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Viruses and cytotoxic T lymphocytes in type 1 diabetes

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Abstract
Histopathological studies on pancreas tissues from individuals with recent-onset type 1 diabetes (T1D) consistently find that CD8 T cells substantially contribute to the formation of islet lesions. CD8 T cells reactive against islet-associated antigens can also be found in blood samples from T1D patients. Mechanistic studies on the pathogenic role of this T cell subset have mostly focused on two animal models, i.e., the non-obese diabetic mouse and the virally induced rat insulin promoter-lymphocytic choriomeningitis virus model. Data were obtained in support of a role for viral infection in expanding a population of diabetogenic cytotoxic T lymphocytes. In view of the theorized association of viral infection with initiation of islet autoimmunity and progression to clinically overt disease, CD8 T cells thus represent an attractive target for immunotherapy. We will review here arguments in favor of a pivotal role for CD8 T cells in driving T1D development and speculate on etiologic agents that may provoke their aberrant activation.
Keywords
Autoimmunity, Type 1 diabetes, CD8 T cells, CTL, Beta cells, PANCREATIC BETA-CELLS, GLUTAMIC-ACID DECARBOXYLASE, MHC CLASS-I, PERIPHERAL-BLOOD, IFN-GAMMA, NOD MICE, FAS LIGAND, ENTEROVIRUS INFECTION, ADHESION MOLECULES, ISLET AUTOIMMUNITY

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Chicago
Coppieters, Ken, and Matthias G von Herrath. 2011. “Viruses and Cytotoxic T Lymphocytes in Type 1 Diabetes.” Clinical Reviews in Allergy & Immunology 41 (2): 169–178.
APA
Coppieters, K., & von Herrath, M. G. (2011). Viruses and cytotoxic T lymphocytes in type 1 diabetes. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 41(2), 169–178.
Vancouver
1.
Coppieters K, von Herrath MG. Viruses and cytotoxic T lymphocytes in type 1 diabetes. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY. 2011;41(2):169–78.
MLA
Coppieters, Ken, and Matthias G von Herrath. “Viruses and Cytotoxic T Lymphocytes in Type 1 Diabetes.” CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY 41.2 (2011): 169–178. Print.
@article{1229546,
  abstract     = {Histopathological studies on pancreas tissues from individuals with recent-onset type 1 diabetes (T1D) consistently find that CD8 T cells substantially contribute to the formation of islet lesions. CD8 T cells reactive against islet-associated antigens can also be found in blood samples from T1D patients. Mechanistic studies on the pathogenic role of this T cell subset have mostly focused on two animal models, i.e., the non-obese diabetic mouse and the virally induced rat insulin promoter-lymphocytic choriomeningitis virus model. Data were obtained in support of a role for viral infection in expanding a population of diabetogenic cytotoxic T lymphocytes. In view of the theorized association of viral infection with initiation of islet autoimmunity and progression to clinically overt disease, CD8 T cells thus represent an attractive target for immunotherapy. We will review here arguments in favor of a pivotal role for CD8 T cells in driving T1D development and speculate on etiologic agents that may provoke their aberrant activation.},
  author       = {Coppieters, Ken and von Herrath, Matthias G},
  issn         = {1080-0549},
  journal      = {CLINICAL REVIEWS IN ALLERGY \& IMMUNOLOGY},
  keyword      = {Autoimmunity,Type 1 diabetes,CD8 T cells,CTL,Beta cells,PANCREATIC BETA-CELLS,GLUTAMIC-ACID DECARBOXYLASE,MHC CLASS-I,PERIPHERAL-BLOOD,IFN-GAMMA,NOD MICE,FAS LIGAND,ENTEROVIRUS INFECTION,ADHESION MOLECULES,ISLET AUTOIMMUNITY},
  language     = {eng},
  number       = {2},
  pages        = {169--178},
  title        = {Viruses and cytotoxic T lymphocytes in type 1 diabetes},
  url          = {http://dx.doi.org/10.1007/s12016-010-8220-4},
  volume       = {41},
  year         = {2011},
}

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