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Epigenetics and its implications for ecotoxicology

Michiel Vandegehuchte UGent and Colin Janssen UGent (2011) ECOTOXICOLOGY. 20(3). p.607-624
abstract
Epigenetics is the study of mitotically or meiotically heritable changes in gene function that occur without a change in the DNA sequence. Interestingly, epigenetic changes can be triggered by environmental factors. Environmental exposure to e.g. metals, persistent organic pollutants or endocrine disrupting chemicals has been shown to modulate epigenetic marks, not only in mammalian cells or rodents, but also in environmentally relevant species such as fish or water fleas. The associated changes in gene expression often lead to modifications in the affected organism's phenotype. Epigenetic changes can in some cases be transferred to subsequent generations, even when these generations are no longer exposed to the external factor which induced the epigenetic change, as observed in a study with fungicide exposed rats. The possibility of this phenomenon in other species was demonstrated in water fleas exposed to the epigenetic drug 5-azacytidine. This way, populations can experience the effects of their ancestors' exposure to chemicals, which has implications for environmental risk assessment. More basic research is needed to assess the potential phenotypic and population-level effects of epigenetic modifications in different species and to evaluate the persistence of chemical exposure-induced epigenetic effects in multiple subsequent generations.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
TRANSGENERATIONAL INHERITANCE, HISTONE MODIFICATIONS, ENVIRONMENTAL EPIGENETICS, DNA methylation, GENE-EXPRESSION, DIETARY-PROTEIN RESTRICTION, DIETHYLSTILBESTROL EXPOSURE, METHYLTRANSFERASE ACTIVITY, ADULT-ONSET DISEASE, Transgenerational effects, Invertebrates, Environmental toxicology, ENDOCRINE DISRUPTOR VINCLOZOLIN, GENOMIC DNA METHYLATION
journal title
ECOTOXICOLOGY
Ecotoxicology
volume
20
issue
3
issue title
Special issue on evolutionary process in ecotoxicology
pages
607 - 624
Web of Science type
Article
Web of Science id
000289848600013
JCR category
ENVIRONMENTAL SCIENCES
JCR impact factor
2.355 (2011)
JCR rank
60/203 (2011)
JCR quartile
2 (2011)
ISSN
0963-9292
DOI
10.1007/s10646-011-0634-0
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1219637
handle
http://hdl.handle.net/1854/LU-1219637
date created
2011-05-09 10:57:22
date last changed
2011-05-09 11:13:22
@article{1219637,
  abstract     = {Epigenetics is the study of mitotically or meiotically heritable changes in gene function that occur without a change in the DNA sequence. Interestingly, epigenetic changes can be triggered by environmental factors. Environmental exposure to e.g. metals, persistent organic pollutants or endocrine disrupting chemicals has been shown to modulate epigenetic marks, not only in mammalian cells or rodents, but also in environmentally relevant species such as fish or water fleas. The associated changes in gene expression often lead to modifications in the affected organism's phenotype. Epigenetic changes can in some cases be transferred to subsequent generations, even when these generations are no longer exposed to the external factor which induced the epigenetic change, as observed in a study with fungicide exposed rats. The possibility of this phenomenon in other species was demonstrated in water fleas exposed to the epigenetic drug 5-azacytidine. This way, populations can experience the effects of their ancestors' exposure to chemicals, which has implications for environmental risk assessment. More basic research is needed to assess the potential phenotypic and population-level effects of epigenetic modifications in different species and to evaluate the persistence of chemical exposure-induced epigenetic effects in multiple subsequent generations.},
  author       = {Vandegehuchte, Michiel and Janssen, Colin},
  issn         = {0963-9292},
  journal      = {ECOTOXICOLOGY},
  keyword      = {TRANSGENERATIONAL INHERITANCE,HISTONE MODIFICATIONS,ENVIRONMENTAL EPIGENETICS,DNA methylation,GENE-EXPRESSION,DIETARY-PROTEIN RESTRICTION,DIETHYLSTILBESTROL EXPOSURE,METHYLTRANSFERASE ACTIVITY,ADULT-ONSET DISEASE,Transgenerational effects,Invertebrates,Environmental toxicology,ENDOCRINE DISRUPTOR VINCLOZOLIN,GENOMIC DNA METHYLATION},
  language     = {eng},
  number       = {3},
  pages        = {607--624},
  title        = {Epigenetics and its implications for ecotoxicology},
  url          = {http://dx.doi.org/10.1007/s10646-011-0634-0},
  volume       = {20},
  year         = {2011},
}

Chicago
Vandegehuchte, Michiel, and Colin Janssen. 2011. “Epigenetics and Its Implications for Ecotoxicology.” Ecotoxicology 20 (3): 607–624.
APA
Vandegehuchte, Michiel, & Janssen, C. (2011). Epigenetics and its implications for ecotoxicology. ECOTOXICOLOGY, 20(3), 607–624.
Vancouver
1.
Vandegehuchte M, Janssen C. Epigenetics and its implications for ecotoxicology. ECOTOXICOLOGY. 2011;20(3):607–24.
MLA
Vandegehuchte, Michiel, and Colin Janssen. “Epigenetics and Its Implications for Ecotoxicology.” ECOTOXICOLOGY 20.3 (2011): 607–624. Print.