Advanced search
1 file | 598.05 KB

Glucocorticoid receptor mutants: man-made tools for functional research

Author
Organization
Abstract
The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that can bind to glucocorticoids (GCs). Upon ligand binding, GR sheds its cytoplasmic chaperoning complex and translocates to the nucleus, where it can act as a ligand-dependent transcription factor, transactivating or transrepressing specific gene promoters. Often, GR interacts with specific cofactors to implement a variety of gene promoter effects. GR activity and function is further modulated by post-translational modifications. To assess the diverse aspects of GR mechanisms of activation and gene regulation, researchers continue to use a range of artificial GR mutants. In this review we analyze the characteristics of GR mutants with the aim of assisting the design and interpretation of GR mutant-based experiments.
Keywords
mutant, glucocorticoid receptor, inflammation, glucocorticoids, technical, NF-KAPPA-B, LIGAND-BINDING DOMAIN, STEROID-HORMONE RECEPTORS, GASTRIC-ACID-SECRETION, DNA-BINDING, TRANSCRIPTIONAL ACTIVATION, NUCLEAR EXPORT, GENE-EXPRESSION, HSP90 BINDING, HINGE REGION

Downloads

    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 598.05 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Beck, Ilse, Karolien De Bosscher, and Guy Haegeman. 2011. “Glucocorticoid Receptor Mutants: Man-made Tools for Functional Research.” Trends in Endocrinology and Metabolism 22 (8): 295–310.
APA
Beck, I., De Bosscher, K., & Haegeman, G. (2011). Glucocorticoid receptor mutants: man-made tools for functional research. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 22(8), 295–310.
Vancouver
1.
Beck I, De Bosscher K, Haegeman G. Glucocorticoid receptor mutants: man-made tools for functional research. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2011;22(8):295–310.
MLA
Beck, Ilse, Karolien De Bosscher, and Guy Haegeman. “Glucocorticoid Receptor Mutants: Man-made Tools for Functional Research.” TRENDS IN ENDOCRINOLOGY AND METABOLISM 22.8 (2011): 295–310. Print.
@article{1229729,
  abstract     = {The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that can bind to glucocorticoids (GCs). Upon ligand binding, GR sheds its cytoplasmic chaperoning complex and translocates to the nucleus, where it can act as a ligand-dependent transcription factor, transactivating or transrepressing specific gene promoters. Often, GR interacts with specific cofactors to implement a variety of gene promoter effects. GR activity and function is further modulated by post-translational modifications. To assess the diverse aspects of GR mechanisms of activation and gene regulation, researchers continue to use a range of artificial GR mutants. In this review we analyze the characteristics of GR mutants with the aim of assisting the design and interpretation of GR mutant-based experiments.},
  author       = {Beck, Ilse and De Bosscher, Karolien and Haegeman, Guy},
  issn         = {1043-2760},
  journal      = {TRENDS IN ENDOCRINOLOGY AND METABOLISM},
  keyword      = {mutant,glucocorticoid receptor,inflammation,glucocorticoids,technical,NF-KAPPA-B,LIGAND-BINDING DOMAIN,STEROID-HORMONE RECEPTORS,GASTRIC-ACID-SECRETION,DNA-BINDING,TRANSCRIPTIONAL ACTIVATION,NUCLEAR EXPORT,GENE-EXPRESSION,HSP90 BINDING,HINGE REGION},
  language     = {eng},
  number       = {8},
  pages        = {295--310},
  title        = {Glucocorticoid receptor mutants: man-made tools for functional research},
  url          = {http://dx.doi.org/10.1016/j.tem.2011.03.009},
  volume       = {22},
  year         = {2011},
}

Altmetric
View in Altmetric
Web of Science
Times cited: