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Designing oral vaccines targeting intestinal dendritic cells

Bert Devriendt (UGent) , Bruno De Geest (UGent) and Eric Cox (UGent)
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Abstract
Areas covered: In this review, current knowledge on dendritic cell subsets is discussed, along with progress in the development of selective antigen targeting to these cells, in addition to focusing on data obtained in mice and, where possible, the pig, as a non-rodent animal model for humans. Moreover, the potential use and benefits of Fc gamma gamma receptor-mediated targeting of antigen delivery systems are highlighted. Expert opinion: In conclusion, dendritic cell targeting ligands grafted on antigen carrier systems should preferably bind to a conserved endocytotic receptor, facilitating the design of a multispecies vaccine platform, which could elicit robust protective immune responses against enteric pathogens.
Keywords
FOLLICLE-ASSOCIATED EPITHELIUM, FC-GAMMA RECEPTOR, MUCOSAL IMMUNE-RESPONSES, ANTIGEN-PRESENTING CELLS, MESENTERIC LYMPH-NODES, TRANS-RETINOIC ACID, REGULATORY T-CELLS, C-TYPE LECTIN, IN-VIVO, PEYERS PATCH

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Citation

Please use this url to cite or link to this publication:

Chicago
Devriendt, Bert, Bruno De Geest, and Eric Cox. 2011. “Designing Oral Vaccines Targeting Intestinal Dendritic Cells.” Expert Opinion on Drug Delivery 8 (4): 467–483.
APA
Devriendt, B., De Geest, B., & Cox, E. (2011). Designing oral vaccines targeting intestinal dendritic cells. EXPERT OPINION ON DRUG DELIVERY, 8(4), 467–483.
Vancouver
1.
Devriendt B, De Geest B, Cox E. Designing oral vaccines targeting intestinal dendritic cells. EXPERT OPINION ON DRUG DELIVERY. 2011;8(4):467–83.
MLA
Devriendt, Bert, Bruno De Geest, and Eric Cox. “Designing Oral Vaccines Targeting Intestinal Dendritic Cells.” EXPERT OPINION ON DRUG DELIVERY 8.4 (2011): 467–483. Print.
@article{1227231,
  abstract     = {Areas covered: In this review, current knowledge on dendritic cell subsets is discussed, along with progress in the development of selective antigen targeting to these cells, in addition to focusing on data obtained in mice and, where possible, the pig, as a non-rodent animal model for humans. Moreover, the potential use and benefits of Fc gamma gamma receptor-mediated targeting of antigen delivery systems are highlighted.
Expert opinion: In conclusion, dendritic cell targeting ligands grafted on antigen carrier systems should preferably bind to a conserved endocytotic receptor, facilitating the design of a multispecies vaccine platform, which could elicit robust protective immune responses against enteric pathogens.},
  author       = {Devriendt, Bert and De Geest, Bruno and Cox, Eric},
  issn         = {1742-5247},
  journal      = {EXPERT OPINION ON DRUG DELIVERY},
  keyword      = {FOLLICLE-ASSOCIATED EPITHELIUM,FC-GAMMA RECEPTOR,MUCOSAL IMMUNE-RESPONSES,ANTIGEN-PRESENTING CELLS,MESENTERIC LYMPH-NODES,TRANS-RETINOIC ACID,REGULATORY T-CELLS,C-TYPE LECTIN,IN-VIVO,PEYERS PATCH},
  language     = {eng},
  number       = {4},
  pages        = {467--483},
  title        = {Designing oral vaccines targeting intestinal dendritic cells},
  url          = {http://dx.doi.org/10.1517/17425247.2011.561312},
  volume       = {8},
  year         = {2011},
}

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