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Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) TRENDS IN IMMUNOLOGY. 32(4). p.157-164
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These molecules are recognized by the innate immune system by pattern recognition receptors the same receptors that detect pathogen-associated molecular patterns, thus revealing similarities between pathogen-induced and non-infectious inflammatory responses. Many DAMPs are derived from the plasma membrane, nucleus, endoplasmic reticulum and cytosol. Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondria! DAMPs and discuss their contribution to inflammation and development of human pathologies.
Keywords
NECROTIC CELL-DEATH, APOPTOSIS, FIND-ME SIGNAL, CYTOCHROME-C, IN-VIVO, EXTRACELLULAR ATP, OXIDATIVE STRESS, PROTEIN-COUPLED RECEPTORS, INNATE IMMUNE-RESPONSES, FORMYL PEPTIDE RECEPTORS

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Chicago
Krysko, Dmitri, Patrizia Agostinis, Olga Krysko, Abhishek D Garg, Claus Bachert, Bart Lambrecht, and Peter Vandenabeele. 2011. “Emerging Role of Damage-associated Molecular Patterns Derived from Mitochondria in Inflammation.” Trends in Immunology 32 (4): 157–164.
APA
Krysko, Dmitri, Agostinis, P., Krysko, O., Garg, A. D., Bachert, C., Lambrecht, B., & Vandenabeele, P. (2011). Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. TRENDS IN IMMUNOLOGY, 32(4), 157–164.
Vancouver
1.
Krysko D, Agostinis P, Krysko O, Garg AD, Bachert C, Lambrecht B, et al. Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. TRENDS IN IMMUNOLOGY. 2011;32(4):157–64.
MLA
Krysko, Dmitri, Patrizia Agostinis, Olga Krysko, et al. “Emerging Role of Damage-associated Molecular Patterns Derived from Mitochondria in Inflammation.” TRENDS IN IMMUNOLOGY 32.4 (2011): 157–164. Print.
@article{1224403,
  abstract     = {Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These molecules are recognized by the innate immune system by pattern recognition receptors the same receptors that detect pathogen-associated molecular patterns, thus revealing similarities between pathogen-induced and non-infectious inflammatory responses. Many DAMPs are derived from the plasma membrane, nucleus, endoplasmic reticulum and cytosol. Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondria! DAMPs and discuss their contribution to inflammation and development of human pathologies.},
  author       = {Krysko, Dmitri and Agostinis, Patrizia and Krysko, Olga and Garg, Abhishek D and Bachert, Claus and Lambrecht, Bart and Vandenabeele, Peter},
  issn         = {1471-4906},
  journal      = {TRENDS IN IMMUNOLOGY},
  keyword      = {NECROTIC CELL-DEATH,APOPTOSIS,FIND-ME SIGNAL,CYTOCHROME-C,IN-VIVO,EXTRACELLULAR ATP,OXIDATIVE STRESS,PROTEIN-COUPLED RECEPTORS,INNATE IMMUNE-RESPONSES,FORMYL PEPTIDE RECEPTORS},
  language     = {eng},
  number       = {4},
  pages        = {157--164},
  title        = {Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation},
  url          = {http://dx.doi.org/10.1016/j.it.2011.01.005},
  volume       = {32},
  year         = {2011},
}

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