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Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation

Tine Wyckhuys UGent, Paul Boon UGent, Robrecht Raedt UGent, Bregt Van Nieuwenhuyse UGent, Kristl Vonck UGent and Wytse Wadman UGent (2010) EPILEPSIA. 51(11). p.2297-2304
abstract
Purpose: Hippocampal deep brain stimulation (DBS) is an experimental therapy for patients with pharmacoresistant temporal lobe epilepsy (TLE). Despite the successful clinical application of DBS, the optimal stimulation parameters are undetermined. We evaluate the efficacy of a new form of DBS, using continuous stimuli with Poisson distributed intervals (Poisson distributed stimulation, PDS) in the kainate (KA) rat model, a validated model for human TLE. Methods: Status epilepticus was elicited by injection of KA (i.p.). After development of spontaneous seizures, rats were implanted with hippocampal DBS- and depth electroencephalography (EEG) electrodes. After baseline EEG monitoring, one group of rats (n = 13) was treated with PDS and a second (n = 11) received regular high frequency stimulation (HFS) at 130 Hz. Stimulation intensity was 100 mu A below the threshold for induction of epileptiform EEG activity. Results: Stimulation intensity was significantly lower for PDS (156 +/- 20 mu A) than HFS (207 +/- 23 mu A; p < 0.02). Seven (54%) of 13 rats treated with PDS and 5 (45%) of 11 rats treated with HFS experienced a significant reduction in seizure frequency. In PDS-improved rats, seizure frequency was reduced to 33% (p < 0.01) of baseline value and in HFS-improved rats to 50% (p < 0.01). After termination of PDS, seizure rate returned to baseline value. Discussion: Continuous hippocampal PDS significantly reduces the number of spontaneous seizures. Compared to regular HFS, there is a slightly larger number of improved rats and a larger efficacy at a considerably lower stimulus intensity. The first two observations leave room for optimization, whereas a lower intensity is beneficial for battery life.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SPONTANEOUS MOTOR SEIZURES, LONG-TERM POTENTIATION, TEMPORAL-LOBE EPILEPSY, DEEP BRAIN-STIMULATION, Hippocampus, Deep brain stimulation, Temporal lobe epilepsy, ELECTRICAL-STIMULATION, MODEL, PLASTICITY
journal title
EPILEPSIA
Epilepsia
volume
51
issue
11
pages
2297 - 2304
Web of Science type
Article
Web of Science id
000283595400010
JCR category
CLINICAL NEUROLOGY
JCR impact factor
3.955 (2010)
JCR rank
32/185 (2010)
JCR quartile
1 (2010)
ISSN
0013-9580
DOI
10.1111/j.1528-1167.2010.02750.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1228380
handle
http://hdl.handle.net/1854/LU-1228380
date created
2011-05-20 12:19:00
date last changed
2011-05-20 14:30:09
@article{1228380,
  abstract     = {Purpose: Hippocampal deep brain stimulation (DBS) is an experimental therapy for patients with pharmacoresistant temporal lobe epilepsy (TLE). Despite the successful clinical application of DBS, the optimal stimulation parameters are undetermined. We evaluate the efficacy of a new form of DBS, using continuous stimuli with Poisson distributed intervals (Poisson distributed stimulation, PDS) in the kainate (KA) rat model, a validated model for human TLE.
Methods: Status epilepticus was elicited by injection of KA (i.p.). After development of spontaneous seizures, rats were implanted with hippocampal DBS- and depth electroencephalography (EEG) electrodes. After baseline EEG monitoring, one group of rats (n = 13) was treated with PDS and a second (n = 11) received regular high frequency stimulation (HFS) at 130 Hz. Stimulation intensity was 100 mu A below the threshold for induction of epileptiform EEG activity.
Results: Stimulation intensity was significantly lower for PDS (156 +/- 20 mu A) than HFS (207 +/- 23 mu A; p {\textlangle} 0.02). Seven (54\%) of 13 rats treated with PDS and 5 (45\%) of 11 rats treated with HFS experienced a significant reduction in seizure frequency. In PDS-improved rats, seizure frequency was reduced to 33\% (p {\textlangle} 0.01) of baseline value and in HFS-improved rats to 50\% (p {\textlangle} 0.01). After termination of PDS, seizure rate returned to baseline value.
Discussion: Continuous hippocampal PDS significantly reduces the number of spontaneous seizures. Compared to regular HFS, there is a slightly larger number of improved rats and a larger efficacy at a considerably lower stimulus intensity. The first two observations leave room for optimization, whereas a lower intensity is beneficial for battery life.},
  author       = {Wyckhuys, Tine and Boon, Paul and Raedt, Robrecht and Van Nieuwenhuyse, Bregt and Vonck, Kristl and Wadman, Wytse},
  issn         = {0013-9580},
  journal      = {EPILEPSIA},
  keyword      = {SPONTANEOUS MOTOR SEIZURES,LONG-TERM POTENTIATION,TEMPORAL-LOBE EPILEPSY,DEEP BRAIN-STIMULATION,Hippocampus,Deep brain stimulation,Temporal lobe epilepsy,ELECTRICAL-STIMULATION,MODEL,PLASTICITY},
  language     = {eng},
  number       = {11},
  pages        = {2297--2304},
  title        = {Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation},
  url          = {http://dx.doi.org/10.1111/j.1528-1167.2010.02750.x},
  volume       = {51},
  year         = {2010},
}

Chicago
Wyckhuys, Tine, Paul Boon, Robrecht Raedt, Bregt Van Nieuwenhuyse, Kristl Vonck, and Wytse Wadman. 2010. “Suppression of Hippocampal Epileptic Seizures in the Kainate Rat by Poisson Distributed Stimulation.” Epilepsia 51 (11): 2297–2304.
APA
Wyckhuys, T., Boon, P., Raedt, R., Van Nieuwenhuyse, B., Vonck, K., & Wadman, W. (2010). Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation. EPILEPSIA, 51(11), 2297–2304.
Vancouver
1.
Wyckhuys T, Boon P, Raedt R, Van Nieuwenhuyse B, Vonck K, Wadman W. Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation. EPILEPSIA. 2010;51(11):2297–304.
MLA
Wyckhuys, Tine, Paul Boon, Robrecht Raedt, et al. “Suppression of Hippocampal Epileptic Seizures in the Kainate Rat by Poisson Distributed Stimulation.” EPILEPSIA 51.11 (2010): 2297–2304. Print.