Ghent University Academic Bibliography

Advanced

Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model

Robrecht Raedt UGent, Ralf Clinckers, Lies Mollet UGent, Kristl Vonck UGent, RIEM EL TAHRY UGent, Tine Wyckhuys UGent, Veerle De Herdt UGent, Evelien Carrette UGent, Wyste Wadman and Yvette Michotte, et al. (2011) JOURNAL OF NEUROCHEMISTRY. 117(3). p.461-469
abstract
>Vagus nerve stimulation (VNS) is an effective adjunctive treatment for medically refractory epilepsy. In this study, we measured VNS-induced changes in hippocampal neurotransmitter levels and determined their potential involvement in the anticonvulsive action of VNS, to elucidate the mechanism of action responsible for the seizure suppressing effect of VNS in an animal model for limbic seizures. We used in vivo intracerebral microdialysis to measure VNS-induced changes in hippocampal extracellular concentrations of noradrenaline, dopamine, serotonin and GABA in freely moving, male Wistar rats. During the same experiment, the effect of VNS on pilocarpine-induced limbic seizures was assessed using video-EEG monitoring. The involvement of VNS-induced increases in hippocampal noradrenaline in the mechanims of action of VNS was evaluated by blocking hippocampal alpha(2)-receptors. VNS produced a significant increase in hippocampal noradrenaline concentration (69 +/- 16% above baseline levels). VNS also increased the latency between pilocarpine infusion and the onset of epileptiform discharges, and reduced the duration and severity of pilocarpine-induced limbic seizures. A strong positive correlation was found between the noradrenergic and anticonvulsive effects of VNS. Blockade of hippocampal alpha(2)-receptors reversed the seizure-suppressing effect of VNS. VNS induces increases in extracellular hippocampal noradrenaline, which are at least partly responsible for its seizure-suppressing effect in a model for limbic seizures, and constitute a potential biomarker for the efficacy of VNS in temporal lobe epilepsy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
REFRACTORY EPILEPSY, LOCUS-CERULEUS GRAFTS, NORADRENERGIC TRANSMISSION, FREELY MOVING RATS, PILOCARPINE-INDUCED SEIZURES, vagus nerve stimulation, pilocarpine, temporal lobe epilepsy, KINDLING EPILEPSY, AMINO-ACIDS, BRAIN-STEM, NOREPINEPHRINE, COERULEUS, EEG, Hippocampus, noradrenaline
journal title
JOURNAL OF NEUROCHEMISTRY
J. Neurochem.
volume
117
issue
3
pages
461 - 469
Web of Science type
Article
Web of Science id
000289464500010
JCR category
NEUROSCIENCES
JCR impact factor
4.061 (2011)
JCR rank
59/242 (2011)
JCR quartile
1 (2011)
ISSN
0022-3042
DOI
10.1111/j.1471-4159.2011.07214.x
project
The integrative neuroscience of behavioral control (Neuroscience)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1228308
handle
http://hdl.handle.net/1854/LU-1228308
date created
2011-05-20 12:00:35
date last changed
2013-02-27 09:05:56
@article{1228308,
  abstract     = {{\textrangle}Vagus nerve stimulation (VNS) is an effective adjunctive treatment for medically refractory epilepsy. In this study, we measured VNS-induced changes in hippocampal neurotransmitter levels and determined their potential involvement in the anticonvulsive action of VNS, to elucidate the mechanism of action responsible for the seizure suppressing effect of VNS in an animal model for limbic seizures. We used in vivo intracerebral microdialysis to measure VNS-induced changes in hippocampal extracellular concentrations of noradrenaline, dopamine, serotonin and GABA in freely moving, male Wistar rats. During the same experiment, the effect of VNS on pilocarpine-induced limbic seizures was assessed using video-EEG monitoring. The involvement of VNS-induced increases in hippocampal noradrenaline in the mechanims of action of VNS was evaluated by blocking hippocampal alpha(2)-receptors. VNS produced a significant increase in hippocampal noradrenaline concentration (69 +/- 16\% above baseline levels). VNS also increased the latency between pilocarpine infusion and the onset of epileptiform discharges, and reduced the duration and severity of pilocarpine-induced limbic seizures. A strong positive correlation was found between the noradrenergic and anticonvulsive effects of VNS. Blockade of hippocampal alpha(2)-receptors reversed the seizure-suppressing effect of VNS. VNS induces increases in extracellular hippocampal noradrenaline, which are at least partly responsible for its seizure-suppressing effect in a model for limbic seizures, and constitute a potential biomarker for the efficacy of VNS in temporal lobe epilepsy.},
  author       = {Raedt, Robrecht and Clinckers, Ralf and Mollet, Lies and Vonck, Kristl and EL TAHRY, RIEM and Wyckhuys, Tine and De Herdt, Veerle and Carrette, Evelien and Wadman, Wyste and Michotte, Yvette and Smolders, Ilse and Boon, Paul and Meurs, Alfred},
  issn         = {0022-3042},
  journal      = {JOURNAL OF NEUROCHEMISTRY},
  keyword      = {REFRACTORY EPILEPSY,LOCUS-CERULEUS GRAFTS,NORADRENERGIC TRANSMISSION,FREELY MOVING RATS,PILOCARPINE-INDUCED SEIZURES,vagus nerve stimulation,pilocarpine,temporal lobe epilepsy,KINDLING EPILEPSY,AMINO-ACIDS,BRAIN-STEM,NOREPINEPHRINE,COERULEUS,EEG,Hippocampus,noradrenaline},
  language     = {eng},
  number       = {3},
  pages        = {461--469},
  title        = {Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model},
  url          = {http://dx.doi.org/10.1111/j.1471-4159.2011.07214.x},
  volume       = {117},
  year         = {2011},
}

Chicago
Raedt, Robrecht, Ralf Clinckers, Lies Mollet, Kristl Vonck, RIEM EL TAHRY, Tine Wyckhuys, VEERLE DE HERDT, et al. 2011. “Increased Hippocampal Noradrenaline Is a Biomarker for Efficacy of Vagus Nerve Stimulation in a Limbic Seizure Model.” Journal of Neurochemistry 117 (3): 461–469.
APA
Raedt, Robrecht, Clinckers, R., Mollet, L., Vonck, K., EL TAHRY, R., Wyckhuys, T., DE HERDT, V., et al. (2011). Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model. JOURNAL OF NEUROCHEMISTRY, 117(3), 461–469.
Vancouver
1.
Raedt R, Clinckers R, Mollet L, Vonck K, EL TAHRY R, Wyckhuys T, et al. Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model. JOURNAL OF NEUROCHEMISTRY. 2011;117(3):461–9.
MLA
Raedt, Robrecht, Ralf Clinckers, Lies Mollet, et al. “Increased Hippocampal Noradrenaline Is a Biomarker for Efficacy of Vagus Nerve Stimulation in a Limbic Seizure Model.” JOURNAL OF NEUROCHEMISTRY 117.3 (2011): 461–469. Print.