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Tissue doppler imaging and two-dimensional speckle tracking detect left ventricular hypocontractility in horses exposed to ionophores

Annelies Decloedt (UGent) , Tinne Verheyen (UGent) and Gunther van Loon (UGent)
Author
Organization
Abstract
Introduction: Tissue Doppler imaging (TDI) and two-dimensional Speckle Tracking (2DST) are new echocardiographic techniques for quantifying left ventricular (LV) function. The aim of this study was to evaluate LV function by TDI and 2DST in horses following ionophore intoxication. Material and Methods: Repeated plasma cardiac troponin I (cTnI) measurements and echocardiographic examinations (Vivid 7 Pro, GE Healthcare) were performed on seven horses accidentally intoxicated with lasalocid. Images were recorded from right parasternal short-axis (TDI and 2DST) and long-axis (2DST) views. Peak radial myocardial strain (deformation) was measured by TDI in the interventricular septum (SRIVS) and LV free wall (SRLV). By 2DST, global radial (SR2DST), circumferential (SC2DST) and longitudinal (SL2DST) strain was measured. Fractional shortening (FS%) was calculated for comparison. Results: All horses showed elevated cTnI levels at admission (range 1.39–816 ng/mL) which decreased during follow-up. In total, 31 exams were performed between 1 and 370 days after admission. Five horses showed severely decreased SRIVS (4.93–25.41%), SRLV (5.81–16.88%), SR2DST (11.04–33.13%), SC2DST (-5.32–-15.29%), SL2DST (-9.15–-21.00%) and FS% (5–24%) at one or more occasions, indicating LV hypocontractility. During long-term follow-up, strain and FS% increased. In one horse, it took six to twelve months before measurements returned to reference values for SRIVS (49.58±6.34%), SRLV (74.63±16.09), SR2DST (63.64±3.13%), SC2DST (-19.65±1.87%), SL2DST (-24.80±2.36%) and FS% (37±3.9%). Overall, SR2DST, SC2DST, SL2DST and FS% showed significant correlations with cTnI (p<0.01). All TDI- and 2DST-measurements were correlated with FS% (p<0.001). Conclusion: TDI- and 2DST-measurements allowed accurate detection and quantification of LV dysfunction and correlated with cTnI and FS%.
Keywords
echocardiography, equine, cardiology, myocardial function

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MLA
Decloedt, Annelies, Tinne Verheyen, and Gunther van Loon. “Tissue Doppler Imaging and Two-dimensional Speckle Tracking Detect Left Ventricular Hypocontractility in Horses Exposed to Ionophores.” European Veterinary Conference : Voorjaarsdagen : Proceedings. 2011. 365–366. Print.
APA
Decloedt, Annelies, Verheyen, T., & van Loon, G. (2011). Tissue doppler imaging and two-dimensional speckle tracking detect left ventricular hypocontractility in horses exposed to ionophores. European Veterinary Conference : Voorjaarsdagen : proceedings (pp. 365–366). Presented at the 2011 European Veterinary Conference : Voorjaarsdagen.
Chicago author-date
Decloedt, Annelies, Tinne Verheyen, and Gunther van Loon. 2011. “Tissue Doppler Imaging and Two-dimensional Speckle Tracking Detect Left Ventricular Hypocontractility in Horses Exposed to Ionophores.” In European Veterinary Conference : Voorjaarsdagen : Proceedings, 365–366.
Chicago author-date (all authors)
Decloedt, Annelies, Tinne Verheyen, and Gunther van Loon. 2011. “Tissue Doppler Imaging and Two-dimensional Speckle Tracking Detect Left Ventricular Hypocontractility in Horses Exposed to Ionophores.” In European Veterinary Conference : Voorjaarsdagen : Proceedings, 365–366.
Vancouver
1.
Decloedt A, Verheyen T, van Loon G. Tissue doppler imaging and two-dimensional speckle tracking detect left ventricular hypocontractility in horses exposed to ionophores. European Veterinary Conference : Voorjaarsdagen : proceedings. 2011. p. 365–6.
IEEE
[1]
A. Decloedt, T. Verheyen, and G. van Loon, “Tissue doppler imaging and two-dimensional speckle tracking detect left ventricular hypocontractility in horses exposed to ionophores,” in European Veterinary Conference : Voorjaarsdagen : proceedings, Amsterdam, The Netherlands, 2011, pp. 365–366.
@inproceedings{1217277,
  abstract     = {Introduction: Tissue Doppler imaging (TDI) and two-dimensional Speckle Tracking (2DST) are new echocardiographic techniques for quantifying left ventricular (LV) function. The aim of this study was to evaluate LV function by TDI and 2DST in horses following ionophore intoxication. Material and Methods: Repeated plasma cardiac troponin I (cTnI) measurements and echocardiographic examinations (Vivid 7 Pro, GE Healthcare) were performed on seven horses  accidentally intoxicated with lasalocid. Images were recorded from right parasternal short-axis (TDI and 2DST) and long-axis (2DST) views. Peak radial myocardial strain (deformation) was measured by TDI in the interventricular septum (SRIVS) and LV free wall (SRLV). By 2DST, global radial (SR2DST), circumferential (SC2DST) and longitudinal (SL2DST) strain was measured. Fractional shortening (FS%) was calculated for comparison. Results: All horses showed elevated cTnI levels at admission (range 1.39–816 ng/mL) which decreased during follow-up. In total, 31 exams were performed between 1 and 370 days after admission. Five horses showed severely decreased SRIVS (4.93–25.41%), SRLV (5.81–16.88%), SR2DST (11.04–33.13%), SC2DST (-5.32–-15.29%), SL2DST (-9.15–-21.00%) and FS% (5–24%)  at one or more occasions, indicating LV hypocontractility. During long-term follow-up, strain and FS% increased. In one horse, it took six to twelve months before measurements returned to reference values for SRIVS (49.58±6.34%), SRLV (74.63±16.09), SR2DST (63.64±3.13%), SC2DST (-19.65±1.87%), SL2DST (-24.80±2.36%) and FS% (37±3.9%). Overall, SR2DST, SC2DST, SL2DST and FS% showed significant correlations with cTnI (p<0.01). All TDI- and 2DST-measurements were correlated with FS% (p<0.001). Conclusion: TDI- and 2DST-measurements allowed accurate detection and quantification of LV dysfunction and correlated with cTnI and FS%.},
  author       = {Decloedt, Annelies and Verheyen, Tinne and van Loon, Gunther},
  booktitle    = {European Veterinary Conference : Voorjaarsdagen : proceedings},
  isbn         = {9789081414852},
  keywords     = {echocardiography,equine,cardiology,myocardial function},
  language     = {eng},
  location     = {Amsterdam, The Netherlands},
  pages        = {365--366},
  title        = {Tissue doppler imaging and two-dimensional speckle tracking detect left ventricular hypocontractility in horses exposed to ionophores},
  year         = {2011},
}