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Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion

(2011) IMMUNITY. 34(1). p.108-121
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Abstract
Although a fraction of human blood memory CD4(+) T cells expresses chemokine (C-X-C motif) receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established. Here we show that human blood CXCR5(+)CD4(+) T cells share functional properties with Tfh cells and appear to represent their circulating memory compartment. Blood CXCR5(+)CD4(+) T cells comprised three subsets: T helper 1 (Th1), Th2, and Th17 cells. Th2 and Th17 cells within CXCR5(+), but not within CXCR5(-), compartment efficiently induced naive B cells to produce immunoglobulins via interleukin-21 (IL-21). In contrast, Th1 cells from both CXCR5(+) and CXCR5(-) compartments lacked the capacity to help B cells. Patients with juvenile dermatomyositis, a systemic autoimmune disease, displayed a profound skewing of blood CXCR5(+) Th cell subsets toward Th2 and Th17 cells. Importantly, the skewing of subsets correlated with disease activity and frequency of blood plasmablasts. Collectively, our study suggests that an altered balance of Tfh cell subsets contributes to human autoimmunity.
Keywords
CHEMOKINE RECEPTOR EXPRESSION, RESPONSES, SYSTEMIC-LUPUS-ERYTHEMATOSUS, HELPER MEMORY CELLS, HUMAN TH17 CELLS, B-CELLS, GENE-EXPRESSION, DENDRITIC CELLS, IL-21, CUTTING EDGE

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MLA
Morita, Rimpei, Nathalie Schmitt, Salah-Eddine Bentebibel, et al. “Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets That Differentially Support Antibody Secretion.” IMMUNITY 34.1 (2011): 108–121. Print.
APA
Morita, R., Schmitt, N., Bentebibel, S.-E., Ranganathan, R., Bourdery, L., Zurawski, G., Foucat, E., et al. (2011). Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. IMMUNITY, 34(1), 108–121.
Chicago author-date
Morita, Rimpei, Nathalie Schmitt, Salah-Eddine Bentebibel, Rajaram Ranganathan, Laure Bourdery, Gerard Zurawski, Emile Foucat, et al. 2011. “Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets That Differentially Support Antibody Secretion.” Immunity 34 (1): 108–121.
Chicago author-date (all authors)
Morita, Rimpei, Nathalie Schmitt, Salah-Eddine Bentebibel, Rajaram Ranganathan, Laure Bourdery, Gerard Zurawski, Emile Foucat, Melissa Dullaers, SangKon Oh, Nathalie Sabzghabaei, Elizabeth M Lavecchio, Marilynn Punaro, Virginia Pascual-Madorran, Jacques Banchereau, and Hideki Ueno. 2011. “Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets That Differentially Support Antibody Secretion.” Immunity 34 (1): 108–121.
Vancouver
1.
Morita R, Schmitt N, Bentebibel S-E, Ranganathan R, Bourdery L, Zurawski G, et al. Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. IMMUNITY. 2011;34(1):108–21.
IEEE
[1]
R. Morita et al., “Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion,” IMMUNITY, vol. 34, no. 1, pp. 108–121, 2011.
@article{1227911,
  abstract     = {Although a fraction of human blood memory CD4(+) T cells expresses chemokine (C-X-C motif) receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established. Here we show that human blood CXCR5(+)CD4(+) T cells share functional properties with Tfh cells and appear to represent their circulating memory compartment. Blood CXCR5(+)CD4(+) T cells comprised three subsets: T helper 1 (Th1), Th2, and Th17 cells. Th2 and Th17 cells within CXCR5(+), but not within CXCR5(-), compartment efficiently induced naive B cells to produce immunoglobulins via interleukin-21 (IL-21). In contrast, Th1 cells from both CXCR5(+) and CXCR5(-) compartments lacked the capacity to help B cells. Patients with juvenile dermatomyositis, a systemic autoimmune disease, displayed a profound skewing of blood CXCR5(+) Th cell subsets toward Th2 and Th17 cells. Importantly, the skewing of subsets correlated with disease activity and frequency of blood plasmablasts. Collectively, our study suggests that an altered balance of Tfh cell subsets contributes to human autoimmunity.},
  author       = {Morita, Rimpei and Schmitt, Nathalie and Bentebibel, Salah-Eddine and Ranganathan, Rajaram and Bourdery, Laure and Zurawski, Gerard and Foucat, Emile and Dullaers, Melissa and Oh, SangKon and Sabzghabaei, Nathalie and Lavecchio, Elizabeth M and Punaro, Marilynn and Pascual-Madorran, Virginia and Banchereau, Jacques and Ueno, Hideki},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keywords     = {CHEMOKINE RECEPTOR EXPRESSION,RESPONSES,SYSTEMIC-LUPUS-ERYTHEMATOSUS,HELPER MEMORY CELLS,HUMAN TH17 CELLS,B-CELLS,GENE-EXPRESSION,DENDRITIC CELLS,IL-21,CUTTING EDGE},
  language     = {eng},
  number       = {1},
  pages        = {108--121},
  title        = {Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion},
  url          = {http://dx.doi.org/10.1016/j.immuni.2010.12.012},
  volume       = {34},
  year         = {2011},
}

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