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Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation

(2010) JOURNAL OF EXPERIMENTAL MEDICINE. 207(9). p.2019-2031
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Abstract
End-stage liver disease caused by chronic hepatitis C virus (HCV) infection is a leading cause for liver transplantation (LT). Due to viral evasion from host immune responses and the absence of preventive antiviral strategies, reinfection of the graft is universal. The mechanisms by which the virus evades host immunity to reinfect the liver graft are unknown. In a longitudinal analysis of six HCV-infected patients undergoing LT, we demonstrate that HCV variants reinfecting the liver graft were characterized by efficient entry and poor neutralization by antibodies present in pretransplant serum compared with variants not detected after transplantation. Monoclonal antibodies directed against HCV envelope glycoproteins or a cellular entry factor efficiently cross-neutralized infection of human hepatocytes by patient-derived viral isolates that were resistant to autologous host-neutralizing responses. These findings provide significant insights into the molecular mechanisms of viral evasion during HCV reinfection and suggest that viral entry is a viable target for prevention of HCV reinfection of the liver graft.
Keywords
E2 ENVELOPE GLYCOPROTEIN, CELL TRANSMISSION, SCAVENGER RECEPTOR-BI, EVOLUTION, EPITOPE, RESPONSES, INFECTION, CD81, SOURCE OUTBREAK, HEPATOMA-CELLS

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Chicago
Fafi-Kremer, Samira, Isabel Fofana, Eric Soulier, Patric Carolla, Philip Meuleman, Geert Leroux-Roels, Arvind H Patel, et al. 2010. “Viral Entry and Escape from Antibody-mediated Neutralization Influence Hepatitis C Virus Reinfection in Liver Transplantation.” Journal of Experimental Medicine 207 (9): 2019–2031.
APA
Fafi-Kremer, S., Fofana, I., Soulier, E., Carolla, P., Meuleman, P., Leroux-Roels, G., Patel, A. H., et al. (2010). Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation. JOURNAL OF EXPERIMENTAL MEDICINE, 207(9), 2019–2031.
Vancouver
1.
Fafi-Kremer S, Fofana I, Soulier E, Carolla P, Meuleman P, Leroux-Roels G, et al. Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation. JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(9):2019–31.
MLA
Fafi-Kremer, Samira, Isabel Fofana, Eric Soulier, et al. “Viral Entry and Escape from Antibody-mediated Neutralization Influence Hepatitis C Virus Reinfection in Liver Transplantation.” JOURNAL OF EXPERIMENTAL MEDICINE 207.9 (2010): 2019–2031. Print.
@article{1231206,
  abstract     = {End-stage liver disease caused by chronic hepatitis C virus (HCV) infection is a leading cause for liver transplantation (LT). Due to viral evasion from host immune responses and the absence of preventive antiviral strategies, reinfection of the graft is universal. The mechanisms by which the virus evades host immunity to reinfect the liver graft are unknown. In a longitudinal analysis of six HCV-infected patients undergoing LT, we demonstrate that HCV variants reinfecting the liver graft were characterized by efficient entry and poor neutralization by antibodies present in pretransplant serum compared with variants not detected after transplantation. Monoclonal antibodies directed against HCV envelope glycoproteins or a cellular entry factor efficiently cross-neutralized infection of human hepatocytes by patient-derived viral isolates that were resistant to autologous host-neutralizing responses. These findings provide significant insights into the molecular mechanisms of viral evasion during HCV reinfection and suggest that viral entry is a viable target for prevention of HCV reinfection of the liver graft.},
  author       = {Fafi-Kremer, Samira and Fofana, Isabel and Soulier, Eric and Carolla, Patric and Meuleman, Philip and Leroux-Roels, Geert and Patel, Arvind H and Cosset, Fran\c{c}ois-Loic and Pessaux, Patrick and Doffoel, Michel and Wolf, Philippe and Stoll-Keller, Fran\c{c}oise and Baumert, Thomas F},
  issn         = {0022-1007},
  journal      = {JOURNAL OF EXPERIMENTAL MEDICINE},
  language     = {eng},
  number       = {9},
  pages        = {2019--2031},
  title        = {Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation},
  url          = {http://dx.doi.org/10.1084/jem.20090766},
  volume       = {207},
  year         = {2010},
}

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