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19F MRI oximetry: simulation of perfluorocarbon distribution impact

Steven Baete UGent, Jan Vandecasteele UGent and Yves De Deene UGent (2011) PHYSICS IN MEDICINE AND BIOLOGY. 56(8). p.2535-2557
abstract
In (FMRI)-F-19 oximetry, a method used to image tumour hypoxia, perfluorocarbons serve as oxygenation markers. The goal of this study is to evaluate the impact of perfluorocarbon distribution and concentration in (FMRI)-F-19 oximetry through a computer simulation. The simulation studies the correspondence between F-19 measured (pO(2)(FNMR)) and actual tissue oxygen tension (pO(2)) for several tissue perfluorocarbon distributions. For this, a Krogh tissue model is implemented which incorporates the presence of perfluorocarbons in blood and tissue. That is, in tissue the perfluorocarbons are distributed homogeneously according to Gaussian diffusion profiles, or the perfluorocarbons are concentrated in the capillary wall. Using these distributions, the oxygen tension in the simulation volume is calculated. The simulated mean oxygen tension is then compared with pO(2)(FNMR), the F-19 MRI-based measure of pO(2) and with pO(2)(0), pO(2) in the absence of perfluorocarbons. The agreement between pO(2)(FNMR) and actual pO(2) is influenced by vascular density and perfluorocarbon distribution. The presence of perfluorocarbons generally gives rise to a pO(2) increase in tissue. This effect is enhanced when perfluorocarbons are also present in blood. Only the homogeneous perfluorocarbon distribution in tissue with no perfluorocarbons in blood guarantees small deviations of pO(2)(FNMR) from pO(2). Hence, perfluorocarbon distribution in tissue and blood has a serious impact on the reliability of F-19 MRI-based measures of oxygen tension. In addition, the presence of perfluorocarbons influences the actual oxygen tension. This finding may be of great importance for further development of F-19 MRI oximetry.
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author
organization
alternative title
F-19 MRI oximetry : simulation of perfluorocarbon distribution impact
year
type
journalArticle (original)
publication status
published
subject
keyword
MARROW HEMATOPOIETIC COMPARTMENT, MODELING PO(2) DISTRIBUTIONS, MULTICELLULAR TUMOR SPHEROIDS, CELLULAR-AUTOMATON MODEL, MAGNETIC-RESONANCE, OXYGEN-TRANSPORT, TISSUE OXYGENATION, THEORETICAL SIMULATION, RESPIRATORY CHALLENGE, EMULSION MIXTURES
journal title
PHYSICS IN MEDICINE AND BIOLOGY
Phys. Med. Biol.
volume
56
issue
8
pages
2535 - 2557
Web of Science type
Article
Web of Science id
000289480700014
JCR category
ENGINEERING, BIOMEDICAL
JCR impact factor
2.829 (2011)
JCR rank
14/72 (2011)
JCR quartile
1 (2011)
ISSN
0031-9155
DOI
10.1088/0031-9155/56/8/013
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1228518
handle
http://hdl.handle.net/1854/LU-1228518
date created
2011-05-20 14:06:46
date last changed
2011-05-20 15:06:02
@article{1228518,
  abstract     = {In (FMRI)-F-19 oximetry, a method used to image tumour hypoxia, perfluorocarbons serve as oxygenation markers. The goal of this study is to evaluate the impact of perfluorocarbon distribution and concentration in (FMRI)-F-19 oximetry through a computer simulation. The simulation studies the correspondence between F-19 measured (pO(2)(FNMR)) and actual tissue oxygen tension (pO(2)) for several tissue perfluorocarbon distributions. For this, a Krogh tissue model is implemented which incorporates the presence of perfluorocarbons in blood and tissue. That is, in tissue the perfluorocarbons are distributed homogeneously according to Gaussian diffusion profiles, or the perfluorocarbons are concentrated in the capillary wall. Using these distributions, the oxygen tension in the simulation volume is calculated. The simulated mean oxygen tension is then compared with pO(2)(FNMR), the F-19 MRI-based measure of pO(2) and with pO(2)(0), pO(2) in the absence of perfluorocarbons. The agreement between pO(2)(FNMR) and actual pO(2) is influenced by vascular density and perfluorocarbon distribution. The presence of perfluorocarbons generally gives rise to a pO(2) increase in tissue. This effect is enhanced when perfluorocarbons are also present in blood. Only the homogeneous perfluorocarbon distribution in tissue with no perfluorocarbons in blood guarantees small deviations of pO(2)(FNMR) from pO(2). Hence, perfluorocarbon distribution in tissue and blood has a serious impact on the reliability of F-19 MRI-based measures of oxygen tension. In addition, the presence of perfluorocarbons influences the actual oxygen tension. This finding may be of great importance for further development of F-19 MRI oximetry.},
  author       = {Baete, Steven and Vandecasteele, Jan and De Deene, Yves},
  issn         = {0031-9155},
  journal      = {PHYSICS IN MEDICINE AND BIOLOGY},
  keyword      = {MARROW HEMATOPOIETIC COMPARTMENT,MODELING PO(2) DISTRIBUTIONS,MULTICELLULAR TUMOR SPHEROIDS,CELLULAR-AUTOMATON MODEL,MAGNETIC-RESONANCE,OXYGEN-TRANSPORT,TISSUE OXYGENATION,THEORETICAL SIMULATION,RESPIRATORY CHALLENGE,EMULSION MIXTURES},
  language     = {eng},
  number       = {8},
  pages        = {2535--2557},
  title        = {19F MRI oximetry: simulation of perfluorocarbon distribution impact},
  url          = {http://dx.doi.org/10.1088/0031-9155/56/8/013},
  volume       = {56},
  year         = {2011},
}

Chicago
Baete, Steven, Jan Vandecasteele, and Yves De Deene. 2011. “19F MRI Oximetry: Simulation of Perfluorocarbon Distribution Impact.” Physics in Medicine and Biology 56 (8): 2535–2557.
APA
Baete, S., Vandecasteele, J., & De Deene, Y. (2011). 19F MRI oximetry: simulation of perfluorocarbon distribution impact. PHYSICS IN MEDICINE AND BIOLOGY, 56(8), 2535–2557.
Vancouver
1.
Baete S, Vandecasteele J, De Deene Y. 19F MRI oximetry: simulation of perfluorocarbon distribution impact. PHYSICS IN MEDICINE AND BIOLOGY. 2011;56(8):2535–57.
MLA
Baete, Steven, Jan Vandecasteele, and Yves De Deene. “19F MRI Oximetry: Simulation of Perfluorocarbon Distribution Impact.” PHYSICS IN MEDICINE AND BIOLOGY 56.8 (2011): 2535–2557. Print.