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Propionate as a health-promoting microbial metabolite in the human gut

Elham Hosseini UGent, Charlotte Grootaert UGent, Willy Verstraete UGent and Tom Van de Wiele UGent (2011) NUTRITION REVIEWS. 69(5). p.245-258
abstract
Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues. Steering microbial propionate production through diet could therefore be a potent strategy to increase health effects from microbial carbohydrate fermentation. The present review first discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to produce propionate. Second, it evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionate. Third, given the complexity of the gut microbiota, propionate production is approached from a microbial-ecological perspective that includes interaction processes such as cross-feeding mechanisms. Finally, it introduces the development of functional gene-based analytical tools to detect and characterize propionate-producing microorganisms in a complex community. The information in this review may be helpful for designing functional food strategies that aim to promote propionate-associated health benefits.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
obesity, gastrointestinal, colon, cancer, propionic acid, satiety, CHAIN FATTY-ACIDS, INCREASES SERUM PROPIONATE, 16S RIBOSOMAL-RNA, REAL-TIME PCR, LIPID-METABOLISM, IN-VITRO, SELENOMONAS-RUMINANTIUM, MEGASPHAERA-ELSDENII, WHEAT BRAN, BACTEROIDES-FRAGILIS
journal title
NUTRITION REVIEWS
Nutr. Rev.
volume
69
issue
5
pages
245 - 258
Web of Science type
Review
Web of Science id
000289892100001
JCR category
NUTRITION & DIETETICS
JCR impact factor
4.472 (2011)
JCR rank
7/71 (2011)
JCR quartile
1 (2011)
ISSN
0029-6643
DOI
10.1111/j.1753-4887.2011.00388.x
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1226164
handle
http://hdl.handle.net/1854/LU-1226164
date created
2011-05-18 11:47:22
date last changed
2013-02-27 12:08:08
@article{1226164,
  abstract     = {Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues. Steering microbial propionate production through diet could therefore be a potent strategy to increase health effects from microbial carbohydrate fermentation. The present review first discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to produce propionate. Second, it evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionate. Third, given the complexity of the gut microbiota, propionate production is approached from a microbial-ecological perspective that includes interaction processes such as cross-feeding mechanisms. Finally, it introduces the development of functional gene-based analytical tools to detect and characterize propionate-producing microorganisms in a complex community. The information in this review may be helpful for designing functional food strategies that aim to promote propionate-associated health benefits.},
  author       = {Hosseini, Elham and Grootaert, Charlotte and Verstraete, Willy and Van de Wiele, Tom},
  issn         = {0029-6643},
  journal      = {NUTRITION REVIEWS},
  keyword      = {obesity,gastrointestinal,colon,cancer,propionic acid,satiety,CHAIN FATTY-ACIDS,INCREASES SERUM PROPIONATE,16S RIBOSOMAL-RNA,REAL-TIME PCR,LIPID-METABOLISM,IN-VITRO,SELENOMONAS-RUMINANTIUM,MEGASPHAERA-ELSDENII,WHEAT BRAN,BACTEROIDES-FRAGILIS},
  language     = {eng},
  number       = {5},
  pages        = {245--258},
  title        = {Propionate as a health-promoting microbial metabolite in the human gut},
  url          = {http://dx.doi.org/10.1111/j.1753-4887.2011.00388.x},
  volume       = {69},
  year         = {2011},
}

Chicago
Hosseini, Elham, Charlotte Grootaert, Willy Verstraete, and Tom Van de Wiele. 2011. “Propionate as a Health-promoting Microbial Metabolite in the Human Gut.” Nutrition Reviews 69 (5): 245–258.
APA
Hosseini, E., Grootaert, C., Verstraete, W., & Van de Wiele, T. (2011). Propionate as a health-promoting microbial metabolite in the human gut. NUTRITION REVIEWS, 69(5), 245–258.
Vancouver
1.
Hosseini E, Grootaert C, Verstraete W, Van de Wiele T. Propionate as a health-promoting microbial metabolite in the human gut. NUTRITION REVIEWS. 2011;69(5):245–58.
MLA
Hosseini, Elham, Charlotte Grootaert, Willy Verstraete, et al. “Propionate as a Health-promoting Microbial Metabolite in the Human Gut.” NUTRITION REVIEWS 69.5 (2011): 245–258. Print.