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Voice characteristics in adults with neurofibromatosis type 1

Marjan Cosyns, Geert Mortier, Paul Corthals UGent, Sandra Janssens and John Van Borsel UGent (2010) 2010 NF conference, Abstracts.
abstract
Introduction and aims of the study: Change or loss of voice in patients with neurofibromatosis type 1 (NF1) has been associated with head and neck neurofibromas. However, laryngeal involvement in NF1 is rare and voice abnormalities have also been reported in absence of such a tumor. Authors mention the occurrence of deviations in voice quality (such as breathiness, hoarseness, harshness, presence of a creak) and problems in regulating pitch and loudness. These studies are mainly based on perceptual evaluations. Therefore, the purpose of this study was to examine the voice characteristics of adult NF1 patients without laryngeal manifestations using a multiparameter approach. Methods: A total of 22 NF1 patients (age range 17-64 years) and 22 controls (age range 18-67 years) participated in the study. The patient group consisted of 9 males (mean age 39,33 years) and 13 females (mean age 32,69 years). The control group consisted of 12 males (mean age 38,00 years) and 10 females (mean age 32,90 years). Voice characteristics were evaluated using aerodynamic, voice range and acoustic measurements. These measurements allowed us to determine the Dysphonia Severity Index (DSI). Additionally, participants were asked to complete the Voice Handicap Index (VHI), a questionnaire concerning voice-related quality of life. Results: Vital capacity was significantly reduced in NF1 patients compared with controls. Also, the frequency and intensity range were significantly narrower in the patient group compared with controls. The narrower frequency and intensity range were due to a significantly lower highest frequency and a significantly lower highest intensity respectively. Additionally, male NF1 patients showed a significantly higher lowest intensity compared with male controls. Further, during reading, female NF1 patients exhibited a significantly smaller standard deviation of the mean frequency compared with female controls. This trend was also observed in the male NF1 patients compared with male controls. However, a significant difference could not be demonstrated. Finally, DSI scores were significantly lower and VHI values were significantly higher in both sexes of the patient group compared with controls. Conclusion: NF1 patients appear to have a vocal quality that is worse compared with controls. In particular, it seems that NF1 patients have reduced laryngeal possibilities with respect to fundamental frequency and sound intensity compared with controls. They are also more likely to present a more marked psychosocial voice impact compared with controls.
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author
organization
year
type
conference
publication status
unpublished
subject
in
2010 NF conference, Abstracts
conference name
2010 NF Conference
conference location
Baltimore, MD, USA
conference start
2010-06-05
conference end
2010-06-08
language
English
UGent publication?
yes
classification
C3
copyright statement
I have retained and own the full copyright for this publication
id
1231463
handle
http://hdl.handle.net/1854/LU-1231463
date created
2011-05-24 09:03:10
date last changed
2016-12-19 15:36:26
@inproceedings{1231463,
  abstract     = {Introduction and aims of the study: Change or loss of voice in patients with neurofibromatosis type 1 (NF1) has been associated with head and neck neurofibromas. However, laryngeal involvement in NF1 is rare and voice abnormalities have also been reported in absence of such a tumor. Authors mention the occurrence of deviations in voice quality (such as breathiness, hoarseness, harshness, presence of a creak) and problems in regulating pitch and loudness. These studies are mainly based on perceptual evaluations. Therefore, the purpose of this study was to examine the voice characteristics of adult NF1 patients without laryngeal manifestations using a multiparameter approach. Methods: A total of 22 NF1 patients (age range 17-64 years) and 22 controls (age range 18-67 years) participated in the study. The patient group consisted of 9 males (mean age 39,33 years) and 13 females (mean age 32,69 years). The control group consisted of 12 males (mean age 38,00 years) and 10 females (mean age 32,90 years). Voice characteristics were evaluated using aerodynamic, voice range and acoustic measurements. These measurements allowed us to determine the Dysphonia Severity Index (DSI). Additionally, participants were asked to complete the Voice Handicap Index (VHI), a questionnaire concerning voice-related quality of life. Results: Vital capacity was significantly reduced in NF1 patients compared with controls. Also, the frequency and intensity range were significantly narrower in the patient group compared with controls. The narrower frequency and intensity range were due to a significantly lower highest frequency and a significantly lower highest intensity respectively. Additionally, male NF1 patients showed a significantly higher lowest intensity compared with male controls. Further, during reading, female NF1 patients exhibited a significantly smaller standard deviation of the mean frequency compared with female controls. This trend was also observed in the male NF1 patients compared with male controls. However, a significant difference could not be demonstrated. Finally, DSI scores were significantly lower and VHI values were significantly higher in both sexes of the patient group compared with controls. Conclusion: NF1 patients appear to have a vocal quality that is worse compared with controls. In particular, it seems that NF1 patients have reduced laryngeal possibilities with respect to fundamental frequency and sound intensity compared with controls. They are also more likely to present a more marked psychosocial voice impact compared with controls.},
  author       = {Cosyns, Marjan and Mortier, Geert and Corthals, Paul and Janssens, Sandra and Van Borsel, John},
  booktitle    = {2010 NF conference, Abstracts},
  language     = {eng},
  location     = {Baltimore, MD, USA},
  title        = {Voice characteristics in adults with neurofibromatosis type 1},
  year         = {2010},
}

Chicago
Cosyns, Marjan, Geert Mortier, Paul Corthals, Sandra Janssens, and John Van Borsel. 2010. “Voice Characteristics in Adults with Neurofibromatosis Type 1.” In 2010 NF Conference, Abstracts.
APA
Cosyns, Marjan, Mortier, G., Corthals, P., Janssens, S., & Van Borsel, J. (2010). Voice characteristics in adults with neurofibromatosis type 1. 2010 NF conference, Abstracts. Presented at the 2010 NF Conference.
Vancouver
1.
Cosyns M, Mortier G, Corthals P, Janssens S, Van Borsel J. Voice characteristics in adults with neurofibromatosis type 1. 2010 NF conference, Abstracts. 2010.
MLA
Cosyns, Marjan, Geert Mortier, Paul Corthals, et al. “Voice Characteristics in Adults with Neurofibromatosis Type 1.” 2010 NF Conference, Abstracts. 2010. Print.