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The potential of Macrostomum lignano to recover from γ-ray irradiation

Katrien De Mulder (UGent) , Georg Kuales, Daniela Pfister, Bernhard Egger, Thomas Seppi, Paul Eichberger, Gaetan Borgonie (UGent) and Peter Ladurner
(2010) CELL AND TISSUE RESEARCH. 339(3). p.527-542
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Abstract
Stem cells are the only proliferating cells in flatworms and can be eliminated by irradiation with no damage to differentiated cells. We investigated the effect of fractionated irradiation schemes on Macrostomum lignano, namely, on survival, gene expression, morphology and regeneration. Proliferating cells were almost undetectable during the first week post-treatment. Cell proliferation and gene expression were restored within 1 month in a dose-dependent manner following exposure to up to 150 Gy irradiation. During recovery, stem cells did not cross the midline but were restricted within lateral compartments. An accumulated dose of 210 Gy resulted in a lethal phenotype. Our findings demonstrate that M. lignano represents a suitable model system for elucidating the effect of irradiation on the stem cell system in flatworms and for improving our understanding of the recovery potential of severely damaged stem-cell systems.
Keywords
STEM-CELL MAINTENANCE, Macrostomum lignano (Platyhelminthes), IONIZING-RADIATION, PLANARIAN MIDLINE, REGENERATION, GENE, PLATYHELMINTHES, EXPRESSION, NEOBLASTS, DIFFERENTIATION, RHABDITOPHORA, Flatworm, Planaria, Irradiation, Stem cells

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MLA
De Mulder, Katrien, et al. “The Potential of Macrostomum Lignano to Recover from γ-Ray Irradiation.” CELL AND TISSUE RESEARCH, vol. 339, no. 3, 2010, pp. 527–42, doi:10.1007/s00441-009-0915-6.
APA
De Mulder, K., Kuales, G., Pfister, D., Egger, B., Seppi, T., Eichberger, P., … Ladurner, P. (2010). The potential of Macrostomum lignano to recover from γ-ray irradiation. CELL AND TISSUE RESEARCH, 339(3), 527–542. https://doi.org/10.1007/s00441-009-0915-6
Chicago author-date
De Mulder, Katrien, Georg Kuales, Daniela Pfister, Bernhard Egger, Thomas Seppi, Paul Eichberger, Gaetan Borgonie, and Peter Ladurner. 2010. “The Potential of Macrostomum Lignano to Recover from γ-Ray Irradiation.” CELL AND TISSUE RESEARCH 339 (3): 527–42. https://doi.org/10.1007/s00441-009-0915-6.
Chicago author-date (all authors)
De Mulder, Katrien, Georg Kuales, Daniela Pfister, Bernhard Egger, Thomas Seppi, Paul Eichberger, Gaetan Borgonie, and Peter Ladurner. 2010. “The Potential of Macrostomum Lignano to Recover from γ-Ray Irradiation.” CELL AND TISSUE RESEARCH 339 (3): 527–542. doi:10.1007/s00441-009-0915-6.
Vancouver
1.
De Mulder K, Kuales G, Pfister D, Egger B, Seppi T, Eichberger P, et al. The potential of Macrostomum lignano to recover from γ-ray irradiation. CELL AND TISSUE RESEARCH. 2010;339(3):527–42.
IEEE
[1]
K. De Mulder et al., “The potential of Macrostomum lignano to recover from γ-ray irradiation,” CELL AND TISSUE RESEARCH, vol. 339, no. 3, pp. 527–542, 2010.
@article{1227714,
  abstract     = {{Stem cells are the only proliferating cells in flatworms and can be eliminated by irradiation with no damage to differentiated cells. We investigated the effect of fractionated irradiation schemes on Macrostomum lignano, namely, on survival, gene expression, morphology and regeneration. Proliferating cells were almost undetectable during the first week post-treatment. Cell proliferation and gene expression were restored within 1 month in a dose-dependent manner following exposure to up to 150 Gy irradiation. During recovery, stem cells did not cross the midline but were restricted within lateral compartments. An accumulated dose of 210 Gy resulted in a lethal phenotype. Our findings demonstrate that M. lignano represents a suitable model system for elucidating the effect of irradiation on the stem cell system in flatworms and for improving our understanding of the recovery potential of severely damaged stem-cell systems.}},
  author       = {{De Mulder, Katrien and Kuales, Georg and Pfister, Daniela and Egger, Bernhard and Seppi, Thomas and Eichberger, Paul and Borgonie, Gaetan and Ladurner, Peter}},
  issn         = {{0302-766X}},
  journal      = {{CELL AND TISSUE RESEARCH}},
  keywords     = {{STEM-CELL MAINTENANCE,Macrostomum lignano (Platyhelminthes),IONIZING-RADIATION,PLANARIAN MIDLINE,REGENERATION,GENE,PLATYHELMINTHES,EXPRESSION,NEOBLASTS,DIFFERENTIATION,RHABDITOPHORA,Flatworm,Planaria,Irradiation,Stem cells}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{527--542}},
  title        = {{The potential of Macrostomum lignano to recover from γ-ray irradiation}},
  url          = {{http://doi.org/10.1007/s00441-009-0915-6}},
  volume       = {{339}},
  year         = {{2010}},
}
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