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Enclosed volume determination of concentrated dioctadecyldimethylammonium chloride (DODAC) vesicular dispersions by low-resolution proton NMR diffusometry and T-2 relaxometry

Paolo Sabatino (UGent) , Pieter Saveyn (UGent) , José Martins (UGent) and Paul Van Der Meeren (UGent)
(2011) LANGMUIR. 27(8). p.4532-4540
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Abstract
The enclosed volume of concentrated dioctadecyldimethylammonium chloride (DODAC) dispersions has been determined by means of low-resolution NMR pfg-diffusometry and T-2 relaxometry. The pfg-NMR diffusometry method is based on the different diffusion behaviors of water in the external and internal phases and as such does not require the addition of a tracer. On the other hand, T-2 relaxometry is based on the different relaxation behaviors of water fractions upon addition of manganese chloride as external (paramagnetic) probe. It was noticed that reliable results are found only for temperatures below the phase transition temperature of DODAC, when the exchange between the two water compartments can be neglected. At 5 degrees C, these two independent methods resulted in similar enclosed volume values, meaning that the results are reliable and reflect the real enclosed volume. In addition, the T-2 relaxometry method has been proven to be useful in the investigation of the DODAC membrane permeability.
Keywords
SURFACTANTS, RELAXATION, EFFICIENCIES, LIPOSOMES, VESICLES, INTEGRAL-EQUATIONS, DIFFUSION, INTERNAL VOLUMES, RESONANCE, TRANSPORT

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Chicago
Sabatino, Paolo, Pieter Saveyn, José Martins, and Paul Van Der Meeren. 2011. “Enclosed Volume Determination of Concentrated Dioctadecyldimethylammonium Chloride (DODAC) Vesicular Dispersions by Low-resolution Proton NMR Diffusometry and T-2 Relaxometry.” Langmuir 27 (8): 4532–4540.
APA
Sabatino, P., Saveyn, P., Martins, J., & Van Der Meeren, P. (2011). Enclosed volume determination of concentrated dioctadecyldimethylammonium chloride (DODAC) vesicular dispersions by low-resolution proton NMR diffusometry and T-2 relaxometry. LANGMUIR, 27(8), 4532–4540.
Vancouver
1.
Sabatino P, Saveyn P, Martins J, Van Der Meeren P. Enclosed volume determination of concentrated dioctadecyldimethylammonium chloride (DODAC) vesicular dispersions by low-resolution proton NMR diffusometry and T-2 relaxometry. LANGMUIR. 2011;27(8):4532–40.
MLA
Sabatino, Paolo, Pieter Saveyn, José Martins, et al. “Enclosed Volume Determination of Concentrated Dioctadecyldimethylammonium Chloride (DODAC) Vesicular Dispersions by Low-resolution Proton NMR Diffusometry and T-2 Relaxometry.” LANGMUIR 27.8 (2011): 4532–4540. Print.
@article{1221232,
  abstract     = {The enclosed volume of concentrated dioctadecyldimethylammonium chloride (DODAC) dispersions has been determined by means of low-resolution NMR pfg-diffusometry and T-2 relaxometry. The pfg-NMR diffusometry method is based on the different diffusion behaviors of water in the external and internal phases and as such does not require the addition of a tracer. On the other hand, T-2 relaxometry is based on the different relaxation behaviors of water fractions upon addition of manganese chloride as external (paramagnetic) probe. It was noticed that reliable results are found only for temperatures below the phase transition temperature of DODAC, when the exchange between the two water compartments can be neglected. At 5 degrees C, these two independent methods resulted in similar enclosed volume values, meaning that the results are reliable and reflect the real enclosed volume. In addition, the T-2 relaxometry method has been proven to be useful in the investigation of the DODAC membrane permeability.},
  author       = {Sabatino, Paolo and Saveyn, Pieter and Martins, Jos{\'e} and Van Der Meeren, Paul},
  issn         = {0743-7463},
  journal      = {LANGMUIR},
  keyword      = {SURFACTANTS,RELAXATION,EFFICIENCIES,LIPOSOMES,VESICLES,INTEGRAL-EQUATIONS,DIFFUSION,INTERNAL VOLUMES,RESONANCE,TRANSPORT},
  language     = {eng},
  number       = {8},
  pages        = {4532--4540},
  title        = {Enclosed volume determination of concentrated dioctadecyldimethylammonium chloride (DODAC) vesicular dispersions by low-resolution proton NMR diffusometry and T-2 relaxometry},
  url          = {http://dx.doi.org/10.1021/la200327y},
  volume       = {27},
  year         = {2011},
}

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