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Donor haptoglobin phenotype determines outcome following liver transplantation

Reinhart Speeckaert UGent, Hans Van Vlierberghe UGent, Roberto Troisi UGent, Dirk De Bacquer UGent, MARIJN SPEECKAERT UGent, MARC DE BUYZERE UGent, Lutgarde Claeys, Bernard de Hemptinne UGent and Joris Delanghe UGent (2011) TRANSPLANT INTERNATIONAL. 24(6). p.619-626
abstract
Haptoglobin (Hp) is a polymorphic plasma protein with multiple functions defined by three major phenotypes (Hp 1-1, Hp 2-1, and Hp 2-2). In this article, the effects of the donor Hp phenotype (determined by starch gel electrophoresis) on the outcome and the iron status after liver transplantation were investigated. A total of 450 liver transplant patients were enrolled in this study with a median follow-up of 37 months. Kaplan-Meier and Cox regression survival analyses showed a significantly worse graft survival for liver transplantation cases with an Hp 2-2 donor phenotype, which was associated with an increased mortality rate in this group. In male patients, the Hp 2-2 phenotype was associated with higher serum ferritin concentrations, which may be linked to the significantly increased likelihood of infectious complications in this phenotype. Liver transplant patients with Hp 1-1 and Hp 2-1 grafts had a better outcome probability than recipients of an Hp 2-2 graft, which may be explained by differences in iron metabolism induced by the Hp genotype of the graft.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
graft survival, genetic polymorphism, haptoglobin, iron, liver transplantation, MODULATION, METABOLISM, IDENTIFICATION, PROTEINS, INFECTION, HEMOGLOBIN, IN-VITRO, HEPATITIS-C, GENE POLYMORPHISMS, IRON OVERLOAD, survival
journal title
TRANSPLANT INTERNATIONAL
Transpl. Int.
volume
24
issue
6
pages
619 - 626
Web of Science type
Article
Web of Science id
000289988400015
JCR category
SURGERY
JCR impact factor
2.921 (2011)
JCR rank
26/198 (2011)
JCR quartile
1 (2011)
ISSN
0934-0874
DOI
10.1111/j.1432-2277.2011.01246.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1222947
handle
http://hdl.handle.net/1854/LU-1222947
date created
2011-05-13 10:57:12
date last changed
2011-07-12 11:13:31
@article{1222947,
  abstract     = {Haptoglobin (Hp) is a polymorphic plasma protein with multiple functions defined by three major phenotypes (Hp 1-1, Hp 2-1, and Hp 2-2). In this article, the effects of the donor Hp phenotype (determined by starch gel electrophoresis) on the outcome and the iron status after liver transplantation were investigated. A total of 450 liver transplant patients were enrolled in this study with a median follow-up of 37 months. Kaplan-Meier and Cox regression survival analyses showed a significantly worse graft survival for liver transplantation cases with an Hp 2-2 donor phenotype, which was associated with an increased mortality rate in this group. In male patients, the Hp 2-2 phenotype was associated with higher serum ferritin concentrations, which may be linked to the significantly increased likelihood of infectious complications in this phenotype. Liver transplant patients with Hp 1-1 and Hp 2-1 grafts had a better outcome probability than recipients of an Hp 2-2 graft, which may be explained by differences in iron metabolism induced by the Hp genotype of the graft.},
  author       = {Speeckaert, Reinhart and Van Vlierberghe, Hans and Troisi, Roberto and De Bacquer, Dirk and SPEECKAERT, MARIJN and DE BUYZERE, MARC and Claeys, Lutgarde and de Hemptinne, Bernard and Delanghe, Joris},
  issn         = {0934-0874},
  journal      = {TRANSPLANT INTERNATIONAL},
  keyword      = {graft survival,genetic polymorphism,haptoglobin,iron,liver transplantation,MODULATION,METABOLISM,IDENTIFICATION,PROTEINS,INFECTION,HEMOGLOBIN,IN-VITRO,HEPATITIS-C,GENE POLYMORPHISMS,IRON OVERLOAD,survival},
  language     = {eng},
  number       = {6},
  pages        = {619--626},
  title        = {Donor haptoglobin phenotype determines outcome following liver transplantation},
  url          = {http://dx.doi.org/10.1111/j.1432-2277.2011.01246.x},
  volume       = {24},
  year         = {2011},
}

Chicago
Speeckaert, Reinhart, Hans Van Vlierberghe, Roberto Troisi, Dirk De Bacquer, MARIJN SPEECKAERT, Marc De Buyzere, Lutgarde Claeys, Bernard de Hemptinne, and Joris Delanghe. 2011. “Donor Haptoglobin Phenotype Determines Outcome Following Liver Transplantation.” Transplant International 24 (6): 619–626.
APA
Speeckaert, R., Van Vlierberghe, H., Troisi, R., De Bacquer, D., SPEECKAERT, M., De Buyzere, M., Claeys, L., et al. (2011). Donor haptoglobin phenotype determines outcome following liver transplantation. TRANSPLANT INTERNATIONAL, 24(6), 619–626.
Vancouver
1.
Speeckaert R, Van Vlierberghe H, Troisi R, De Bacquer D, SPEECKAERT M, De Buyzere M, et al. Donor haptoglobin phenotype determines outcome following liver transplantation. TRANSPLANT INTERNATIONAL. 2011;24(6):619–26.
MLA
Speeckaert, Reinhart, Hans Van Vlierberghe, Roberto Troisi, et al. “Donor Haptoglobin Phenotype Determines Outcome Following Liver Transplantation.” TRANSPLANT INTERNATIONAL 24.6 (2011): 619–626. Print.