2012-08-06 12:12:49
@article{1231640,
  abstract     = {Iron oxide nanoparticles (NPs) are frequently employed in biomedical research as magnetic resonance (MR) contrast agents where high intracellular levels are required to clearly depict signal alterations. To date, the toxicity and applicability of these particles have not been completely unraveled. Here, we show that endosomal localization of different iron oxide particles results in their degradation and in reduced MR contrast, the rate of which is governed mainly by the stability of the coating. The release of ferric iron generates reactive species, which greatly affect cell functionality. Lipid-coated NPs display the highest stability and furthermore exhibit intracellular clustering, which significantly enhances their MR properties and intracellular persistence. These findings are of considerable importance because, depending on the nature of the coating, particles can be rapidly degraded, thus completely annihilating their MR contrast to levels not detectable when compared to controls and greatly impeding cell functionality, thereby hindering their application in functional in vivo studies.},
  author       = {Soenen, Stefaan and Himmelreich, Uwe and Nuytten, Nele and Pisanic, Thomas and Ferrari, Aldo and De Cuyper, Marcel},
  issn         = {1613-6810},
  journal      = {SMALL},
  keyword      = {CONTRAST AGENT,VIVO,STEM-CELLS,IN-VITRO,SUPERPARAMAGNETIC IRON-OXIDE,TRANSFERRIN RECEPTOR,MAGNETOLIPOSOMES,EXPRESSION,PARTICLES,TRACKING},
  language     = {eng},
  number       = {19},
  pages        = {2136--2145},
  title        = {Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality},
  url          = {http://dx.doi.org/10.1002/smll.201000763},
  volume       = {6},
  year         = {2010},
}

Chicago
Soenen, Stefaan, Uwe Himmelreich, Nele Nuytten, Thomas Pisanic, Aldo Ferrari, and Marcel De Cuyper. 2010. “Intracellular Nanoparticle Coating Stability Determines Nanoparticle Diagnostics Efficacy and Cell Functionality.” Small 6 (19): 2136–2145.
APA
Soenen, S., Himmelreich, U., Nuytten, N., Pisanic, T., Ferrari, A., & De Cuyper, M. (2010). Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality. SMALL, 6(19), 2136–2145.
Vancouver
1.
Soenen S, Himmelreich U, Nuytten N, Pisanic T, Ferrari A, De Cuyper M. Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality. SMALL. 2010;6(19):2136–45.
MLA
Soenen, Stefaan, Uwe Himmelreich, Nele Nuytten, et al. “Intracellular Nanoparticle Coating Stability Determines Nanoparticle Diagnostics Efficacy and Cell Functionality.” SMALL 6.19 (2010): 2136–2145. Print.